CRISPR-Cas Systems

"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.

Descriptor ID	D064113
MeSH Number(s)	G05.308.203.374.394
Concept/Terms	CRISPR-Cas Systems CRISPR-Cas Systems CRISPR Cas Systems CRISPR-Cas System System, CRISPR-Cas Systems, CRISPR-Cas

Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
CRISPR-Cas Systems [G05.308.203.374.394]

Below are MeSH descriptors whose meaning is related to "CRISPR-Cas Systems".

Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.

Bar chart showing 211 publications over 12 distinct years, with a maximum of 32 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	6	1	7
2015	8	3	11
2016	11	12	23
2017	16	6	22
2018	14	9	23
2019	13	19	32
2020	8	6	14
2021	8	14	22
2022	3	8	11
2023	9	7	16
2024	4	7	11
2025	4	15	19

Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.

Calhoun CCS, Capps MES, Muya K, Gannaway WC, Martina V, Conklin CL, Klein MC, Webster JM, Torija-Olson EG, Thyme SB. Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function. Elife. 2025 Nov 18; 13.

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Luo D, Wang N, Major-Monfried H, Ralls J, Rha S, Maitland SA, Ponnienselvan K, Yamada M, Bauer DE, Wolfe SA, Kentsis A. Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates. Bioconjug Chem. 2025 Nov 19; 36(11):2472-2486.

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Serreze DV, Tousey-Pfarrer M, Racine JJ. Humanized Mouse Models for Type 1 Diabetes. Curr Protoc. 2025 Oct; 5(10):e70224.

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Zhou C, Jiang F, Chen W, Nugen SR, Huang C. Synthetic biology meets diagnostics: Engineering biosensing platforms for rapid and accurate pathogen and viral detection. Biosens Bioelectron. 2025 Dec 15; 290:117946.

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Bamidele N, Pires-Ferreira D, Zheng C, Destefano A, Cheng H, Tang Q, Cao Y, Xie J, Gao G, Gruntman A, Sontheimer E, Flotte TR, Xue W. A compact base editor rescues AATD-associated liver and lung disease in mouse models. Mol Ther. 2025 Nov 05; 33(11):5817-5828.

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Lou S, DJiake Tihagam R, Wasko UN, Equbal Z, Venkatesan S, Braczyk K, Przanowski P, Il Koo B, Saltani I, Singh AT, Likhite S, Powers S, Souza GMPR, Maxwell RA, Yu J, Zhu LJ, Beenhakker M, Abbott SBG, Lu Z, Green MR, Meyer KC, Tushir-Singh J, Bhatnagar S. Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype. Nat Commun. 2025 Jul 04; 16(1):6169.

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Oikemus S, Hu K, Shin M, Idrizi F, Goodman-Khan A, Kolb A, Ghanta KS, Lee J, Wagh A, Wolfe SA, Zhu LJ, Watts JK, Lawson ND. Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome. Development. 2025 Jun 15; 152(12).

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Hanlon MB, Shohet JM, Wolfe SA. Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death. Nat Commun. 2025 Jun 02; 16(1):5126.

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Anderson RK, Nugen SR. Genetic engineering of bacteriophage S16 for Salmonella separation, concentration, and detection. Anal Bioanal Chem. 2025 Jul; 417(18):4069-4081.

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Bourgade B, Xie H, Lindblad P, Stensj? K. Development of a CRISPR activation system for targeted gene upregulation in Synechocystis sp. PCC 6803. Commun Biol. 2025 May 21; 8(1):772.

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