Syk Kinase

"Syk Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.

Descriptor ID	D000072377
MeSH Number(s)	D08.811.913.696.620.682.725.650 D12.644.360.900 D12.776.476.913
Concept/Terms	Syk Kinase Syk Kinase Kinase, Syk SYK Tyrosine Kinase Kinase, SYK Tyrosine Tyrosine Kinase, SYK Spleen Tyrosine Kinase Kinase, Spleen Tyrosine Tyrosine Kinase, Spleen

Below are MeSH descriptors whose meaning is more general than "Syk Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Syk Kinase [D08.811.913.696.620.682.725.650]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Syk Kinase [D12.644.360.900]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Syk Kinase [D12.776.476.913]

Below are MeSH descriptors whose meaning is related to "Syk Kinase".

Below are MeSH descriptors whose meaning is more specific than "Syk Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Syk Kinase" by people in this website by year, and whether "Syk Kinase" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 3 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2013	0	2	2
2014	0	1	1
2016	2	1	3
2020	1	0	1
2022	0	1	1

Below are the most recent publications written about "Syk Kinase" by people in Profiles.

Schafer DP, Stillman JM. Microglia are SYK of A? and cell debris. Cell. 2022 10 27; 185(22):4043-4045.

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Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MK. Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. mBio. 2020 05 12; 11(3).

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Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, W?lchli S, Green MR, Tr?en G, Liest?l K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R. Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood. 2017 02 09; 129(6):759-770.

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Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 10 01; 197(7):2948-57.

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Bukong TN, Iracheta-Vellve A, Saha B, Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Catalano D, Kodys K, Szabo G. Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease. Hepatology. 2016 10; 64(4):1057-71.

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Bukong TN, Iracheta-Vellve A, Gyongyosi B, Ambade A, Catalano D, Kodys K, Szabo G. Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice. Alcohol Clin Exp Res. 2016 07; 40(7):1524-30.

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Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM. Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing ?-1,3 Glucan. J Immunol. 2016 Mar 01; 196(5):2249-61.

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Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014 Dec 01; 210(11):1844-54.

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Bukong TN, Kodys K, Szabo G. Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection. Hepatology. 2013 Nov; 58(5):1569-79.

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Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM. Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes. J Biol Chem. 2013 May 31; 288(22):16043-54.

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