Protein-Tyrosine Kinases

"Protein-Tyrosine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.

Descriptor ID	D011505
MeSH Number(s)	D08.811.913.696.620.682.725
Concept/Terms	Protein-Tyrosine Kinases Protein-Tyrosine Kinases Kinases, Protein-Tyrosine Protein Tyrosine Kinases Tyrosine Kinase Kinase, Tyrosine Tyrosine Protein Kinase Kinase, Tyrosine Protein Tyrosylprotein Kinase Kinase, Tyrosylprotein Tyrosine-Specific Protein Kinase Kinase, Tyrosine-Specific Protein Protein Kinase, Tyrosine-Specific Tyrosine Specific Protein Kinase Tyrosine-Specific Protein Kinases Kinases, Tyrosine-Specific Protein Protein Kinases, Tyrosine-Specific Tyrosine Specific Protein Kinases Protein-Tyrosine Kinase Kinase, Protein-Tyrosine Protein Tyrosine Kinase Tyrosine Protein Kinases Kinases, Tyrosine Protein Protein Kinases, Tyrosine

Below are MeSH descriptors whose meaning is more general than "Protein-Tyrosine Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]

Below are MeSH descriptors whose meaning is related to "Protein-Tyrosine Kinases".

Below are MeSH descriptors whose meaning is more specific than "Protein-Tyrosine Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein-Tyrosine Kinases" by people in this website by year, and whether "Protein-Tyrosine Kinases" was a major or minor topic of these publications.

Bar chart showing 96 publications over 24 distinct years, with a maximum of 12 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	2	0	2
1997	1	2	3
1998	3	2	5
1999	1	1	2
2000	1	1	2
2001	3	3	6
2002	8	4	12
2003	4	2	6
2004	3	0	3
2005	3	5	8
2006	5	1	6
2007	3	5	8
2009	2	1	3
2010	2	1	3
2011	2	2	4
2013	3	1	4
2014	2	0	2
2015	3	1	4
2016	2	1	3
2017	2	1	3
2019	1	0	1
2020	1	2	3
2021	2	0	2
2025	1	0	1

Below are the most recent publications written about "Protein-Tyrosine Kinases" by people in Profiles.

Simhal AK, Firestone RS, Oh JH, Avutu V, Norton L, Hultcrantz M, Usmani SZ, Maclachlan KH, Deasy JO. High WEE1 expression is independently linked to poor survival in multiple myeloma. Blood Cancer J. 2025 Feb 20; 15(1):22.

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Tahtouh T, Durieu E, Villiers B, Bruy?re C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, S?v?re E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, Burgy G, Guiheneuf S, Herault Y, Kendall DA, Carreaux F, Bazureau JP, Meijer L. Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. J Med Chem. 2022 01 27; 65(2):1396-1417.

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Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ. Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK. Proc Natl Acad Sci U S A. 2021 08 31; 118(35).

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Lechner K, Mott S, Al-Saifi R, Knipfer L, Wirtz S, Atreya R, Vieth M, Rath T, Fraass T, Winter Z, August A, Luban J, Zimmermann VS, Weigmann B, Neurath MF. Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis. Gastroenterology. 2021 10; 161(4):1270-1287.e19.

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Yazici Y, McAlindon TE, Gibofsky A, Lane NE, Clauw D, Jones M, Bergfeld J, Swearingen CJ, DiFrancesco A, Simsek I, Tambiah J, Hochberg MC. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial. Arthritis Rheumatol. 2020 10; 72(10):1694-1706.

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Conley JM, Gallagher MP, Rao A, Berg LJ. Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength. J Immunol. 2020 07 15; 205(2):335-345.

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Leech CM, Flynn MJ, Arsenault HE, Ou J, Liu H, Zhu LJ, Benanti JA. The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network. PLoS Genet. 2020 04; 16(4):e1008600.

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Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ. CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. Immunohorizons. 2020 02 07; 4(2):57-71.

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Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood. 2019 11 28; 134(22):1960-1972.

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Cho HS, Reboldi A, Hall JA, Berg LJ. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019 02 15; 10(1):784.

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