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    Jennifer Wang MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-8414
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

        Overview 
        Narrative

        Biographical Information

        Academic background

        • A.B., Harvard College, 1991
        • M.D., University of Michigan Medical School, 1995

        Post-graduate training

        • Internal Medicine Residency, Oregon Health Sciences University. 1995 to 1998.
        • Fellowship, Infectious Disease, University of California, San Diego. 1998 to 2002.

        Board certification

        • Diplomate in Internal Medicine, American Board of Internal Medicine, 1998.
        • Diplomate in Infectious Disease, American Board of Internal Medicine, 2001. Recertified 2011.

        Research interests

        My research focuses on how viruses interact with pattern recognition receptors, including Toll-like receptors and RIG-I-like receptors, to activate inflammatory cytokine responses and produce type I interferons. I am currently conducting studies with coxsackie B virus, herpesviruses, and influenza A virus, characterizing their interactions with receptors in different cell types including neutrophils, dendritic cells, and monocytes/macrophages. I am also studying the contribution of enteroviruses to type 1 diabetes.



        Bibliographic 
        selected publications
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        1. de Oliveira RB, Wang JP, Ram S, Gazzinelli RT, Finberg RW, Golenbock DT. Increased Survival in B-Cell-Deficient Mice during Experimental Cerebral Malaria Suggests a Role for Circulating Immune Complexes. MBio. 2014; 5(2).
          View in: PubMed
        2. Foll M, Poh YP, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, Malaspinas AS, Ewing G, Liu P, Wegmann D, Caffrey DR, Zeldovich KB, Bolon DN, Wang JP, Kowalik TF, Schiffer CA, Finberg RW, Jensen JD. Influenza virus drug resistance: a time-sampled population genetics perspective. PLoS Genet. 2014 Feb; 10(2):e1004185.
          View in: PubMed
        3. Mackay CR, Wang JP, Kurt-Jones EA. Dicer's role as an antiviral: still an enigma. Curr Opin Immunol. 2014 Feb; 26C:49-55.
          View in: PubMed
        4. Renzette N, Caffrey DR, Zeldovich KB, Liu P, Gallagher GR, Aiello D, Porter AJ, Kurt-Jones EA, Bolon DN, Poh YP, Jensen JD, Schiffer CA, Kowalik TF, Finberg RW, Wang JP. Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro. J Virol. 2013 Oct 23.
          View in: PubMed
        5. Hendricks GL, Weirich KL, Viswanathan K, Li J, Shriver ZH, Ashour J, Ploegh HL, Kurt-Jones EA, Fygenson DK, Finberg RW, Comolli JC, Wang JP. Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus. J Biol Chem. 2013 Jan 28.
          View in: PubMed
        6. Wang JP, Zhang L, Madera RF, Woda M, Libraty DH. Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants. BMC Immunol. 2012 Jul 6; 13(1):35.
          View in: PubMed
        7. Madera RF, Wang JP, Libraty DH. The combination of early and rapid type I IFN, IL-1a, and IL-1ß production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses. PLoS One. 2011; 6(12):e29412.
          View in: PubMed
        8. Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, Knipe DM, Finberg RW, Kurt-Jones EA. Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol. 2012 Feb; 86(4):2273-81.
          View in: PubMed
        9. Wang JP, Lee CK, Akalin A, Finberg RW, Levitz SM. Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans. PLoS One. 2011; 6(10):e26232.
          View in: PubMed
        10. Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB. LPLUNC1 Modulates Innate Immune Responses to Vibrio cholerae. J Infect Dis. 2011 Nov; 204(9):1349-57.
          View in: PubMed
        11. Ramirez-Ortiz ZG, Lee CK, Wang JP, Boon L, Specht CA, Levitz SM. A Nonredundant Role for Plasmacytoid Dendritic Cells in Host Defense against the Human Fungal Pathogen Aspergillus fumigatus. Cell Host Microbe. 2011 May 19; 9(5):415-24.
          View in: PubMed
        12. Li J, Wang JP, Ghiran I, Cerny A, Szalai AJ, Briles DE, Finberg RW. Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence. Infect Immun. 2010 Jul; 78(7):3129-35.
          View in: PubMed
        13. Wang JP, Cerny A, Asher DR, Kurt-Jones EA, Bronson RT, Finberg RW. MDA5 and MAVS mediate type I interferon responses to coxsackie B virus. J Virol. 2010 Jan; 84(1):254-60.
          View in: PubMed
        14. Huang H, Ostroff GR, Lee CK, Wang JP, Specht CA, Levitz SM. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun. 2009 May; 77(5):1774-81.
          View in: PubMed
        15. Finberg RW, Wang JP. Antiviral responses: different roles for different tolls. Immunity. 2009 Feb 20; 30(2):173-5.
          View in: PubMed
        16. Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ. The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009 Jan; 5(1):e1000277.
          View in: PubMed
        17. Wang JP, Bowen GN, Padden C, Cerny A, Finberg RW, Newburger PE, Kurt-Jones EA. Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood. 2008 Sep 1; 112(5):2028-34.
          View in: PubMed
        18. Dan JM, Wang JP, Lee CK, Levitz SM. Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides. PLoS One. 2008; 3(4):e2046.
          View in: PubMed
        19. Ramirez-Ortiz ZG, Specht CA, Wang JP, Lee CK, Bartholomeu DC, Gazzinelli RT, Levitz SM. Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect Immun. 2008 May; 76(5):2123-9.
          View in: PubMed
        20. Wang JP, Kurt-Jones EA, Finberg RW. Innate immunity to respiratory viruses. Cell Microbiol. 2007 Jul; 9(7):1641-6.
          View in: PubMed
        21. Zhou S, Kurt-Jones EA, Fitzgerald KA, Wang JP, Cerny AM, Chan M, Finberg RW. Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection. J Immunol. 2007 Apr 15; 178(8):5173-81.
          View in: PubMed
        22. Wang JP, Asher DR, Chan M, Kurt-Jones EA, Finberg RW. Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA. J Immunol. 2007 Mar 15; 178(6):3363-7.
          View in: PubMed
        23. Finberg RW, Wang JP, Kurt-Jones EA. Toll like receptors and viruses. Rev Med Virol. 2007 Jan-Feb; 17(1):35-43.
          View in: PubMed
        24. Wang JP, Liu P, Latz E, Golenbock DT, Finberg RW, Libraty DH. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J Immunol. 2006 Nov 15; 177(10):7114-21.
          View in: PubMed
        25. Wang JP, Kurt-Jones EA, Shin OS, Manchak MD, Levin MJ, Finberg RW. Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol. 2005 Oct; 79(20):12658-66.
          View in: PubMed
        26. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 1; 45(2):303-10.
          View in: PubMed
        27. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, Chan M, Knipe DM, Finberg RW. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005 Mar 1; 191(5):746-8.
          View in: PubMed
        28. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1315-20.
          View in: PubMed
        29. Wang JP, Rought SE, Corbeil J, Guiney DG. Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection. FEMS Immunol Med Microbiol. 2003 Nov 28; 39(2):163-72.
          View in: PubMed
        30. Wang JP, Granlund KF, Bozzette SA, Botte MJ, Fierer J. Bursal sporotrichosis: case report and review. Clin Infect Dis. 2000 Aug; 31(2):615-6.
          View in: PubMed
        31. Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL, et al. Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. Diabetes. 1995 Jan; 44(1):90-7.
          View in: PubMed
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