Proteolysis

"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.

Descriptor ID	D059748
MeSH Number(s)	G02.111.720 G03.812
Concept/Terms	Proteolysis Proteolysis Proteolyses Protein Degradation Degradation, Protein Degradations, Protein Protein Degradations Protein Digestion Protein Digestion Digestion, Protein Digestions, Protein Protein Digestions

Below are MeSH descriptors whose meaning is more general than "Proteolysis".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Proteolysis [G02.111.720]
Metabolism [G03]
Proteolysis [G03.812]

Below are MeSH descriptors whose meaning is related to "Proteolysis".

Below are MeSH descriptors whose meaning is more specific than "Proteolysis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.

Bar chart showing 121 publications over 14 distinct years, with a maximum of 15 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	3	0	3
2012	0	7	7
2013	4	10	14
2014	1	11	12
2015	4	11	15
2016	2	3	5
2017	5	9	14
2018	5	9	14
2019	2	7	9
2020	2	8	10
2021	2	4	6
2022	2	3	5
2023	0	3	3
2024	2	2	4

Below are the most recent publications written about "Proteolysis" by people in Profiles.

Flynn JM, Joyce ME, Bolon DNA. Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation. Mol Biol Cell. 2025 Jan 01; 36(1):ar5.

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Yerramilli VS, Lin G, Reisinger JL, Hemmerlin RM, Lindberg SK, Plante K, Ross AH, Gericke A, Scarlata S. The scaffolding protein IQGAP1 enhances EGFR signaling by promoting oligomerization and preventing degradation. J Biol Chem. 2024 Nov; 300(11):107844.

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Jo M, Lee JS, Tocheny CE, Lero MW, Bui QT, Morgan JS, Shaw LM. Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function. J Biol Chem. 2024 Nov; 300(11):107796.

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Yigit K, Chien P. Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus. J Bacteriol. 2024 07 25; 206(7):e0023724.

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Chitre M, Emery P. ATXN2 is a target of N-terminal proteolysis. PLoS One. 2023; 18(12):e0296085.

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Nandadasa S, Martin D, Deshpande G, Robert KL, Stack MS, Itoh Y, Apte SS. Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate. Mol Cell Proteomics. 2023 Jun; 22(6):100566.

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Funsten MC, Yurkovetskiy LA, Kuznetsov A, Reiman D, Hansen CHF, Senter KI, Lee J, Ratiu J, Dahal-Koirala S, Antonopoulos DA, Dunny GM, Sollid LM, Serreze D, Khan AA, Chervonsky AV. Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes. Cell Host Microbe. 2023 02 08; 31(2):213-227.e9.

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Yarikipati P, Bergmann A. In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening. J Vis Exp. 2022 10 06; (188).

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Bondeson DP, Mullin-Bernstein Z, Oliver S, Skipper TA, Atack TC, Bick N, Ching M, Guirguis AA, Kwon J, Langan C, Millson D, Paolella BR, Tran K, Wie SJ, Vazquez F, Tothova Z, Golub TR, Sellers WR, Ianari A. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022 09 20; 13(1):5495.

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Olney SG, Chien P, Kearns DB. SmiA is a hybrid priming/scaffolding adaptor for the LonA protease in Bacillus subtilis. J Biol Chem. 2022 07; 298(7):102045.

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