Header Logo

Guodong Tie PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentSurgery
AddressUmass Chan Medical School
55 Lake Ave N
Worcester MA 01655-0002
Phone508-856-1015
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentSurgery


    Collapse Biography 
    Collapse education and training
    Gansu Agricultural University, Gansu, , ChinaPHDReproductive Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suzuki M, Hasegawa Y, Zhang H, Liang Z, Tie G, Shivdasani RA, Waldor MK. IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice. Nat Microbiol. 2026 Jul; 11(7):1949-1966. PMID: 42236988.
      Citations:    
    2. Suzuki M, Hasegawa Y, Zhang H, Liang Z, Tie G, Shivdasani RA, Waldor MK. IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice. bioRxiv. 2026 May 28. PMID: 41959413.
      Citations:    
    3. Bhattacharya S, Tie G, Singh PNP, Malagola E, Eskiocak O, He R, Kraiczy J, Gu W, Perlov Y, Alici-Garipcan A, Beyaz S, Wang TC, Zhou Q, Shivdasani RA. Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell. Cell Stem Cell. 2025 Jun 05; 32(6):952-969.e8. PMID: 40203837.
      Citations:    
    4. Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, Bhattacharya S, Hoshino M, de Sauvage FJ, Murata K, Jadhav U, Shivdasani RA. Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 04; 640(8057):231-239. PMID: 39778708.
      Citations:    
    5. Imada S, Khawaled S, Shin H, Meckelmann SW, Whittaker CA, Corr?a RO, Alquati C, Lu Y, Tie G, Pradhan D, Calibasi-Kocal G, Nascentes Melo LM, Allies G, R?sler J, Wittenhofer P, Krystkiewicz J, Schmitz OJ, Roper J, Vinolo MAR, Ricciardiello L, Lien EC, Vander Heiden MG, Shivdasani RA, Cheng CW, Tasdogan A, Yilmaz ?H. Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature. 2024 09; 633(8031):895-904. PMID: 39169180.
      Citations:    
    6. Yan J, Tie G, Tutto A, Messina LM. Hypercholesterolemia impairs collateral artery enlargement by ten-eleven translocation 1-dependent hematopoietic stem cell autonomous mechanism in a murine model of limb ischemia. JVS Vasc Sci. 2024; 5:100203. PMID: 38774713.
      Citations:    
    7. Manieri E, Tie G, Malagola E, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, Wang TC, He R, McCarthy N, Shivdasani RA. Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche. Nat Commun. 2023 12 02; 14(1):7978. PMID: 38042929.
      Citations:    
    8. Kraiczy J, McCarthy N, Malagola E, Tie G, Madha S, Boffelli D, Wagner DE, Wang TC, Shivdasani RA. Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 04 06; 30(4):433-449.e8. PMID: 37028407.
      Citations:    
    9. McCarthy N, Tie G, Madha S, He R, Kraiczy J, Maglieri A, Shivdasani RA. Smooth muscle contributes to the development and function of a layered intestinal stem cell niche. Dev Cell. 2023 04 10; 58(7):550-564.e6. PMID: 36924771.
      Citations:    
    10. Manieri E, Tie G, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, He R, McCarthy N, Shivdasani RA. Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023 Feb 24. PMID: 36798304.
      Citations:    
    11. Tie G, Yan J, Khair L, Tutto A, Messina LM. Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway. Sci Rep. 2020 02 27; 10(1):3567. PMID: 32107419.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    12. Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, Fazzio TG, Messina LM. Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages. Nat Commun. 2018 01 02; 9(1):33. PMID: 29295997.
      Citations: 80     Fields:    Translation:AnimalsCells
    13. Tie G. Invited commentary. J Vasc Surg. 2017 12; 66(6):1863. PMID: 29169541.
      Citations:    Fields:    
    14. Tie G, Yan J, Khair L, Messina JA, Deng A, Kang J, Fazzio T, Messina LM. Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and ?d T Cells from Hematopoietic Stem Cells. Cancer Res. 2017 05 01; 77(9):2351-2362. PMID: 28249902.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    15. Tie G, Yan J, Messina JA, Raffai RL, Messina LM. Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells. J Vasc Res. 2015; 52(6):361-71. PMID: 27031525.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Tie G, Messina KE, Yan J, Messina JA, Messina LM. Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. J Am Heart Assoc. 2014 Jan 27; 3(1):e000241. PMID: 24470519.
      Citations: 30     Fields:    Translation:AnimalsCells
    17. Yan J, Tie G, Xu TY, Cecchini K, Messina LM. Mesenchymal stem cells as a treatment for peripheral arterial disease: current status and potential impact of type II diabetes on their therapeutic efficacy. Stem Cell Rev Rep. 2013 Jun; 9(3):360-72. PMID: 23475434.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    18. Yan J, Tie G, Wang S, Messina KE, DiDato S, Guo S, Messina LM. Type 2 diabetes restricts multipotency of mesenchymal stem cells and impairs their capacity to augment postischemic neovascularization in db/db mice. J Am Heart Assoc. 2012 Dec; 1(6):e002238. PMID: 23316315.
      Citations: 48     Fields:    Translation:AnimalsCells
    19. Yan J, Tie G, Messina LM. Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat. Mol Med. 2012 Oct 24; 18:1221-30. PMID: 23212846.
      Citations: 6     Fields:    Translation:AnimalsCells
    20. Yan J, Tie G, Messina LM. Tetrahydrobiopterin, L-arginine and vitamin C actsynergistically to decrease oxidative stress, increase nitricoxide and improve blood flow after induction of hindlimbischemia in the rat. Mol Med. 2012 May 09; 18:676-84. PMID: 22371305.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Yan J, Tie G, Hoffman A, Yang Y, Nowicki PT, Messina LM. Oral tetrahydrobiopterin improves the beneficial effect of adenoviral-mediated eNOS gene transfer after induction of hindlimb ischemia. Mol Ther. 2010 Aug; 18(8):1482-9. PMID: 20551918.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Tie G, Yan J, Yang Y, Park BD, Messina JA, Raffai RL, Nowicki PT, Messina LM. Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. J Vasc Res. 2010; 47(6):519-30. PMID: 20431300.
      Citations: 24     Fields:    Translation:AnimalsCells
    23. Park B, Hoffman A, Yang Y, Yan J, Tie G, Bagshahi H, Nowicki PT, Messina LM. Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice. J Vasc Surg. 2010 Jan; 51(1):165-73. PMID: 19879098.
      Citations: 23     Fields:    Translation:AnimalsCells
    24. Yan J, Tie G, Park B, Yan Y, Nowicki PT, Messina LM. Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: roles of endothelial nitric oxide synthase and endothelial progenitor cells. J Vasc Surg. 2009 Dec; 50(6):1412-22. PMID: 19837544.
      Citations: 58     Fields:    Translation:AnimalsCells
    25. Yang Y, Tang G, Yan J, Park B, Hoffman A, Tie G, Wang R, Messina LM. Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse. J Vasc Surg. 2008 Dec; 48(6):1546-58. PMID: 19118738.
      Citations: 32     Fields:    Translation:Animals
    Tie's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (173)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _