Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 280 publications over 31 distinct years, with a maximum of 21 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	7	7
1996	0	6	6
1997	0	1	1
1998	0	3	3
1999	0	4	4
2000	0	6	6
2001	0	5	5
2002	0	21	21
2003	0	11	11
2004	0	9	9
2005	0	9	9
2006	0	13	13
2007	0	16	16
2008	0	9	9
2009	0	13	13
2010	1	13	14
2011	0	13	13
2012	0	14	14
2013	0	10	10
2014	1	9	10
2015	0	12	12
2016	0	16	16
2017	0	9	9
2018	0	10	10
2019	0	9	9
2020	0	7	7
2021	0	8	8
2022	0	3	3
2023	0	3	3
2024	0	8	8
2025	0	1	1

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Banas V, Elfawal MA, Rosa BA, Mahoney M, Kauffman J, Goetz E, Chen P, Aroian RV, Mitreva M, Janetka JW. Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections. ACS Infect Dis. 2025 Feb 14; 11(2):506-517.

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Bisht P, Bhattacharya A, Pal A, Singh R, Verma SK. Design and synthesis of novel 3,7-dihydro-1H-purine-2,6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach. Eur J Med Chem. 2025 Feb 05; 283:117160.

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Zhao X, Di J, Luo D, Verma R, Verma SK, Verma S, Ravindar L, Koshle A, Dewangan HK, Gupta R, Chandra S, Deshpande S, Vaishnav Y, Rakesh KP. Thiazole - A promising scaffold for antituberculosis agents and structure-activity relationships studies. Bioorg Chem. 2025 Jan; 154:108035.

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Zhang X, Liu Z, Ma X, Zheng Y, Hu H, Jiao B, McClements DJ, Wang Q, Shi A. Interfacial and foaming properties of plant and microbial proteins: Comparison of structure-function behavior of different proteins. Food Chem. 2025 Jan 15; 463(Pt 4):141431.

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Qiu Z, Xiang L, Han Y, Zhang B, Qiao X, Zheng Z, Xiao H. Structure-anti-inflammatory activity relationship of garlic fructans in mice with dextran sulfate sodium-induced colitis: Impact of chain length. Carbohydr Polym. 2024 Dec 15; 346:122582.

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Karadkhelkar NM, Gupta P, Barasa L, Chilamakuri R, Hlordzi CK, Acharekar N, Agarwal S, Chen ZS, Yoganathan S. Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents. ChemMedChem. 2024 Jul 02; 19(13):e202300715.

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Zaino AM, Dash RC, James SJ, MacGilvary N, Crompton A, McPherson KS, Stanzione M, Korzhnev DM, Dyson NJ, Chatterjee N, Cantor SB, Hadden MK. Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction. Bioorg Med Chem. 2024 May 15; 106:117755.

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Verma SK, Rangappa S, Verma R, Xue F, Verma S, Sharath Kumar KS, Rangappa KS. Sulfur (S?)-containing heterocyclic hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and its SAR. Bioorg Chem. 2024 04; 145:107241.

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Kohal R, Bisht P, Gupta GD, Verma SK. Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations. Bioorg Chem. 2024 02; 143:107095.

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Kou F, Mei Y, Wang W, Wei X, Xiao H, Wu X. Phellinus linteus polysaccharides: A review on their preparation, structure-activity relationships, and drug delivery systems. Int J Biol Macromol. 2024 Feb; 258(Pt 1):128702.

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