Antineoplastic Agents, Alkylating

"Antineoplastic Agents, Alkylating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Descriptor ID	D018906
MeSH Number(s)	D27.505.519.124.035 D27.505.954.248.150 D27.888.569.035.035
Concept/Terms	Antineoplastic Agents, Alkylating Antineoplastic Agents, Alkylating Alkylating Antineoplastic Agents Alkylating Antineoplastic Drugs Alkylating Antineoplastics Antineoplastic Alkylating Agents Antineoplastic Drugs, Alkylating Antineoplastics, Alkylating Alkylating Agents, Antineoplastic Alkylating Drugs, Antineoplastic Antineoplastic Alkylating Drugs Drugs, Antineoplastic Alkylating

Below are MeSH descriptors whose meaning is more general than "Antineoplastic Agents, Alkylating".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Alkylating Agents [D27.505.519.124]
Antineoplastic Agents, Alkylating [D27.505.519.124.035]
Therapeutic Uses [D27.505.954]
Antineoplastic Agents [D27.505.954.248]
Antineoplastic Agents, Alkylating [D27.505.954.248.150]
Toxic Actions [D27.888]
Noxae [D27.888.569]
Alkylating Agents [D27.888.569.035]
Antineoplastic Agents, Alkylating [D27.888.569.035.035]

Below are MeSH descriptors whose meaning is related to "Antineoplastic Agents, Alkylating".

Below are MeSH descriptors whose meaning is more specific than "Antineoplastic Agents, Alkylating".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antineoplastic Agents, Alkylating" by people in this website by year, and whether "Antineoplastic Agents, Alkylating" was a major or minor topic of these publications.

Bar chart showing 25 publications over 14 distinct years, with a maximum of 3 publications in 2014 and 2015 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2000	0	1	1
2002	1	0	1
2003	1	0	1
2004	1	0	1
2006	1	1	2
2010	1	1	2
2012	1	1	2
2014	1	2	3
2015	2	1	3
2016	2	1	3
2017	0	1	1
2018	2	0	2
2020	0	2	2

Below are the most recent publications written about "Antineoplastic Agents, Alkylating" by people in Profiles.

Das A, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Preconditioning with INC280 and LDK378 drugs sensitizes MGMT-unmethylated glioblastoma to temozolomide: Pre-clinical assessment. J Neurol Sci. 2020 Nov 15; 418:117102.

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Wolf GT, Liu S, Bellile E, Sartor M, Rozek L, Thomas D, Nguyen A, Zarins K, McHugh JB. Tumor infiltrating lymphocytes after neoadjuvant IRX-2 immunotherapy in oral squamous cell carcinoma: Interim findings from the INSPIRE trial. Oral Oncol. 2020 12; 111:104928.

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Ward SM, Skinner M, Saha B, Emrick T. Polymer-Temozolomide Conjugates as Therapeutics for Treating Glioblastoma. Mol Pharm. 2018 11 05; 15(11):5263-5276.

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Ali AN, Zhang P, Yung WKA, Chen Y, Movsas B, Urtasun RC, Jones CU, Choi KN, Michalski JM, Fischbach AJ, Markoe AM, Schultz CJ, Penas-Prado M, Garg MK, Hartford AC, Kim HE, Won M, Curran WJ. NRG oncology RTOG 9006: a phase III randomized trial of hyperfractionated radiotherapy (RT) and BCNU versus standard RT and BCNU for malignant glioma patients. J Neurooncol. 2018 Mar; 137(1):39-47.

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Cai YS, Sarotti AM, G?ndisch D, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorg Med Chem Lett. 2017 10 15; 27(20):4630-4634.

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Voorhees PM, Usmani SZ. The role of high-dose melphalan and autologous stem cell transplant in the rapidly evolving era of modern multiple myeloma therapy. Clin Adv Hematol Oncol. 2016 Sep; 14(9):719-28.

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Kamiya-Matsuoka C, Cachia D, Waguespack SG, Crane CH, Mahajan A, Brown PD, Nam JY, McCutcheon IE, Penas-Prado M. Radiotherapy with concurrent temozolomide for the management of extraneural metastases in pituitary carcinoma. Pituitary. 2016 Aug; 19(4):415-21.

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Strickland BA, Cachia D, Jalali A, Cykowski MD, Penas-Prado M, Langford LA, Li J, Shah K, Weinberg JS. Spinal Anaplastic Oligodendroglioma With Oligodendrogliomatosis: Molecular Markers and Management: Case Report. Neurosurgery. 2016 Mar; 78(3):E466-73.

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D'Souza A, Dispenzieri A, Wirk B, Zhang MJ, Huang J, Gertz MA, Kyle RA, Kumar S, Comenzo RL, Peter Gale R, Lazarus HM, Savani BN, Cornell RF, Weiss BM, Vogl DT, Freytes CO, Scott EC, Landau HJ, Moreb JS, Costa LJ, Ramanathan M, Callander NS, Kamble RT, Olsson RF, Ganguly S, Nishihori T, Kindwall-Keller TL, Wood WA, Mark TM, Hari P. Improved Outcomes After Autologous Hematopoietic Cell Transplantation for Light Chain Amyloidosis: A Center for International Blood and Marrow Transplant Research Study. J Clin Oncol. 2015 Nov 10; 33(32):3741-9.

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Kim J, Lee IH, Cho HJ, Park CK, Jung YS, Kim Y, Nam SH, Kim BS, Johnson MD, Kong DS, Seol HJ, Lee JI, Joo KM, Yoon Y, Park WY, Lee J, Park PJ, Nam DH. Spatiotemporal Evolution of the Primary Glioblastoma Genome. Cancer Cell. 2015 Sep 14; 28(3):318-28.

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