BRCA2 Protein

"BRCA2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)

Descriptor ID	D024682
MeSH Number(s)	D12.776.313.249 D12.776.624.776.101 D12.776.660.105
Concept/Terms	BRCA2 Protein BRCA2 Protein FANCD1 Protein Fanconi Anemia Complementation Group D1 Protein Fanconi Anemia Group D1 Protein BRCA2 Gene Product Breast Cancer 2 Gene Product Fanconi Anemia Group D1 Complementing Protein Breast Cancer 2 Protein

Below are MeSH descriptors whose meaning is more general than "BRCA2 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Fanconi Anemia Complementation Group Proteins [D12.776.313]
BRCA2 Protein [D12.776.313.249]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
BRCA2 Protein [D12.776.624.776.101]
Nuclear Proteins [D12.776.660]
BRCA2 Protein [D12.776.660.105]

Below are MeSH descriptors whose meaning is related to "BRCA2 Protein".

Below are MeSH descriptors whose meaning is more specific than "BRCA2 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "BRCA2 Protein" by people in this website by year, and whether "BRCA2 Protein" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2012	0	1	1
2016	1	0	1
2018	0	2	2
2019	2	0	2
2020	2	1	3
2021	1	0	1
2022	2	0	2
2024	0	2	2
2025	1	0	1
2026	0	1	1

Below are the most recent publications written about "BRCA2 Protein" by people in Profiles.

Balkwill FR, Laumont CM, Burdett N, Le Saux O, Garsed DW, Grither WR, Nijhuis AM, Recouvreux MS, Kang Z, Zhang R, Chiappinelli KB, Lee JS, Laniti DD, McNeish I, Ahmed AA, Rottapel R, Conejo-Garcia JR, Odunsi K, Pharoah PDP, Zamarin D, Ishak CA, Fotopoulou C, Buckanovich RJ, Labidi-Galy I, Brenton JD, Lengyel E, Cook DP, George SHL, Lheureux S, Drapkin R, Nephew KP, Adams S, Pathania S, Nelson BH, F?rkkil? A, Fuh K, Neel BG, Bowtell DD. Rethinking ovarian cancer III: the past decade and future directions. Nat Rev Cancer. 2026 Jun; 26(6):452-471.

View in: PubMed
Situ K, Duan H, Godin SK, Yang J, McCloskey GQ, Naeem B, Gillis MK, Zeb MH, Salhotra S, Rawal P, Patel N, Mouliere SK, Chen J, B?k?si A, P?link?s HL, Venkatesan S, Green AM, Birkbak NJ, V?rtessy BG, Swanton C, Pathania S. BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability. Nat Commun. 2025 Oct 29; 16(1):9544.

View in: PubMed
MacGilvary N, Cantor SB. Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer. DNA Repair (Amst). 2024 12; 144:103775.

View in: PubMed
Polan RM, Ali-Fehmi R, Grace AK, Mattei LH, Tanner EJ, Morris RT. Occult residual ovarian tissue at the time of minimally invasive risk reducing surgery in women with BRCA mutations. Gynecol Oncol. 2024 10; 189:37-40.

View in: PubMed
Bhardwaj PV, Abdou YG. Germline Genetic Testing in Breast Cancer: Systemic Therapy Implications. Curr Oncol Rep. 2022 12; 24(12):1791-1800.

View in: PubMed
Cong K, Cantor SB. Exploiting replication gaps for cancer therapy. Mol Cell. 2022 07 07; 82(13):2363-2369.

View in: PubMed
Cantor SB. Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer". DNA Repair (Amst). 2021 Nov; 107:103209.

View in: PubMed
Cimadamore A, Cheng L, Massari F, Santoni M, Pepi L, Franzese C, Scarpelli M, Lopez-Beltran A, Galosi AB, Montironi R. Circulating Tumor DNA Testing for Homology Recombination Repair Genes in Prostate Cancer: From the Lab to the Clinic. Int J Mol Sci. 2021 May 24; 22(11).

View in: PubMed
Haddad JM, Robison K, Beffa L, Laprise J, ScaliaWilbur J, Raker CA, Clark MA, Hofstatter E, Dalela D, Brown A, Bradford L, Toland M, Stuckey A. Family planning in carriers of BRCA1 and BRCA2 pathogenic variants. J Genet Couns. 2021 12; 30(6):1570-1581.

View in: PubMed
Panzarino NJ, Krais JJ, Cong K, Peng M, Mosqueda M, Nayak SU, Bond SM, Calvo JA, Doshi MB, Bere M, Ou J, Deng B, Zhu LJ, Johnson N, Cantor SB. Replication Gaps Underlie BRCA Deficiency and Therapy Response. Cancer Res. 2021 03 01; 81(5):1388-1397.

View in: PubMed

People

Explore

Similar Concepts

Top Journals