Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 1252 publications over 31 distinct years, with a maximum of 79 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	8	8
1996	0	6	6
1997	0	11	11
1998	0	13	13
1999	0	14	14
2000	0	21	21
2001	0	33	33
2002	1	44	45
2003	0	42	42
2004	2	45	47
2005	1	48	49
2006	1	52	53
2007	0	58	58
2008	0	68	68
2009	0	69	69
2010	0	58	58
2011	1	59	60
2012	2	77	79
2013	0	64	64
2014	1	67	68
2015	1	67	68
2016	1	44	45
2017	0	49	49
2018	0	54	54
2019	1	46	47
2020	0	37	37
2021	1	37	38
2022	0	12	12
2023	0	10	10
2024	3	13	16
2025	0	10	10

Below are the most recent publications written about "Protein Binding" by people in Profiles.

?rd M, Winters MJ, Subbanna MS, de Mart?n Garrido N, Cushing VI, Kliche J, Benz C, Ivarsson Y, Greber BJ, Pryciak PM, Davey NE. High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants. Nat Commun. 2025 Aug 15; 16(1):7622.

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Geng Q, McClements DJ, Dai T, Zhou W, Wu Z, Chen H. Exploration of Non-Covalent Interactions of Peanut Allergen Ara h 2 With Tannic Acid: Insights Into Molecular Structure and In Vitro Allergenicity. J Food Sci. 2025 Aug; 90(8):e70432.

View in: PubMed
Agrawal A, Ngwa DN, Simons JP, Singh SK. Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface. Front Immunol. 2025; 16:1631409.

View in: PubMed
Rudolph MJ, Muriuki BM, Chen Y, Vance DJ, Vorauer C, Piazza CL, Freeman-Gallant G, Golonka RM, Mirabile G, Guttman M, Cavacini LA, Mantis NJ. Germline encoded residues dominate the interaction of a human monoclonal antibody with decorin binding protein A of Borrelia burgdorferi. Front Immunol. 2025; 16:1611828.

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Du Y, Yang Y, Nguyen SN, Kaltashov IA. The Role of Long-Range Non-Specific Electrostatic Interactions in Inhibiting the Pre-Fusion Proteolytic Processing of the SARS-CoV-2 S Glycoprotein by Heparin. Biomolecules. 2025 May 28; 15(6).

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Marang CP, Petersen DJ, Scott BD, Walcott S, Debold EP. Characterizing the concentration and load dependence of phosphate binding to rabbit fast skeletal actomyosin. Proc Natl Acad Sci U S A. 2025 May 20; 122(20):e2504758122.

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Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2426427122.

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Liu Z, Tan Y, Flynn WF, Sun L, Pratumkaew P, Alcoforado Diniz J, Oliveira NAJ, McDonough JA, Skarnes WC, Robson P. HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs. Cell Rep. 2025 Apr 22; 44(4):115568.

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Rish AD, Fosuah E, Shen Z, Marathe IA, Wysocki VH, Fu TM. Architecture remodeling activates the HerA-DUF anti-phage defense system. Mol Cell. 2025 Mar 20; 85(6):1189-1201.e5.

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Subbanna MS, Winters MJ, ?rd M, Davey NE, Pryciak PM. A quantitative intracellular peptide-binding assay reveals recognition determinants and context dependence of short linear motifs. J Biol Chem. 2025 Mar; 301(3):108225.

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