Zinc Fingers

"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

Descriptor ID	D016335
MeSH Number(s)	G02.111.570.820.709.275.500.985
Concept/Terms	Zinc Fingers Zinc Fingers Finger, Zinc Fingers, Zinc Zinc Finger Zinc Finger Motifs Motif, Zinc Finger Motifs, Zinc Finger Zinc Finger Motif Zinc Finger DNA-Binding Domains Zinc Finger DNA-Binding Domains Zinc Finger DNA Binding Domains

Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Amino Acid Motifs [G02.111.570.820.709.275.500]
Zinc Fingers [G02.111.570.820.709.275.500.985]

Below are MeSH descriptors whose meaning is related to "Zinc Fingers".

Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.

Bar chart showing 73 publications over 28 distinct years, with a maximum of 7 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	1	2	3
1999	1	2	3
2000	1	4	5
2001	0	2	2
2002	3	4	7
2003	2	0	2
2004	2	4	6
2005	0	1	1
2006	0	1	1
2007	1	1	2
2008	1	2	3
2009	0	1	1
2010	2	4	6
2011	1	2	3
2012	2	1	3
2013	2	3	5
2014	1	2	3
2015	0	3	3
2016	0	1	1
2017	0	1	1
2018	0	1	1
2019	0	1	1
2020	0	1	1
2021	1	1	2
2024	1	0	1
2025	1	2	3

Below are the most recent publications written about "Zinc Fingers" by people in Profiles.

Mathews EW, Coffey SR, G?rtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Bennett CF, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Beuzer P, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB. Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding. Nat Commun. 2025 Nov 14; 16(1):10009.

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Ertekin A, Noronha ST, Darko C, Massi F, Ryder SP. A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability. RNA. 2025 10 16; 31(11):1575-1588.

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Iwanowicz A, Boudi A, Seeley C, Sapp E, Miller R, Liu S, Chase K, Shing K, Batista AR, Siena-Esteves M, Aronin N, DiFiglia M, Kegel-Gleason KB. Intrastriatal Delivery of a Zinc Finger Protein Targeting the Mutant HTT Gene Allele Obviates Lipid Phenotypes in Brain and Plasma in Huntington's Disease?Mice. Hum Gene Ther. 2025 08; 36(15-16):1083-1094.

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Ertekin A, Morgan BR, Ryder SP, Massi F. Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity. Biochemistry. 2024 10 15; 63(20):2632-2647.

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Huang L, Liu P, Yang Q, Wang YX. The KRAB Domain-Containing Protein ZFP961 Represses Adipose Thermogenesis and Energy Expenditure through Interaction with PPARa. Adv Sci (Weinh). 2022 01; 9(2):e2102949.

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Shen Y, Li R, Teichert K, Montbleau KE, Verboon JM, Voit RA, Sankaran VG. Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing. PLoS Genet. 2021 10; 17(10):e1009835.

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Tavella D, Ertekin A, Schaal H, Ryder SP, Massi F. A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5. Biophys J. 2020 04 21; 118(8):2001-2014.

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Rovira Gonzalez YI, Moyer AL, LeTexier NJ, Bratti AD, Feng S, Sun C, Liu T, Mula J, Jha P, Iyer SR, Lovering RM, O'Rourke B, Noh HL, Suk S, Kim JK, Essien Umanah GK, Wagner KR. Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice. JCI Insight. 2019 10 17; 4(20).

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Farley JE, Burdett TC, Barria R, Neukomm LJ, Kenna KP, Landers JE, Freeman MR. Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):1358-1363.

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Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henr?quez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, H?rtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain. 2017 Dec 01; 140(12):3252-3268.

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