"Helix-Turn-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
| Descriptor ID |
D019077
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.360.360
|
| Concept/Terms |
Helix-Turn-Helix Motifs- Helix-Turn-Helix Motifs
- Helix Turn Helix Motifs
- Helix-Turn-Helix Motif
- Motif, Helix-Turn-Helix
- Motifs, Helix-Turn-Helix
- Motifs, Helix Turn Helix
- HTH Motifs
- HTH Motif
- Motif, HTH
- Motifs, HTH
|
Below are MeSH descriptors whose meaning is more general than "Helix-Turn-Helix Motifs".
Below are MeSH descriptors whose meaning is more specific than "Helix-Turn-Helix Motifs".
This graph shows the total number of publications written about "Helix-Turn-Helix Motifs" by people in this website by year, and whether "Helix-Turn-Helix Motifs" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Helix-Turn-Helix Motifs" by people in Profiles.
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Zhang Y, Hassan MQ, Li ZY, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation. J Cell Biochem. 2008 Oct 01; 105(2):487-96.
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Zhu Z, Dumas JJ, Lietzke SE, Lambright DG. A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release. Biochemistry. 2001 Mar 13; 40(10):3027-36.