Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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Oikemus S, Hu K, Shin M, Idrizi F, Goodman-Khan A, Kolb A, Ghanta KS, Lee J, Wagh A, Wolfe SA, Zhu LJ, Watts JK, Lawson ND. Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome. Development. 2025 Jun 15; 152(12).
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Hanlon MB, Shohet JM, Wolfe SA. Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death. Nat Commun. 2025 Jun 02; 16(1):5126.
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Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, Langenbucher A, Monroe S, Su W, Cabanos HF, Siddiqui FM, Phan N, Jalili P, Timonina D, Bilton S, Gomez-Caraballo M, Archibald HL, Nangia V, Dionne K, Riley A, Lawlor M, Banwait MK, Cobb RG, Zou L, Dyson NJ, Ott CJ, Benes C, Getz G, Chan CS, Shaw AT, Gainor JF, Lin JJ, Sequist LV, Piotrowska Z, Yeap BY, Engelman JA, Lee JJ, Maruvka YE, Buisson R, Lawrence MS, Hata AN. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. 2023 08; 620(7973):393-401.
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Min J, Zhao J, Zagelbaum J, Lee J, Takahashi S, Cummings P, Schooley A, Dekker J, Gottesman ME, Rabadan R, Gautier J. Mechanisms of insertions at a DNA double-strand break. Mol Cell. 2023 07 20; 83(14):2434-2448.e7.
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Zheng C, Liu B, Dong X, Gaston N, Sontheimer EJ, Xue W. Template-jumping prime editing enables large insertion and exon rewriting in vivo. Nat Commun. 2023 06 08; 14(1):3369.
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Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA. Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Nat Methods. 2023 Jun; 20(6):898-907.
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Cong K, Cantor SB. Exploiting replication gaps for cancer therapy. Mol Cell. 2022 07 07; 82(13):2363-2369.
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Cantor SB. Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer". DNA Repair (Amst). 2021 Nov; 107:103209.
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Majhi PD, Griner NB, Mayfield JA, Compton S, Kane JJ, Baptiste TA, Dunphy KA, Roberts AL, Schneider SS, Savage EM, Patel D, Blackburn AC, Maurus KJ, Wiesm?ller L, Jerry DJ. Genetic modifiers regulating DNA replication and double-strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni syndrome. Oncogene. 2021 08; 40(31):5026-5037.
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Panzarino NJ, Krais JJ, Cong K, Peng M, Mosqueda M, Nayak SU, Bond SM, Calvo JA, Doshi MB, Bere M, Ou J, Deng B, Zhu LJ, Johnson N, Cantor SB. Replication Gaps Underlie BRCA Deficiency and Therapy Response. Cancer Res. 2021 03 01; 81(5):1388-1397.