Dopamine Plasma Membrane Transport Proteins

"Dopamine Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.

Descriptor ID	D050483
MeSH Number(s)	D12.776.157.530.450.625.124 D12.776.157.530.562.374.500.500 D12.776.157.530.937.500 D12.776.543.585.450.625.124 D12.776.543.585.562.374.500.500 D12.776.543.585.937.500
Concept/Terms	Dopamine Plasma Membrane Transport Proteins Dopamine Plasma Membrane Transport Proteins Dopamine Transporter Transporter, Dopamine SLC6A3 Protein Protein, SLC6A3 Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3 Protein Dopamine Transporter Proteins Transporter Proteins, Dopamine Dopamine Carriers Carriers, Dopamine DAT Dopamine Transporter Proteins Neurotransmitter Transport Proteins, Dopamine-Specific Neurotransmitter Transport Proteins, Dopamine Specific Neurotransmitter Transporters, Dopamine-Specific Dopamine-Specific Neurotransmitter Transporters Neurotransmitter Transporters, Dopamine Specific Transporters, Dopamine-Specific Neurotransmitter DAT Dopamine Transporter Dopamine Transporter, DAT Transporter, DAT Dopamine Dopamine Plasma Membrane Transporter Proteins Dopamine Uptake Complex Dopamine Uptake Complex

Below are MeSH descriptors whose meaning is more general than "Dopamine Plasma Membrane Transport Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Symporters [D12.776.157.530.450.625]
Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.450.625.124]
Neurotransmitter Transport Proteins [D12.776.157.530.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.157.530.562.374]
Catecholamine Plasma Membrane Transport Proteins [D12.776.157.530.562.374.500]
Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.562.374.500.500]
Solute Carrier Proteins [D12.776.157.530.937]
Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Symporters [D12.776.543.585.450.625]
Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.124]
Neurotransmitter Transport Proteins [D12.776.543.585.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.543.585.562.374]
Catecholamine Plasma Membrane Transport Proteins [D12.776.543.585.562.374.500]
Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.562.374.500.500]
Solute Carrier Proteins [D12.776.543.585.937]
Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]

Below are MeSH descriptors whose meaning is related to "Dopamine Plasma Membrane Transport Proteins".

Below are MeSH descriptors whose meaning is more specific than "Dopamine Plasma Membrane Transport Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dopamine Plasma Membrane Transport Proteins" by people in this website by year, and whether "Dopamine Plasma Membrane Transport Proteins" was a major or minor topic of these publications.

Bar chart showing 31 publications over 19 distinct years, with a maximum of 4 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	0	2	2
2006	1	0	1
2007	1	0	1
2008	3	1	4
2009	0	2	2
2010	2	0	2
2011	3	0	3
2012	1	1	2
2013	1	0	1
2014	1	1	2
2015	1	0	1
2016	1	0	1
2017	1	0	1
2019	1	0	1
2020	2	1	3
2021	1	0	1
2023	1	0	1
2025	1	0	1

Below are the most recent publications written about "Dopamine Plasma Membrane Transport Proteins" by people in Profiles.

Bolden NC, Pavchinskiy RG, Melikian HE. Dopamine transporter endocytic trafficking: Neuronal mechanisms and potential impact on DA-dependent behaviors. J Neurochem. 2025 Jan; 169(1):e16284.

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Kearney PJ, Bolden NC, Kahuno E, Conklin TL, Martin GE, Lubec G, Melikian HE. Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function. J Biol Chem. 2023 02; 299(2):102900.

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Fagan RR, Kearney PJ, Luethi D, Bolden NC, Sitte HH, Emery P, Melikian HE. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Mol Psychiatry. 2021 12; 26(12):7793-7802.

View in: PubMed
Fagan RR, Kearney PJ, Melikian HE. In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home. Neurochem Res. 2020 Jun; 45(6):1335-1343.

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Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. J Biol Chem. 2020 04 17; 295(16):5229-5244.

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Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K. Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study. Mov Disord. 2020 05; 35(5):833-844.

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Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten SJ, Bressman S, Marek K. Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study. Lancet Neurol. 2020 01; 19(1):71-80.

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Wu S, Fagan RR, Uttamapinant C, Lifshitz LM, Fogarty KE, Ting AY, Melikian HE. The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach. J Neurosci. 2017 09 27; 37(39):9438-9452.

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Sweeney CG, Tremblay BP, Stockner T, Sitte HH, Melikian HE. Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities. J Biol Chem. 2017 01 27; 292(4):1302-1309.

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Wu S, Bellve KD, Fogarty KE, Melikian HE. Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15480-5.

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