Cellular Senescence

"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.

Descriptor ID	D016922
MeSH Number(s)	G04.043
Concept/Terms	Cellular Senescence Cellular Senescence Senescence, Cellular Cell Senescence Senescence, Cell Cell Aging Cell Aging Cellular Ageing Ageing, Cellular Aging, Cell Senescence, Replicative Cellular Aging Aging, Cellular Replicative Senescence Cell Ageing Ageing, Cell Senescence-Associated Secretory Phenotype Senescence-Associated Secretory Phenotype Phenotype, Senescence-Associated Secretory Secretory Phenotype, Senescence-Associated Senescence Associated Secretory Phenotype

Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cellular Senescence [G04.043]

Below are MeSH descriptors whose meaning is related to "Cellular Senescence".

Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.

Bar chart showing 89 publications over 28 distinct years, with a maximum of 7 publications in 2007 and 2011 and 2013 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	1	1
1999	1	1	2
2000	0	1	1
2001	0	1	1
2002	2	1	3
2003	0	1	1
2004	2	2	4
2005	2	0	2
2006	1	0	1
2007	3	4	7
2008	4	0	4
2009	3	2	5
2010	1	1	2
2011	4	3	7
2012	2	1	3
2013	1	6	7
2014	3	2	5
2015	3	0	3
2016	6	1	7
2017	0	2	2
2018	2	3	5
2019	1	2	3
2021	0	1	1
2022	1	0	1
2023	0	2	2
2024	5	1	6
2025	2	0	2

Below are the most recent publications written about "Cellular Senescence" by people in Profiles.

Gross PS, Dur?n-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.

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Ruscetti M. Lineage tracing senescence in?vivo shows not all senescent cells are created equal. Dev Cell. 2025 01 06; 60(1):3-4.

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Zhou L, Ma B, Ruscetti M. Cellular senescence offers distinct immunological vulnerabilities in cancer. Trends Cancer. 2025 Apr; 11(4):334-350.

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Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nat Aging. 2025 Jan; 5(1):21-27.

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Karabag D, Heneka MT, Ising C. The putative contribution of cellular senescence to driving tauopathies. Trends Immunol. 2024 Oct; 45(10):837-848.

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Chibaya L, DeMarco KD, Lusi CF, Kane GI, Brassil ML, Parikh CN, Murphy KC, Chowdhury SR, Li J, Ma B, Naylor TE, Cerrutti J, Mori H, Diaz-Infante M, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Sci Transl Med. 2024 Aug 28; 16(762):eadj9366.

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Chowdhury SR, Murphy KC, Parikh CN, DeMarco KD, Zhou L, Ruscetti M. Measuring the impact of therapy-induced senescence on NK cell phenotypes in cancer. Methods Cell Biol. 2024; 190:171-201.

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Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, Mordechai-Heyn T, Pitarresi JR, Atias D, Steinberg E, Bidany-Mizrahi T, Forkosh E, Katz LH, Benny O, Golan T, Hofree M, Stewart SA, Atlan KA, Zamir G, Stanger BZ, Berger M, Ben-Porath I. Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice. Nat Commun. 2024 Jul 22; 15(1):6162.

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Karabag D, Scheiblich H, Griep A, Santarelli F, Schwartz S, Heneka MT, Ising C. Characterizing microglial senescence: Tau as a key player. J Neurochem. 2023 08; 166(3):517-533.

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Zhou L, Ruscetti M. Senescent macrophages: A new "old" player in lung cancer development. Cancer Cell. 2023 07 10; 41(7):1201-1203.

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