Wnt Signaling Pathway

"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.

Descriptor ID	D060449
MeSH Number(s)	G02.111.820.925 G04.835.925
Concept/Terms	Wnt Signaling Pathway Wnt Signaling Pathway Pathway, Wnt Signaling Pathways, Wnt Signaling Signaling Pathway, Wnt Signaling Pathways, Wnt Wnt Signaling Pathways Wnt Pathway Pathway, Wnt Pathways, Wnt Wnt Pathways Wnt beta-Catenin Signaling Pathway Wnt beta-Catenin Signaling Pathway Wnt beta Catenin Signaling Pathway Wnt Pathway, Canonical Canonical Wnt Pathway Canonical Wnt Pathways Pathway, Canonical Wnt Pathways, Canonical Wnt Wnt Pathways, Canonical

Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Wnt Signaling Pathway [G02.111.820.925]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Wnt Signaling Pathway [G04.835.925]

Below are MeSH descriptors whose meaning is related to "Wnt Signaling Pathway".

Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in this website by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.

Bar chart showing 50 publications over 13 distinct years, with a maximum of 9 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	0	1
2012	3	2	5
2013	4	5	9
2014	0	3	3
2015	4	2	6
2016	1	2	3
2017	3	2	5
2018	2	1	3
2019	3	1	4
2020	1	4	5
2021	1	1	2
2023	1	1	2
2024	0	2	2

Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles.

Lin C, Yang YS, Ma H, Chen Z, Chen D, John AA, Xie J, Gao G, Shim JH. Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss. Mol Ther. 2024 Sep 04; 32(9):3080-3100.

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Gregory KJ, Mason H, Casaubon J, Schneider SS. SFRP1 decreases WNT-Mediated M2 macrophage marker expression in breast tissue. Cancer Immunol Immunother. 2024 Mar 30; 73(5):86.

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Yang Loureiro Z, Joyce S, DeSouza T, Solivan-Rivera J, Desai A, Skritakis P, Yang Q, Ziegler R, Zhong D, Nguyen TT, MacDougald OA, Corvera S. Wnt signaling preserves progenitor cell multipotency during adipose tissue development. Nat Metab. 2023 06; 5(6):1014-1028.

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Chaudagar K, Hieromnimon HM, Khurana R, Labadie B, Hirz T, Mei S, Hasan R, Shafran J, Kelley A, Apostolov E, Al-Eryani G, Harvey K, Rameshbabu S, Loyd M, Bynoe K, Drovetsky C, Solanki A, Markiewicz E, Zamora M, Fan X, Sch?rer S, Swarbrick A, Sykes DB, Patnaik A. Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer. Clin Cancer Res. 2023 05 15; 29(10):1952-1968.

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Chaugule S, Kim JM, Yang YS, Knobeloch KP, He X, Shim JH. Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling. Int J Mol Sci. 2021 Sep 24; 22(19).

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Sandiford OA, Donnelly RJ, El-Far MH, Burgmeyer LM, Sinha G, Pamarthi SH, Sherman LS, Ferrer AI, DeVore DE, Patel SA, Naaldijk Y, Alonso S, Barak P, Bryan M, Ponzio NM, Narayanan R, Etchegaray JP, Kumar R, Rameshwar P. Mesenchymal Stem Cell-Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region. Cancer Res. 2021 03 15; 81(6):1567-1582.

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Comiskey DF, He H, Liyanarachchi S, Sheikh MS, Hendrickson IV, Yu L, Brock PL, de la Chapelle A. Characterizing the function of EPB41L4A in the predisposition to papillary thyroid carcinoma. Sci Rep. 2020 11 17; 10(1):19984.

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Yazici Y, McAlindon TE, Gibofsky A, Lane NE, Clauw D, Jones M, Bergfeld J, Swearingen CJ, DiFrancesco A, Simsek I, Tambiah J, Hochberg MC. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial. Arthritis Rheumatol. 2020 10; 72(10):1694-1706.

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Pandey A, Stawiski EW, Durinck S, Gowda H, Goldstein LD, Barbhuiya MA, Schr?der MS, Sreenivasamurthy SK, Kim SW, Phalke S, Suryamohan K, Lee K, Chakraborty P, Kode V, Shi X, Chatterjee A, Datta K, Khan AA, Subbannayya T, Wang J, Chaudhuri S, Gupta S, Shrivastav BR, Jaiswal BS, Poojary SS, Bhunia S, Garcia P, Bizama C, Rosa L, Kwon W, Kim H, Han Y, Yadav TD, Ramprasad VL, Chaudhuri A, Modrusan Z, Roa JC, Tiwari PK, Jang JY, Seshagiri S. Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. Nat Commun. 2020 08 24; 11(1):4225.

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Leibold J, Ruscetti M, Cao Z, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, S?nchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW. Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Cancer Discov. 2020 07; 10(7):1038-1057.

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