"Helix-Loop-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
| Descriptor ID |
D018257
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.360
|
| Concept/Terms |
Helix-Loop-Helix Motifs- Helix-Loop-Helix Motifs
- Helix Loop Helix Motifs
- Motif, Helix-Loop-Helix
- Helix-Loop-Helix Domains
- Helix Loop Helix Domains
- Helix-Loop-Helix Motif
- Helix Loop Helix Motif
- Helix-Loop-Helix Domain
- Helix Loop Helix Domain
- HLH Motifs
- HLH Motif
- Motif, HLH
- Motifs, HLH
- Motifs, Helix-Loop-Helix
- Motifs, Helix Loop Helix
|
Below are MeSH descriptors whose meaning is more general than "Helix-Loop-Helix Motifs".
Below are MeSH descriptors whose meaning is more specific than "Helix-Loop-Helix Motifs".
This graph shows the total number of publications written about "Helix-Loop-Helix Motifs" by people in this website by year, and whether "Helix-Loop-Helix Motifs" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 2 | 3 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Helix-Loop-Helix Motifs" by people in Profiles.
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Hovhannisyan H, Zhang Y, Hassan MQ, Wu H, Glackin C, Lian JB, Stein JL, Montecino M, Stein GS, van Wijnen AJ. Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene. J Cell Physiol. 2013 Feb; 228(2):313-21.
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Wang H, San Agustin JT, Witman GB, Kilpatrick DL. Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression. Mol Cell Biol. 2004 Dec; 24(24):10681-8.
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Johnson SA, Mar?n-Bivens CL, Miele M, Coyle CA, Fissore R, Good DJ. The Nhlh2 transcription factor is required for female sexual behavior and reproductive longevity. Horm Behav. 2004 Nov; 46(4):420-7.
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Maeda Y, Tsuji K, Nifuji A, Noda M. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J Cell Biochem. 2004 Oct 01; 93(2):337-44.
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Pavlath GK, Dominov JA, Kegley KM, Miller JB. Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factor MRF4. Am J Pathol. 2003 May; 162(5):1685-91.
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Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol. 2003 Jan; 23(1):259-71.
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Roy K, de la Serna IL, Imbalzano AN. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. J Biol Chem. 2002 Sep 13; 277(37):33818-24.
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O'Neil J, Billa M, Oikemus S, Kelliher M. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene. 2001 Jun 28; 20(29):3897-905.
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Quong MW, Harris DP, Swain SL, Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 1999 Nov 15; 18(22):6307-18.
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Shearman LP, Zylka MJ, Reppert SM, Weaver DR. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus. Neuroscience. 1999 Mar; 89(2):387-97.