Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 284 publications over 31 distinct years, with a maximum of 20 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	6	6
1997	0	1	1
1998	0	3	3
1999	0	5	5
2000	0	7	7
2001	0	4	4
2002	0	20	20
2003	0	11	11
2004	0	9	9
2005	0	8	8
2006	0	14	14
2007	0	16	16
2008	0	9	9
2009	0	13	13
2010	1	13	14
2011	0	13	13
2012	0	16	16
2013	0	10	10
2014	1	10	11
2015	0	12	12
2016	0	17	17
2017	0	9	9
2018	0	10	10
2019	0	10	10
2020	0	7	7
2021	0	8	8
2022	0	3	3
2023	0	3	3
2024	0	5	5
2025	0	7	7
2026	0	3	3

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Holdaway JA, Saini L, Coil-Otto R, Nayyab S, Taghavi M, Visconti P, Georg GI. Development of TSSK1 and TSSK2 Targeted Degraders Reveals Sperm Machinery for Protein Degradation and Potential for Nonhormonal Male Contraception. J Med Chem. 2026 Jun 25; 69(12):14236-14254.

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Zhang Y, Wu C, Li Y, Zhao P, Dai R, McClements DJ, Liu F. Structure-function insights into heat/pH-shift-treated legume protein-EGCG conjugates as functional alternative proteins for stabilizing walnut oil emulsions. Int J Biol Macromol. 2026 Apr; 359:151637.

View in: PubMed
Barasa L, DeOrsey L, O'Reilly MD, Choudhary S, Cahill SE, Mathur A, Allabaji A, Nellikkalaya S, Paul S, Vidadala SR, Sarkar SK, Rajendran M, Patil SN, Kalonia H, Hale J, Humphries F, Fitzgerald KA, Thompson PR. Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pathway. J Med Chem. 2026 Apr 09; 69(7):8561-8582.

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Kaur J, Spielvogel E, Nageswara Rao D, Rusere LN, Shaqra AM, Lockbaum GJ, Maryam A, Yilmaz NK, Swanstrom R, Schiffer CA, Ali A. Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur J Med Chem. 2026 Feb 15; 304:118510.

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D'Almeida RE, Chen P, Huang Y, Goetz E, Sammeta VR, Yang B, Rao RP, Rasapalli S, Elfawal MA. Design, synthesis, and biological evaluation of a focused pyrrolo- and pyrido-quinazolinone natural products-templated library for anti-fungal and anthelmintic activities. Bioorg Med Chem. 2026 Mar; 134:118517.

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Singh A, Barasa L, DeOrsey L, O'Reilly MD, Choudhary S, Cahill SE, Rossetti T, Green RM, Humphries F, Thompson PR. Triazole-based STING inhibitors. Bioorg Med Chem. 2026 Jan 01; 132:118484.

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Elfawal MA, Banas V, Rosa BA, Mahoney M, Goetz E, Chen P, Aroian RV, Janetka JW, Mitreva M. Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections. ACS Infect Dis. 2025 Nov 14; 11(11):3196-3211.

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Liu J, Du H, Song Y, Wang J, Tian W, Zhong R, Cao Y, Xiao H, Wang Q. Systematic review of hypoglycemic polysaccharides: sources, preparation, and identification techniques, evaluation models, structure-activity relationships, and mechanistic insights. Crit Rev Food Sci Nutr. 2025; 65(33):8624-8662.

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Sharma S, Raju S, Verma SK, Verma R, Thakur PK, Sharath Kumar KS. Pyrazoles: A Master Key to Tackle Multidrug-Resistant Acinetobacter baumannii and Its Structure Activity Relationship Studies. Chem Biol Drug Des. 2025 Mar; 105(3):e70092.

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Lv S, Zhu Z, Xiao H. Flavonoids and their metal complexes as potential agents for diabetes mellitus with future perspectives. Crit Rev Food Sci Nutr. 2025; 65(30):7170-7200.

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