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    Michael J Lee PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentProgram in Molecular Medicine
    AddressUniversity of Massachusetts Medical School
    368 Plantation Street, AS5-1047
    Worcester MA 01655
    Phone774-455-3870
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentSystems Biology

        Overview 
        Narrative

        Michael Lee received his BS degree in Cell Biology from the University of Washington in 2002, where he studied the function and regulation of non-receptor tyrosine kinases in the immune system, first in the laboratory of Steven D. Levin, and subsequently with Michael J. Bevan. Working in Henrik G. Dohlman's lab, Mike went on to receive his PhD in Pharmacology from the University of North Carolina at Chapel Hill in 2008 for work studying the subcellular localization and mechanisms of activation of heterotrimeric G proteins. For postdoctoral training, Mike moved to the Koch Institute for Integrative Cancer Research at MIT, where he worked with Michael B. Yaffe, studying crosstalk between growth factor and DNA damage signaling networks. Mike joined the Program in Systems Biology in late 2013. His lab studies complex behaviors of signaling networks that control cell death, how network state and network architecture are perturbed in various forms of cancer, and how these perturbations contribute to treatment responses. They aim to identify guiding principles for designing rational combination drug therapies for breast and other types of cancer.

        Please click on links below for access to websites:

        Lab Info: The Lee Lab


        Department: Program in Systems Biology


        Affiliations:

        Program in Molecular Medicine

        Department of Cancer Biology

         



        Rotation Projects

        We are always very excited to have students rotate in the Lee Lab! Projects are available for those interested in developing an experimental and/or computational skill set, and those interested in training across these disciplines are always encouraged to do so. By rotating in the Lee Lab, you will gain expertise in a variety of quantitative high-throughput techniques in the area of proteomics, signal transduction, network biology, and genomics. We aim to actively promote an interactive and fun atmosphere. Students will participate in various lab and PSB functions, including weekly lab meetings, weekly Systems Biology journal club, and at the end of the rotation, students will present their work to the lab/department.



        Post Docs
        A postdoctoral position is available within the Lee Lab.  Please see our webpage for more information (http://labs.umassmed.edu/LeeLab). Application materials can be sent directly to Dr. Lee, and please have 3 letters of reference sent by email directly to Dr. Lee, including the applicants name in the subject line.  

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014; 7(325):ra44.
          View in: PubMed
        2. Singh M, Kaur R, Lee MJ, Pickering RT, Sharma VM, Puri V, Kandror KV. Fat-specific Protein 27 Inhibits Lipolysis by Facilitating the Inhibitory Effect of Transcription Factor Egr1 on Transcription of Adipose Triglyceride Lipase. J Biol Chem. 2014 May 23; 289(21):14481-7.
          View in: PubMed
        3. Grahn TH, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V. Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes. J Biol Chem. 2014 Apr 25; 289(17):12029-39.
          View in: PubMed
        4. Lee MJ, Fried SK. Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol. 2014; 538:49-65.
          View in: PubMed
        5. Lee MJ, Pickering RT, Puri V. Prolonged efficiency of siRNA-mediated gene silencing in primary cultures of human preadipocytes and adipocytes. Obesity (Silver Spring). 2014 Apr; 22(4):1064-9.
          View in: PubMed
        6. Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. Mol Cell Biol. 2013 Sep; 33(18):3659-66.
          View in: PubMed
        7. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50.
          View in: PubMed
        8. Karastergiou K, Fried SK, Xie H, Lee MJ, Divoux A, Rosencrantz MA, Chang RJ, Smith SR. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J Clin Endocrinol Metab. 2013 Jan; 98(1):362-71.
          View in: PubMed
        9. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94.
          View in: PubMed
        10. Lee MJ, Wu Y, Fried SK. A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes. Obesity (Silver Spring). 2012 Dec; 20(12):2334-40.
          View in: PubMed
        11. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012; 8:568.
          View in: PubMed
        12. Lee MJ, Wu Y, Fried SK. Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4):371-6.
          View in: PubMed
        13. Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG. G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem. 2009 Mar 27; 284(13):8940-50.
          View in: PubMed
        14. Lee MJ, Dohlman HG. Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol. 2008 Feb 12; 18(3):211-5.
          View in: PubMed
        15. Wang Y, Marotti LA, Lee MJ, Dohlman HG. Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. J Biol Chem. 2005 Jan 7; 280(1):284-91.
          View in: PubMed
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