Oligonucleotides

"Oligonucleotides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Descriptor ID	D009841
MeSH Number(s)	D13.695.578.424
Concept/Terms	Oligonucleotides Oligonucleotides

Below are MeSH descriptors whose meaning is more general than "Oligonucleotides".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Polynucleotides [D13.695.578]
Oligonucleotides [D13.695.578.424]

Below are MeSH descriptors whose meaning is related to "Oligonucleotides".

Below are MeSH descriptors whose meaning is more specific than "Oligonucleotides".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Oligonucleotides" by people in this website by year, and whether "Oligonucleotides" was a major or minor topic of these publications.

Bar chart showing 157 publications over 30 distinct years, with a maximum of 15 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	0	1	1
1997	1	0	1
1998	5	0	5
1999	3	2	5
2000	0	1	1
2001	1	0	1
2002	4	6	10
2003	9	1	10
2004	8	6	14
2005	6	9	15
2006	7	2	9
2007	5	3	8
2008	3	4	7
2009	1	2	3
2010	4	2	6
2011	5	1	6
2012	1	3	4
2013	4	3	7
2014	2	2	4
2015	3	1	4
2016	1	1	2
2017	3	1	4
2018	2	1	3
2019	3	1	4
2020	3	1	4
2021	5	1	6
2022	2	2	4
2023	0	4	4
2024	0	4	4

Below are the most recent publications written about "Oligonucleotides" by people in Profiles.

Matesanz SE, Brigatti KW, Young M, Yum SW, Strauss KA. Preemptive dual therapy for children at risk for infantile-onset spinal muscular atrophy. Ann Clin Transl Neurol. 2024 Jul; 11(7):1868-1878.

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Agrawal S. Considerations for Creating the Next Generation of RNA Therapeutics: Oligonucleotide Chemistry and Innate Immune Responses to Nucleic Acids. Nucleic Acid Ther. 2024 04; 34(2):37-51.

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Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Res. 2024 Jan 25; 52(2):977-997.

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Sharma VK, Mangla P, Singh SK, Prasad AK. Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic Biology Applications. Curr Org Synth. 2024; 21(4):436-455.

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Shah S, Sharp KJ, Raju Ponny S, Lee J, Watts JK, Berry-Kravis E, Richter JD. Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP. Proc Natl Acad Sci U S A. 2023 07 04; 120(27):e2302534120.

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Hildebrand SR, Hedger AK, Yamada K, Watts JK, Khvorova A. Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors. RNA. 2023 07; 29(7):1077-1083.

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Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 03 14; 120(11):e2219523120.

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Shahbazi R, Lipson P, Gottimukkala KSV, Lane DD, Adair JE. CRISPR Gene Editing of Hematopoietic Stem and Progenitor Cells. Methods Mol Biol. 2023; 2567:39-62.

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Goyenvalle A, Jimenez-Mallebrera C, van Roon W, Sewing S, Krieg AM, Arechavala-Gomeza V, Andersson P. Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides. Nucleic Acid Ther. 2023 01; 33(1):1-16.

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Maiti A, Hedger AK, Myint W, Balachandran V, Watts JK, Schiffer CA, Matsuo H. Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state. Nat Commun. 2022 11 19; 13(1):7117.

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