Mitogen-Activated Protein Kinase 9

"Mitogen-Activated Protein Kinase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 48 and 54 KD exist due to multiple ALTERNATIVE SPLICING.

Descriptor ID	D048056
MeSH Number(s)	D08.811.913.696.620.682.700.567.374.750 D12.644.360.450.340.750 D12.776.476.450.340.750
Concept/Terms	Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinase 9 Mitogen Activated Protein Kinase 9 Stress-Activated Protein Kinase JNK2 Stress Activated Protein Kinase JNK2 JNK2 Kinase c-jun Kinase-2 Kinase-2, c-jun c jun Kinase 2 MAPK9 Mitogen-Activated Protein Kinase MAPK9 Mitogen Activated Protein Kinase c-jun N-terminal Kinase 2 c jun N terminal Kinase 2 JNK2 Stress-Activated Protein Kinase JNK2 Stress Activated Protein Kinase

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 9".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
JNK Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.374]
Mitogen-Activated Protein Kinase 9 [D08.811.913.696.620.682.700.567.374.750]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
JNK Mitogen-Activated Protein Kinases [D12.644.360.450.340]
Mitogen-Activated Protein Kinase 9 [D12.644.360.450.340.750]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
JNK Mitogen-Activated Protein Kinases [D12.776.476.450.340]
Mitogen-Activated Protein Kinase 9 [D12.776.476.450.340.750]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinase 9".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 9".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 9" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 9" was a major or minor topic of these publications.

Bar chart showing 30 publications over 19 distinct years, with a maximum of 4 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2000	0	1	1
2002	0	4	4
2003	0	2	2
2004	0	1	1
2005	1	0	1
2006	1	1	2
2007	2	0	2
2009	1	1	2
2010	3	0	3
2011	1	1	2
2012	1	0	1
2013	0	1	1
2015	2	0	2
2018	1	0	1
2019	1	0	1
2020	1	0	1
2021	1	0	1
2025	1	0	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinase 9" by people in Profiles.

Mohamed MR, Zhao G, Volkert I, Molinaro A, Schneider CV, Strnad P, Hengstler JG, Xu C, Davis RJ, Schneider KM, Cubero FJ, Trautwein C. Differential Protective Roles of c-Jun N-terminal Kinase-2 in Nonparenchymal Liver Cells and Hepatocytes During Cholestasis. Cell Mol Gastroenterol Hepatol. 2025; 19(11):101588.

View in: PubMed
Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711.

View in: PubMed
Manieri E, Folgueira C, Rodr?guez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, G?mez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16492-16499.

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Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148.

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Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018; 14(9):1586-1595.

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Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C. Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury. Gastroenterology. 2016 Apr; 150(4):968-81.

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Nistic? R, Florenzano F, Mango D, Ferraina C, Grilli M, Di Prisco S, Nobili A, Saccucci S, D'Amelio M, Morbin M, Marchi M, Mercuri NB, Davis RJ, Pittaluga A, Feligioni M. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. Sci Rep. 2015 Mar 12; 5:9035.

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You H, Padmashali RM, Ranganathan A, Lei P, Girnius N, Davis RJ, Andreadis ST. JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues. J Cell Sci. 2013 Jun 15; 126(Pt 12):2718-29.

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Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11; 339(6116):218-22.

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Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Res. 2012 Jan 15; 72(2):472-81.

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