Cyclins

"Cyclins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.

Descriptor ID	D016213
MeSH Number(s)	D12.644.360.262 D12.776.167.218 D12.776.476.262
Concept/Terms	Cyclins Cyclins Cyclin

Below are MeSH descriptors whose meaning is more general than "Cyclins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclins [D12.644.360.262]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclins [D12.776.167.218]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclins [D12.776.476.262]

Below are MeSH descriptors whose meaning is related to "Cyclins".

Below are MeSH descriptors whose meaning is more specific than "Cyclins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclins" by people in this website by year, and whether "Cyclins" was a major or minor topic of these publications.

Bar chart showing 35 publications over 19 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	2	1	3
1996	1	0	1
1997	2	1	3
1998	2	0	2
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	1	2	3
2003	0	3	3
2004	1	1	2
2006	0	1	1
2007	0	4	4
2008	1	1	2
2012	1	1	2
2014	1	1	2
2015	1	0	1
2016	1	0	1
2018	0	1	1
2020	1	0	1

Below are the most recent publications written about "Cyclins" by people in Profiles.

Bandyopadhyay S, Bhaduri S, ?rd M, Davey NE, Loog M, Pryciak PM. Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In?Vivo. Curr Biol. 2020 11 16; 30(22):4454-4466.e5.

View in: PubMed
Repetto MV, Winters MJ, Bush A, Reiter W, Hollenstein DM, Ammerer G, Pryciak PM, Colman-Lerner A. CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. Mol Cell. 2018 03 15; 69(6):938-952.e6.

View in: PubMed
Williams KL, Topp S, Yang S, Smith B, Fifita JA, Warraich ST, Zhang KY, Farrawell N, Vance C, Hu X, Chesi A, Leblond CS, Lee A, Rayner SL, Sundaramoorthy V, Dobson-Stone C, Molloy MP, van Blitterswijk M, Dickson DW, Petersen RC, Graff-Radford NR, Boeve BF, Murray ME, Pottier C, Don E, Winnick C, McCann EP, Hogan A, Daoud H, Levert A, Dion PA, Mitsui J, Ishiura H, Takahashi Y, Goto J, Kost J, Gellera C, Gkazi AS, Miller J, Stockton J, Brooks WS, Boundy K, Polak M, Mu?oz-Blanco JL, Esteban-P?rez J, R?bano A, Hardiman O, Morrison KE, Ticozzi N, Silani V, de Belleroche J, Glass JD, Kwok JB, Guillemin GJ, Chung RS, Tsuji S, Brown RH, Garc?a-Redondo A, Rademakers R, Landers JE, Gitler AD, Rouleau GA, Cole NJ, Yerbury JJ, Atkin JD, Shaw CE, Nicholson GA, Blair IP. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nat Commun. 2016 Apr 15; 7:11253.

View in: PubMed
Bhaduri S, Valk E, Winters MJ, Gruessner B, Loog M, Pryciak PM. A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry. Curr Biol. 2015 Feb 02; 25(3):316-325.

View in: PubMed
Pope PA, Bhaduri S, Pryciak PM. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. Curr Biol. 2014 Jun 16; 24(12):1390-1396.

View in: PubMed
Ishidate T, Elewa A, Kim S, Mello CC, Shirayama M. Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle. 2014; 13(9):1384-91.

View in: PubMed
Landry BD, Doyle JP, Toczyski DP, Benanti JA. F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012; 8(7):e1002851.

View in: PubMed
Benanti JA. Coordination of cell growth and division by the ubiquitin-proteasome system. Semin Cell Dev Biol. 2012 Jul; 23(5):492-8.

View in: PubMed
Pereira BP, Zhou Y, Gupta A, Leong DT, Aung KZ, Ling L, Pho RW, Galindo M, Salto-Tellez M, Stein GS, Cool SM, van Wijnen AJ, Nathan SS. Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). J Cell Physiol. 2009 Dec; 221(3):778-88.

View in: PubMed
Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 2009 Feb 19; 113(8):1689-98.

View in: PubMed

People

Explore

Similar Concepts

Top Journals