Discs Large Homolog 1 Protein
"Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.
| Descriptor ID |
D000074288
|
| MeSH Number(s) |
D08.811.913.696.650.450.500 D12.644.360.024.287 D12.776.157.057.023 D12.776.476.024.325 D12.776.543.213
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Discs Large Homolog 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Discs Large Homolog 1 Protein".
This graph shows the total number of publications written about "Discs Large Homolog 1 Protein" by people in this website by year, and whether "Discs Large Homolog 1 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles.
-
Frese KK, Latorre IJ, Chung SH, Caruana G, Bernstein A, Jones SN, Donehower LA, Justice MJ, Garner CC, Javier RT. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006 Mar 22; 25(6):1406-17.
-
Nakagawa T, Futai K, Lashuel HA, Lo I, Okamoto K, Walz T, Hayashi Y, Sheng M. Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron. 2004 Oct 28; 44(3):453-67.
-
Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron. 1996 Jul; 17(1):103-13.
-
Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature. 1995 Nov 02; 378(6552):85-8.