Cellular Senescence

"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.

Descriptor ID	D016922
MeSH Number(s)	G04.043
Concept/Terms	Cellular Senescence Cellular Senescence Senescence, Cellular Cell Senescence Senescence, Cell Cell Aging Cell Aging Cellular Ageing Ageing, Cellular Aging, Cell Senescence, Replicative Cellular Aging Aging, Cellular Replicative Senescence Cell Ageing Ageing, Cell Senescence-Associated Secretory Phenotype Senescence-Associated Secretory Phenotype Phenotype, Senescence-Associated Secretory Secretory Phenotype, Senescence-Associated Senescence Associated Secretory Phenotype

Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cellular Senescence [G04.043]

Below are MeSH descriptors whose meaning is related to "Cellular Senescence".

Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.

Bar chart showing 95 publications over 29 distinct years, with a maximum of 8 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	1	1	2
2000	0	1	1
2001	0	1	1
2002	2	1	3
2003	0	2	2
2004	2	2	4
2005	3	0	3
2006	1	0	1
2007	3	4	7
2008	4	0	4
2009	3	2	5
2010	1	1	2
2011	4	3	7
2012	1	1	2
2013	2	6	8
2014	2	2	4
2015	3	0	3
2016	6	1	7
2017	0	2	2
2018	3	3	6
2019	1	2	3
2020	0	1	1
2021	0	1	1
2022	1	0	1
2023	0	3	3
2024	4	1	5
2025	3	1	4
2026	1	1	2

Below are the most recent publications written about "Cellular Senescence" by people in Profiles.

Cui W, Xiao H, Wen X, Li C, Bao S, Zeng J, Li Y, Qiao Y, Wang K, Wang H, Huang J, Guo Q. Identifying a cancer therapeutic target: Cell-SELEX identifies a membrane protein for aptamer-mediated growth suppression. Proc Natl Acad Sci U S A. 2026 Mar 31; 123(13):e2514681123.

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Zhou L, DeMarco KD, Murphy KC, Wu Z, Li J, Johnson C, Liu B, Giwa HK, Ma B, Bhalerao N, Li J, Jiang Z, Bai S, Parikh CN, Ye T, Simin K, Zhu LJ, Pitarresi JR, Wu H, Ruscetti M. p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression and Progression That Can Be Reversed by Senolytic Therapy. Cancer Discov. 2026 Mar 02; 16(3):571-591.

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Abdulkhaliq AA, Alasiri G, Khan J, Ajoolabady A, Tuomilehto J, Henninger N, Bahijri S, Pratico D, Borai A, Alrfaei BM, Kim B, Ren J. SIRT1 in Aging and Diseases. J Cell Biochem. 2025 10; 126(10):e70069.

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Zhang F, Wang Y, Zhang L, Wang C, Chen D, Liu H, Xu R, Haynes CM, Shim JH, Ge X. The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence. Elife. 2025 Jul 07; 13.

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Gross PS, Dur?n-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.

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Ruscetti M. Lineage tracing senescence in?vivo shows not all senescent cells are created equal. Dev Cell. 2025 01 06; 60(1):3-4.

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Zhou L, Ma B, Ruscetti M. Cellular senescence offers distinct immunological vulnerabilities in cancer. Trends Cancer. 2025 Apr; 11(4):334-350.

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Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nat Aging. 2025 Jan; 5(1):21-27.

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Karabag D, Heneka MT, Ising C. The putative contribution of cellular senescence to driving tauopathies. Trends Immunol. 2024 10; 45(10):837-848.

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Chibaya L, DeMarco KD, Lusi CF, Kane GI, Brassil ML, Parikh CN, Murphy KC, Chowdhury SR, Li J, Ma B, Naylor TE, Cerrutti J, Mori H, Diaz-Infante M, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Sci Transl Med. 2024 08 28; 16(762):eadj9366.

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