Guanine Nucleotide Exchange Factors

"Guanine Nucleotide Exchange Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.

Descriptor ID	D020662
MeSH Number(s)	D12.644.360.325.300 D12.776.476.325.300
Concept/Terms	Guanine Nucleotide Exchange Factors Guanine Nucleotide Exchange Factors Guanine-Nucleotide-Releasing Factor Guanine Nucleotide Releasing Factor GDP Dissociation Factor GDP-GTP Exchange Protein GDP GTP Exchange Protein GDP Dissociation Stimulators GDP-GTP Reversing Factors Factors, GDP-GTP Reversing GDP GTP Reversing Factors Reversing Factors, GDP-GTP Guanine Nucleotide Releasing Factors GDP Exchange Factors Exchange Factors, GDP Factors, GDP Exchange Guanine Nucleotide Exchange Factor

Below are MeSH descriptors whose meaning is more general than "Guanine Nucleotide Exchange Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
GTP-Binding Protein Regulators [D12.644.360.325]
Guanine Nucleotide Exchange Factors [D12.644.360.325.300]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
GTP-Binding Protein Regulators [D12.776.476.325]
Guanine Nucleotide Exchange Factors [D12.776.476.325.300]

Below are MeSH descriptors whose meaning is related to "Guanine Nucleotide Exchange Factors".

Below are MeSH descriptors whose meaning is more specific than "Guanine Nucleotide Exchange Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Guanine Nucleotide Exchange Factors" by people in this website by year, and whether "Guanine Nucleotide Exchange Factors" was a major or minor topic of these publications.

Bar chart showing 52 publications over 24 distinct years, with a maximum of 4 publications in 2005 and 2014 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	1	3
2000	2	0	2
2001	2	0	2
2002	1	0	1
2003	1	0	1
2004	1	1	2
2005	2	2	4
2006	1	0	1
2007	2	0	2
2008	2	0	2
2009	0	1	1
2010	2	1	3
2011	2	1	3
2012	2	0	2
2013	0	1	1
2014	3	1	4
2015	2	2	4
2016	2	0	2
2017	2	0	2
2018	1	0	1
2019	2	1	3
2020	1	1	2
2021	0	2	2
2023	1	1	2

Below are the most recent publications written about "Guanine Nucleotide Exchange Factors" by people in Profiles.

Zhang B, Chen S, Yin X, McBride CD, Gertie JA, Yurieva M, Bielecka AA, Hoffmann B, Travis Hinson J, Grassmann J, Xu L, Siniscalco ER, Soldatenko A, Hoyt L, Joseph J, Norton EB, Uthaman G, Palm NW, Liu E, Eisenbarth SC, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunol. 2024 Jun; 17(3):431-449.

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Gutierrez-Ruiz OL, Johnson KM, Krueger EW, Nooren RE, Cruz-Reyes N, Heppelmann CJ, Hogenson TL, Fernandez-Zapico ME, McNiven MA, Razidlo GL. Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. Cell Rep. 2023 09 26; 42(9):113042.

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Perica T, Mathy CJP, Xu J, Jang G?, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T. Systems-level effects of allosteric perturbations to a model molecular switch. Nature. 2021 11; 599(7883):152-157.

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Duan J, Lambright DG. Propelling COPII vesicle biogenesis at the endoplasmic reticulum. Structure. 2021 08 05; 29(8):779-781.

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Li J, Lambright DG, Hsu VW. Coordination of Grp1 recruitment mechanisms by its phosphorylation. Mol Biol Cell. 2020 12 01; 31(25):2816-2825.

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Mendoza-Ferreira N, Karakaya M, Cengiz N, Beijer D, Brigatti KW, Gonzaga-Jauregui C, Fuhrmann N, H?lker I, Thelen MP, Zetzsche S, Rombo R, Puffenberger EG, De Jonghe P, Deconinck T, Zuchner S, Strauss KA, Carson V, Schrank B, Wunderlich G, Baets J, Wirth B. De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation. Am J Hum Genet. 2020 10 01; 107(4):763-777.

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Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science. 2019 08 30; 365(6456).

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Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. FEBS Open Bio. 2019 09; 9(9):1589-1602.

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Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Sch?rmann A, Wilhelmi I, Yohe ME, Kahn RA. ARF GTPases and their GEFs and GAPs: concepts and challenges. Mol Biol Cell. 2019 05 15; 30(11):1249-1271.

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Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick NG, Agnello E, O'Connell R, Stratton MM, Yasuda R, Hayashi Y. Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP. Neuron. 2019 06 19; 102(6):1199-1210.e6.

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