CRISPR-Cas Systems

"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.

Descriptor ID	D064113
MeSH Number(s)	G05.308.203.374.394
Concept/Terms	CRISPR-Cas Systems CRISPR-Cas Systems CRISPR Cas Systems CRISPR-Cas System System, CRISPR-Cas Systems, CRISPR-Cas

Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
CRISPR-Cas Systems [G05.308.203.374.394]

Below are MeSH descriptors whose meaning is related to "CRISPR-Cas Systems".

Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.

Bar chart showing 215 publications over 13 distinct years, with a maximum of 32 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	6	1	7
2015	8	3	11
2016	11	11	22
2017	16	6	22
2018	14	10	24
2019	13	19	32
2020	8	6	14
2021	8	14	22
2022	3	9	12
2023	9	7	16
2024	4	7	11
2025	3	15	18
2026	2	2	4

Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.

Nelson C, Ambros V. Multi-dimensional regulation of LIN-28 temporal expression dynamics in the C. elegans heterochronic gene cascade. Development. 2026 05 15; 153(10).

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Iyer S, Daman K, Sun Y, Tutto A, Holbrook SE, Joynt AT, Yan J, Ambegaokar P, Guo D, Liu P, Stauffer JE, Maitland SA, Lee SM, Xiao Y, Huang HC, Zhu LJ, Gallagher TL, Cox GA, Keeler AM, Siegwart DJ, Emerson CP, Wolfe SA. SORT LNPs encapsulating Cas9 mRNA achieve efficient editing in skeletal muscle in a dystrophic mouse model. Mol Ther. 2026 Jul 01; 34(7):3885-3902.

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Castelli JMP, Poljakov K, Jwa Y, Cunningham R, Cassidy ME, Gray MD, Sanchez Gaytan JN, Enstrom MR, Gastelum G, Wang Z, Linton JD, Rongvaux A, Taylor JJ, Adair JE. In vivo production of an anti-HIV antibody in mice by non-viral gene knockin in primate hematopoietic stem and progenitor cells. Mol Ther. 2026 May 06; 34(5):2754-2769.

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Gottimukkala KSV, Lane DD, Cunningham R, Malik HS, Jwa Y, Cassidy ME, Castelli JMP, Enstrom MR, Poljakov K, Gastelum G, Ho SH, Tassa C, Adair JE. CRISPR-AuNP: physicochemical optimization of a gold nanoparticle platform for cost-effective and modular non-viral gene editing in HSPCs. Gene Ther. 2026 03; 33(2):188-202.

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Calhoun CCS, Capps MES, Muya K, Gannaway WC, Martina V, Conklin CL, Klein MC, Webster JM, Torija-Olson EG, Thyme SB. Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function. Elife. 2025 Nov 18; 13.

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Luo D, Wang N, Major-Monfried H, Ralls J, Rha S, Maitland SA, Ponnienselvan K, Yamada M, Bauer DE, Wolfe SA, Kentsis A. Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates. Bioconjug Chem. 2025 11 19; 36(11):2472-2486.

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Serreze DV, Tousey-Pfarrer M, Racine JJ. Humanized Mouse Models for Type 1 Diabetes. Curr Protoc. 2025 Oct; 5(10):e70224.

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Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Roh K, Lawton J, Kim N, Silverstein RA, Ferreira da Silva J, de la Cruz D, Richa R, Xie J, Gray-Edwards HL, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice. Nat Biomed Eng. 2026 May; 10(5):952-967.

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Zhou C, Jiang F, Chen W, Nugen SR, Huang C. Synthetic biology meets diagnostics: Engineering biosensing platforms for rapid and accurate pathogen and viral detection. Biosens Bioelectron. 2025 Dec 15; 290:117946.

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Gao J, Bamidele N, Pires-Ferreira D, Zheng C, Destefano A, Cheng H, Tang Q, Cao Y, Xie J, Gao G, Gruntman A, Sontheimer E, Flotte TR, Xue W. A compact base editor rescues AATD-associated liver and lung disease in mouse models. Mol Ther. 2025 11 05; 33(11):5817-5828.

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