"Separase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
| Descriptor ID |
D064247
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| MeSH Number(s) |
D08.811.277.656.262.500.792 D08.811.277.656.300.200.792 D12.776.167.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Separase".
Below are MeSH descriptors whose meaning is more specific than "Separase".
This graph shows the total number of publications written about "Separase" by people in this website by year, and whether "Separase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Separase" by people in Profiles.
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Yang X, Boateng KA, Yuan L, Wu S, Baskin TI, Makaroff CA. The radially swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes. PLoS One. 2011 Apr 29; 6(4):e19459.
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Wu S, Scheible WR, Schindelasch D, Van Den Daele H, De Veylder L, Baskin TI. A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability. Development. 2010 Mar; 137(6):953-61.
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Yang X, Boateng KA, Strittmatter L, Burgess R, Makaroff CA. Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis. Plant Physiol. 2009 Sep; 151(1):323-33.
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Rappleye CA, Tagawa A, Lyczak R, Bowerman B, Aroian RV. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Dev Cell. 2002 Feb; 2(2):195-206.