Phosphorothioate Oligonucleotides
"Phosphorothioate Oligonucleotides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.
| Descriptor ID |
D054735
|
| MeSH Number(s) |
D13.695.578.424.575
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Phosphorothioate Oligonucleotides".
Below are MeSH descriptors whose meaning is more specific than "Phosphorothioate Oligonucleotides".
This graph shows the total number of publications written about "Phosphorothioate Oligonucleotides" by people in this website by year, and whether "Phosphorothioate Oligonucleotides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphorothioate Oligonucleotides" by people in Profiles.
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Moazami MP, Rembetsy-Brown JM, Sarli SL, McEachern HR, Wang F, Ohara M, Wagh A, Kelly K, Krishnamurthy PM, Weiss A, Marosfoi M, King RM, Motwani M, Gray-Edwards H, Fitzgerald KA, Brown RH, Watts JK. Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system. Mol Ther. 2024 Dec 04; 32(12):4401-4417.
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Shin M, Meda Krishnamurthy P, Devi G, Watts JK. Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction. Nucleic Acid Ther. 2022 02; 32(1):66-73.
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Biscans A, Caiazzi J, Davis S, McHugh N, Sousa J, Khvorova A. The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy. Nucleic Acids Res. 2020 08 20; 48(14):7665-7680.
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Jurk M, Chikh G, Schulte B, Kritzler A, Richardt-Pargmann D, Lampron C, Luu R, Krieg AM, Vicari AP, Vollmer J. Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif. Nucleic Acid Ther. 2011 Jun; 21(3):201-14.
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Ashman RF, Goeken JA, Latz E, Lenert P. Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding. Int Immunol. 2011 Mar; 23(3):203-14.
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Leamon CP, Cooper SR, Hardee GE. Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo. Bioconjug Chem. 2003 Jul-Aug; 14(4):738-47.