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    Phillip D Zamore PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentBiochemistry and Molecular Pharmacology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB-822
    Worcester MA 01605
    Phone508-856-2191
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentRNA Therapeutics Institute

        Overview 
        Narrative

        Please visit my lab website!

        Phillip D. Zamore received his A.B. (1986) and his Ph.D. (1992) from the Department of Biochemistry and Molecular Biology at Harvard University. He received a Life Sciences Research Foundation and a Charles H. Hood Fellowship to do postdoctoral work at the Whitehead Institute at the Massachusetts Institute of Technology. He joined the Department of Biochemistry and Molecular Biology at the University of Massachusetts Medical School as a faculty member in November 1999 and is a 2000 Pew Scholar in the Biomedical Sciences. In 2002, he became a W.M. Keck Foundation Young Scholar in Medical Research.

        Photo: Phillip D. ZamoreGretchen Stone Cook Professor of Biomedical Sciences, Co-Director RNA Therapeutics Institute (RTI), Howard Hughes Medical Institute Investigator

        Dissecting the RNAi and miRNA pathways

        RNA interference (RNAi) is the surprising ability of double-stranded RNA — but not antisense RNA — to target a corresponding mRNA for destruction. RNAi likely represents an ancient cellular defense against viral infection, a mechanism for preventing the ‘jumping’ of transposons, and perhaps even a pathway by which cells regulate endogenous genes. RNAi has become an important tool for studying gene function in worms, flies, and cultured mammalian cells, and may lead to new drugs to treat human genetic disorders. Our laboratory studies the mechanism that underlies RNAi in plants and animals. The laboratory combines biochemistry with genetics and cell biology to understand the biological functions and the molecular basis of the RNAi pathway.

        We also study a related pathway, the microRNA (miRNA) pathway. miRNAs are small RNAs found in animals and plants; they regulate gene expression by mechanisms intimately related to those that underlie RNAi. We are particularly interested in how miRNAs find identify their target genes and how they repress their expression.

        Understanding the molecular mechanisms of post-transcriptional gene regulation.

        How do animal embryos regulate the localization, translation, and stability of mRNAs?

        In Drosophila, mRNA encoding the transcription factor, hunchback, is present throughout the embryo, but is translated into protein only in the anterior half of the cell. Two proteins, NANOS and PUMILIO. are required to repress hunchback translation in the posterior half of the fly embryo. PUMILIO binds RNA through a novel RNA-binding motif found in proteins that control developmental decisions in yeast, slime mold, and worms, and is more than 80% identical to a protein of unknown function in humans. A major goal of our laboratory is to learn how PUMILIO and NANOS control hunchback mRNA translation and to determine the biological role of the human PUMILIO protein.

        For more information, visit his Howard Hughes Medical Institute web page at: http://www.hhmi.org/research/investigators/zamore_bio.html



        Rotation Projects

        Potential Rotation Projects

        Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.




        Post Docs
        A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Han BW, Zamore PD. piRNAs. Curr Biol. 2014 Aug 18; 24(16):R730-3.
          View in: PubMed
        2. Babcock GJ, Iyer S, Smith HL, Wang Y, Rowley K, Ambrosino DM, Zamore PD, Pierce BG, Molrine DC, Weng Z. High-throughput sequencing analysis of post-liver transplantation HCV e2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody. PLoS One. 2014; 9(6):e100325.
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        3. Broderick JA, Zamore PD. Competitive Endogenous RNAs Cannot Alter MicroRNA Function In Vivo. Mol Cell. 2014 Jun 5; 54(5):711-3.
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        4. Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE. The HP1 Homolog Rhino Anchors a Nuclear Complex that Suppresses piRNA Precursor Splicing. Cell. 2014 Jun 5; 157(6):1353-63.
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        5. Fukunaga R, Zamore PD. A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle. 2014 Jun 1; 13(11):1671-6.
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        6. Moran Y, Fredman D, Praher D, Li XZ, Wee LM, Rentzsch F, Zamore PD, Technau U, Seitz H. Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res. 2014 Apr; 24(4):651-63.
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        7. Zhang Z, Koppetsch BS, Wang J, Tipping C, Weng Z, Theurkauf WE, Zamore PD. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J. 2014 Mar 18; 33(6):536-9.
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        8. Fukunaga R, Colpan C, Han BW, Zamore PD. Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J. 2014 Feb 18; 33(4):371-84.
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        9. Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 2013 Aug; 14(8):475-88.
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        10. Li XZ, Roy CK, Moore MJ, Zamore PD. Defining piRNA primary transcripts. Cell Cycle. 2013 Jun 1; 12(11):1657-8.
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        11. Ge DT, Zamore PD. Small RNA-directed silencing: the fly finds its inner fission yeast? Curr Biol. 2013 Apr 22; 23(8):R318-20.
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        12. Li XZ, Roy CK, Dong X, Bolcun-Filas E, Wang J, Han BW, Xu J, Moore MJ, Schimenti JC, Weng Z, Zamore PD. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell. 2013 Apr 11; 50(1):67-81.
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        13. Chung RT, Gordon FD, Curry MP, Schiano TD, Emre S, Corey K, Markmann JF, Hertl M, Pomposelli JJ, Pomfret EA, Florman S, Schilsky M, Broering TJ, Finberg RW, Szabo G, Zamore PD, Khettry U, Babcock GJ, Ambrosino DM, Leav B, Leney M, Smith HL, Molrine DC. Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study. Am J Transplant. 2013 Apr; 13(4):1047-54.
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        14. Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. J Huntingtons Dis. 2013 Jan; 2(4):491-500.
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        15. Zhang Z, Theurkauf WE, Weng Z, Zamore PD. Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence. 2012; 3(1):9.
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        16. Flores-Jasso CF, Salomon WE, Zamore PD. Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA. 2013 Feb; 19(2):271-9.
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        17. Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell. 2012 Nov 21; 151(5):1055-67.
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        18. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch BS, Schultz N, Vreven T, Meignin C, Davis I, Zamore PD, Weng Z, Theurkauf WE. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell. 2012 Nov 9; 151(4):871-84.
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        19. Fukunaga R, Han BW, Hung JH, Xu J, Weng Z, Zamore PD. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell. 2012 Oct 26; 151(3):533-46.
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        20. Zamore PD. RNA: methods and protocols - a new series. Silence. 2012; 3(1):7.
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        21. Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012 Apr; 9(4):403-9.
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        22. Mueller C, Tang Q, Gruntman A, Blomenkamp K, Teckman J, Song L, Zamore PD, Flotte TR. Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Mol Ther. 2012 Mar; 20(3):590-600.
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        23. Khurana JS, Wang J, Xu J, Koppetsch BS, Thomson TC, Nowosielska A, Li C, Zamore PD, Weng Z, Theurkauf WE. Adaptation to P element transposon invasion in Drosophila melanogaster. Cell. 2011 Dec 23; 147(7):1551-63.
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        24. Zhang Z, Xu J, Koppetsch BS, Wang J, Tipping C, Ma S, Weng Z, Theurkauf WE, Zamore PD. Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell. 2011 Nov 18; 44(4):572-84.
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        25. Han BW, Hung JH, Weng Z, Zamore PD, Ameres SL. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol. 2011 Nov 22; 21(22):1878-87.
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        26. Broderick JA, Salomon WE, Ryder SP, Aronin N, Zamore PD. Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA. 2011 Oct; 17(10):1858-69.
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        27. Cenik ES, Zamore PD. Argonaute proteins. Curr Biol. 2011 Jun 21; 21(12):R446-9.
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        28. Seitz H, Tushir JS, Zamore PD. A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence. 2011; 2:4.
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        29. Zamore PD, Ma S. Isolation of Drosophila melanogaster testes. J Vis Exp. 2011; (51).
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        30. Broderick JA, Zamore PD. MicroRNA therapeutics. Gene Ther. 2011 Dec; 18(12):1104-10.
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        31. Cenik ES, Fukunaga R, Lu G, Dutcher R, Wang Y, Tanaka Hall TM, Zamore PD. Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell. 2011 Apr 22; 42(2):172-84.
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        32. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell. 2010 Dec 23; 143(7):1084-96.
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        33. Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, Perrimon N, Lai EC. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res. 2011 Feb; 21(2):203-15.
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        34. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther. 2011 Mar; 19(3):526-35.
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        35. Ameres SL, Hung JH, Xu J, Weng Z, Zamore PD. Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA. 2011 Jan; 17(1):54-63.
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        36. Zamore PD. Somatic piRNA biogenesis. EMBO J. 2010 Oct 6; 29(19):3219-21.
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        37. Ameres SL, Horwich MD, Hung JH, Xu J, Ghildiyal M, Weng Z, Zamore PD. Target RNA-directed trimming and tailing of small silencing RNAs. Science. 2010 Jun 18; 328(5985):1534-9.
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        38. Baulcombe DC, Zamore PD. Welcome to silence. Silence. 2010; 1(1):1.
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        39. Ghildiyal M, Xu J, Seitz H, Weng Z, Zamore PD. Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA. 2010 Jan; 16(1):43-56.
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        40. Tushir JS, Zamore PD, Zhang Z. SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009 Nov 13; 139(4):830-830.e1.
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        41. Tushir JS, Zamore PD, Zhang Z. SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009 Oct 30; 139(3):634, 634.e1.
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        42. Pfister EL, Zamore PD. Huntington's disease: silencing a brutal killer. Exp Neurol. 2009 Dec; 220(2):226-9.
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        43. Klattenhoff C, Xi H, Li C, Lee S, Xu J, Khurana JS, Zhang F, Schultz N, Koppetsch BS, Nowosielska A, Seitz H, Zamore PD, Weng Z, Theurkauf WE. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell. 2009 Sep 18; 138(6):1137-49.
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        44. Kadener S, Menet JS, Sugino K, Horwich MD, Weissbein U, Nawathean P, Vagin VV, Zamore PD, Nelson SB, Rosbash M. A role for microRNAs in the Drosophila circadian clock. Genes Dev. 2009 Sep 15; 23(18):2179-91.
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        45. Izaurralde E, Zamore PD. Nucleus and gene expression. Curr Opin Cell Biol. 2009 Jun; 21(3):331-4.
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        46. Barringhaus KG, Zamore PD. MicroRNAs: regulating a change of heart. Circulation. 2009 Apr 28; 119(16):2217-24.
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        47. Li C, Vagin VV, Lee S, Xu J, Ma S, Xi H, Seitz H, Horwich MD, Syrzycka M, Honda BM, Kittler EL, Zapp ML, Klattenhoff C, Schulz N, Theurkauf WE, Weng Z, Zamore PD. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell. 2009 May 1; 137(3):509-21.
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        48. Pfister EL, Kennington L, Straubhaar J, Wagh S, Liu W, DiFiglia M, Landwehrmeyer B, Vonsattel JP, Zamore PD, Aronin N. Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol. 2009 May 12; 19(9):774-8.
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        49. Ghildiyal M, Zamore PD. Small silencing RNAs: an expanding universe. Nat Rev Genet. 2009 Feb; 10(2):94-108.
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        50. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3.
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        51. Rossi J, Zamore P, Kay MA. Wandering eye for RNAi. Nat Med. 2008 Jun; 14(6):611.
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        52. Ghildiyal M, Seitz H, Horwich MD, Li C, Du T, Lee S, Xu J, Kittler EL, Zapp ML, Weng Z, Zamore PD. Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science. 2008 May 23; 320(5879):1077-81.
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        53. Seitz H, Ghildiyal M, Zamore PD. Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol. 2008 Jan 22; 18(2):147-51.
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        54. Horwich MD, Zamore PD. Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc. 2008; 3(10):1537-49.
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        55. DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17204-9.
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        56. Matranga C, Zamore PD. Small silencing RNAs. Curr Biol. 2007 Sep 18; 17(18):R789-93.
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        57. Du T, Zamore PD. Beginning to understand microRNA function. Cell Res. 2007 Aug; 17(8):661-3.
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        58. Förstemann K, Horwich MD, Wee L, Tomari Y, Zamore PD. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell. 2007 Jul 27; 130(2):287-97.
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        59. Tomari Y, Du T, Zamore PD. Sorting of Drosophila small silencing RNAs. Cell. 2007 Jul 27; 130(2):299-308.
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        60. Horwich MD, Li C, Matranga C, Vagin V, Farley G, Wang P, Zamore PD. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol. 2007 Jul 17; 17(14):1265-72.
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        61. Zamore PD. RNA silencing: genomic defence with a slice of pi. Nature. 2007 Apr 19; 446(7138):864-5.
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        62. Zamore PD. RNA interference: big applause for silencing in Stockholm. Cell. 2006 Dec 15; 127(6):1083-6.
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        63. Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2006 Sep 8; 2(9):e140.
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        64. Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. A distinct small RNA pathway silences selfish genetic elements in the germline. Science. 2006 Jul 21; 313(5785):320-4.
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        65. Seitz H, Zamore PD. Rethinking the microprocessor. Cell. 2006 Jun 2; 125(5):827-9.
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        66. Sigova A, Vagin V, Zamore PD. Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on. Cold Spring Harb Symp Quant Biol. 2006; 71:335-41.
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        67. Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 2005 Nov 18; 123(4):607-20.
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        68. Du T, Zamore PD. microPrimer: the biogenesis and function of microRNA. Development. 2005 Nov; 132(21):4645-52.
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        69. Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005 Sep 2; 309(5740):1519-24.
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        70. Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD. Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 2005 Jul; 3(7):e236.
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        71. Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev. 2005 Mar 1; 19(5):517-29.
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        72. Tomari Y, Zamore PD. MicroRNA biogenesis: drosha can't cut it without a partner. Curr Biol. 2005 Jan 26; 15(2):R61-4.
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        73. Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD. A protein sensor for siRNA asymmetry. Science. 2004 Nov 19; 306(5700):1377-80.
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        74. Sigova A, Rhind N, Zamore PD. A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes Dev. 2004 Oct 1; 18(19):2359-67.
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        75. Mallory AC, Reinhart BJ, Jones-Rhoades MW, Tang G, Zamore PD, Barton MK, Bartel DP. MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J. 2004 Aug 18; 23(16):3356-64.
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        76. Haley B, Zamore PD. Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol. 2004 Jul; 11(7):599-606.
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        77. Schwarz DS, Tomari Y, Zamore PD. The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol. 2004 May 4; 14(9):787-91.
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        78. Tomari Y, Du T, Haley B, Schwarz DS, Bennett R, Cook HA, Koppetsch BS, Theurkauf WE, Zamore PD. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell. 2004 Mar 19; 116(6):831-41.
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        79. Zamore PD. Plant RNAi: How a viral silencing suppressor inactivates siRNA. Curr Biol. 2004 Mar 9; 14(5):R198-200.
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        80. Hutvágner G, Simard MJ, Mello CC, Zamore PD. Sequence-specific inhibition of small RNA function. PLoS Biol. 2004 Apr; 2(4):E98.
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        81. Matranga C, Zamore PD. Plant RNA interference in vitro. Cold Spring Harb Symp Quant Biol. 2004; 69:403-8.
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        82. Tang G, Zamore PD. Biochemical dissection of RNA silencing in plants. Methods Mol Biol. 2004; 257:223-44.
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        83. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003 Oct 17; 115(2):199-208.
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        84. Ding H, Schwarz DS, Keene A, Affar el B, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z. Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell. 2003 Aug; 2(4):209-17.
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        85. Haley B, Tang G, Zamore PD. In vitro analysis of RNA interference in Drosophila melanogaster. Methods. 2003 Aug; 30(4):330-6.
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        86. Zamore PD, Aronin N. siRNAs knock down hepatitis. Nat Med. 2003 Mar; 9(3):266-7.
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        87. Tang G, Reinhart BJ, Bartel DP, Zamore PD. A biochemical framework for RNA silencing in plants. Genes Dev. 2003 Jan 1; 17(1):49-63.
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        88. Schwarz DS, Hutvágner G, Haley B, Zamore PD. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell. 2002 Sep; 10(3):537-48.
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        89. Wang X, McLachlan J, Zamore PD, Hall TM. Modular recognition of RNA by a human pumilio-homology domain. Cell. 2002 Aug 23; 110(4):501-12.
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        90. Hutvágner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science. 2002 Sep 20; 297(5589):2056-60.
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        91. Zamore PD. Ancient pathways programmed by small RNAs. Science. 2002 May 17; 296(5571):1265-9.
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        92. Feldbrügge M, Arizti P, Sullivan ML, Zamore PD, Belasco JG, Green PJ. Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells. Plant Mol Biol. 2002 May; 49(2):215-23.
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        93. Schwarz DS, Zamore PD. Why do miRNAs live in the miRNP? Genes Dev. 2002 May 1; 16(9):1025-31.
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        94. Hutvágner G, Zamore PD. RNAi: nature abhors a double-strand. Curr Opin Genet Dev. 2002 Apr; 12(2):225-32.
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        95. Zamore PD. Thirty-three years later, a glimpse at the ribonuclease III active site. Mol Cell. 2001 Dec; 8(6):1158-60.
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        96. Nykänen A, Haley B, Zamore PD. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell. 2001 Nov 2; 107(3):309-21.
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        97. Zamore PD. RNA interference: listening to the sound of silence. Nat Struct Biol. 2001 Sep; 8(9):746-50.
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        98. Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001 Aug 3; 293(5531):834-8.
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        99. Wang X, Zamore PD, Hall TM. Crystal structure of a Pumilio homology domain. Mol Cell. 2001 Apr; 7(4):855-65.
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        100. Sharp PA, Zamore PD. Molecular biology. RNA interference. Science. 2000 Mar 31; 287(5462):2431-3.
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        101. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000 Mar 31; 101(1):25-33.
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        102. Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev. 1999 Dec 15; 13(24):3191-7.
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        103. Zamore PD, Bartel DP, Lehmann R, Williamson JR. The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence. Biochemistry. 1999 Jan 12; 38(2):596-604.
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        104. Zamore PD, Williamson JR, Lehmann R. The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins. RNA. 1997 Dec; 3(12):1421-33.
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        105. Curtis D, Treiber DK, Tao F, Zamore PD, Williamson JR, Lehmann R. A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J. 1997 Feb 17; 16(4):834-43.
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        106. Zamore PD, Lehmann R. Drosophila development: homeodomains and translational control. Curr Biol. 1996 Jul 1; 6(7):773-5.
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        107. Curtis D, Lehmann R, Zamore PD. Translational regulation in development. Cell. 1995 Apr 21; 81(2):171-8.
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        108. Lee CG, Zamore PD, Green MR, Hurwitz J. RNA annealing activity is intrinsically associated with U2AF. J Biol Chem. 1993 Jun 25; 268(18):13472-8.
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        109. Valcárcel J, Singh R, Zamore PD, Green MR. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature. 1993 Mar 11; 362(6416):171-5.
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        110. Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR. Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8769-73.
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        111. Zamore PD, Patton JG, Green MR. Cloning and domain structure of the mammalian splicing factor U2AF. Nature. 1992 Feb 13; 355(6361):609-14.
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