Proteolysis

"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.

Descriptor ID	D059748
MeSH Number(s)	G02.111.720 G03.812
Concept/Terms	Proteolysis Proteolysis Proteolyses Protein Degradation Degradation, Protein Degradations, Protein Protein Degradations Protein Digestion Protein Digestion Digestion, Protein Digestions, Protein Protein Digestions

Below are MeSH descriptors whose meaning is more general than "Proteolysis".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Proteolysis [G02.111.720]
Metabolism [G03]
Proteolysis [G03.812]

Below are MeSH descriptors whose meaning is related to "Proteolysis".

Below are MeSH descriptors whose meaning is more specific than "Proteolysis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.

Bar chart showing 128 publications over 15 distinct years, with a maximum of 15 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	3	0	3
2012	0	7	7
2013	4	10	14
2014	1	11	12
2015	4	11	15
2016	2	3	5
2017	5	9	14
2018	5	9	14
2019	3	8	11
2020	2	8	10
2021	2	4	6
2022	2	3	5
2023	0	3	3
2024	3	2	5
2025	1	3	4

Below are the most recent publications written about "Proteolysis" by people in Profiles.

Skorupka KA, Matsuoka K, Hassan B, Ghirlando R, Balachandran V, Chen TH, Walters KJ, Schiffer CA, Wolf M, Iwatani Y, Matsuo H. HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation. Nat Commun. 2025 Jul 01; 16(1):5879.

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Yigit K, Chien P. Lon-dependent proteolysis in oxidative stress responses. J Bacteriol. 2025 Jul 24; 207(7):e0000525.

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Du Y, Yang Y, Nguyen SN, Kaltashov IA. The Role of Long-Range Non-Specific Electrostatic Interactions in Inhibiting the Pre-Fusion Proteolytic Processing of the SARS-CoV-2 S Glycoprotein by Heparin. Biomolecules. 2025 May 28; 15(6).

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Hong L, Ye T, Wang TZ, Srijay D, Liu H, Zhao L, Watson R, Vincoff S, Chen T, Kholina K, Goel S, DeLisa MP, Chatterjee P. Programmable protein stabilization with language model-derived peptide guides. Nat Commun. 2025 Apr 15; 16(1):3555.

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Sin YY, Giblin A, Judina A, Rujirachaivej P, Corral LG, Glennon E, Tai ZX, Feng T, Torres E, Zorn A, Gorelik J, Kyurkchieva E, Yenchitsomanus PT, Swindlehurst C, Chan K, Stirling D, Baillie GS. Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS J. 2025 Jul; 292(13):3360-3377.

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Flynn JM, Joyce ME, Bolon DNA. Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation. Mol Biol Cell. 2025 Jan 01; 36(1):ar5.

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Yerramilli VS, Lin G, Reisinger JL, Hemmerlin RM, Lindberg SK, Plante K, Ross AH, Gericke A, Scarlata S. The scaffolding protein IQGAP1 enhances EGFR signaling by promoting oligomerization and preventing degradation. J Biol Chem. 2024 11; 300(11):107844.

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Jo M, Lee JS, Tocheny CE, Lero MW, Bui QT, Morgan JS, Shaw LM. Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function. J Biol Chem. 2024 11; 300(11):107796.

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Yigit K, Chien P. Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus. J Bacteriol. 2024 07 25; 206(7):e0023724.

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Chitre M, Emery P. ATXN2 is a target of N-terminal proteolysis. PLoS One. 2023; 18(12):e0296085.

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