rho-Associated Kinases

"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Descriptor ID	D054460
MeSH Number(s)	D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
Concept/Terms	rho-Associated Kinases rho-Associated Kinases rho Associated Kinases rho-Associated Kinase rho Associated Kinase ROCK Protein Kinases Protein Kinases, ROCK rho-Associated Coiled-Coil Kinase Coiled-Coil Kinase, rho-Associated rho Associated Coiled Coil Kinase rho-Kinase rho Kinase ROK Kinase rho-Associated Kinase 1 rho-Associated Kinase 1 rho Associated Kinase 1 ROCK-I Protein Kinase ROCK I Protein Kinase p160ROCK rho-Associated Kinase beta rho Associated Kinase beta rho-Associated Protein Kinase beta rho Associated Protein Kinase beta rho-Associated Coiled-Coil Containing Protein Kinase 1 rho Associated Coiled Coil Containing Protein Kinase 1 rho-Associated Kinase 2 rho-Associated Kinase 2 rho Associated Kinase 2 rho-Associated Kinase alpha rho Associated Kinase alpha rho-Associated Coiled-Coil Containing Protein Kinase 2 rho Associated Coiled Coil Containing Protein Kinase 2 ROCK-II Protein Kinase ROCK II Protein Kinase p160 rhoA-Binding Kinase ROKalpha p160 rhoA Binding Kinase ROKalpha rho-Associated Protein Kinase alpha rho Associated Protein Kinase alpha

Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
rho-Associated Kinases [D08.811.913.696.620.682.700.814]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
rho-Associated Kinases [D12.644.360.590]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
rho-Associated Kinases [D12.776.476.595]

Below are MeSH descriptors whose meaning is related to "rho-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2005 and 2009 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	2	2
2007	1	0	1
2008	1	0	1
2009	2	0	2
2010	0	1	1
2013	0	2	2
2014	1	0	1
2018	0	1	1
2019	1	0	1
2020	0	1	1
2024	0	1	1
2025	1	0	1

Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.

Fang M, Banday S, Deibler SK, Simone TM, Coleman M, O'Connor E, Li R, Zhu LJ, Green MR. Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia. J Neurosci. 2025 Jun 25; 45(26).

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Pittala S, Haspula D, Cui Y, Yang WM, Kim YB, Davis RJ, Wing A, Rotman Y, McGuinness OP, Inoue A, Wess J. G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis. Nat Commun. 2024 11 19; 15(1):9996.

View in: PubMed
Posner DC, Lin H, Meigs JB, Kolaczyk ED, Dupuis J. Convex combination sequence kernel association test for rare-variant studies. Genet Epidemiol. 2020 06; 44(4):352-367.

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O'Connor E, Cairns G, Spendiff S, Burns D, Hettwer S, M?der A, M?ller J, Horvath R, Slater C, Roos A, Lochm?ller H. Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish. Cells. 2019 08 07; 8(8).

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Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, ?stevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018 08 30; 9(1):3524.

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Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK. Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01; 113(11):1307-1317.

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Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41.

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Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41.

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Palomino Doza J, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Bu'Lock FA, O'Sullivan J, Stuart AG, Parsons J, Relton C, Goodship J, Henderson DJ, Keavney B. Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot. BMC Genet. 2013 Jun 19; 14:57.

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Phillips HM, Mahendran P, Singh E, Anderson RH, Chaudhry B, Henderson DJ. Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets. Cardiovasc Res. 2013 Aug 01; 99(3):452-60.

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