Diabetes Mellitus, Type 1

"Diabetes Mellitus, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Descriptor ID	D003922
MeSH Number(s)	C18.452.394.750.124 C19.246.267 C20.111.327
Concept/Terms	Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus, Brittle Brittle Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Insulin Dependent Insulin-Dependent Diabetes Mellitus Diabetes Mellitus, Juvenile-Onset Diabetes Mellitus, Juvenile Onset Juvenile-Onset Diabetes Mellitus Diabetes Mellitus, Ketosis-Prone Diabetes Mellitus, Ketosis Prone Ketosis-Prone Diabetes Mellitus Juvenile-Onset Diabetes Diabetes, Juvenile-Onset Juvenile Onset Diabetes Diabetes Mellitus, Type I Diabetes Mellitus, Sudden-Onset Diabetes Mellitus, Sudden Onset Mellitus, Sudden-Onset Diabetes Sudden-Onset Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent, 1 Insulin-Dependent Diabetes Mellitus 1 Insulin Dependent Diabetes Mellitus 1 Type 1 Diabetes Diabetes, Type 1 IDDM Diabetes, Autoimmune Diabetes, Autoimmune Autoimmune Diabetes

Below are MeSH descriptors whose meaning is more general than "Diabetes Mellitus, Type 1".

Diseases [C]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Glucose Metabolism Disorders [C18.452.394]
Diabetes Mellitus [C18.452.394.750]
Diabetes Mellitus, Type 1 [C18.452.394.750.124]
Endocrine System Diseases [C19]
Diabetes Mellitus [C19.246]
Diabetes Mellitus, Type 1 [C19.246.267]
Immune System Diseases [C20]
Autoimmune Diseases [C20.111]
Diabetes Mellitus, Type 1 [C20.111.327]

Below are MeSH descriptors whose meaning is related to "Diabetes Mellitus, Type 1".

Below are MeSH descriptors whose meaning is more specific than "Diabetes Mellitus, Type 1".

Diabetes Mellitus, Type 1
Wolfram Syndrome

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Diabetes Mellitus, Type 1" by people in this website by year, and whether "Diabetes Mellitus, Type 1" was a major or minor topic of these publications.

Bar chart showing 404 publications over 31 distinct years, with a maximum of 26 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	9	0	9
1997	4	1	5
1998	5	0	5
1999	7	1	8
2000	3	0	3
2001	10	0	10
2002	14	1	15
2003	21	0	21
2004	20	1	21
2005	14	1	15
2006	16	1	17
2007	16	1	17
2008	8	1	9
2009	23	3	26
2010	17	2	19
2011	15	2	17
2012	9	3	12
2013	10	0	10
2014	12	1	13
2015	10	2	12
2016	19	3	22
2017	14	3	17
2018	13	1	14
2019	12	1	13
2020	15	0	15
2021	12	1	13
2022	10	0	10
2023	12	0	12
2024	5	3	8
2025	9	2	11
2026	5	0	5

Below are the most recent publications written about "Diabetes Mellitus, Type 1" by people in Profiles.

Dwyer JR, Racine JJ, Chapman HD, Bell A, Quinlan A, Stafford GA, Serreze DV. Multiple Mechanisms Contribute to Robust Type 1 Diabetes Protection in Nfkbid- Overexpressing NOD Mice. Diabetes. 2026 05 01; 75(5):816-824.

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Syed F, Krishnan P, Chang G, Rana J, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Del Carmen Aquino J, Hagedorn E, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C. Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. 2026 Jul; 69(7):1975-1996.

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Amdare N, Ali R, Manganaro A, Baker JC, Antal Z, Smith C, Santamaria P, Kent SC, DiLorenzo TP. Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04. J Immunol. 2026 02 09; 215(2).

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Aydemir O, Bailey JA, Agardh D, Lernmark ?, Noble JA, Andersson Sv?rd A, Blankenhorn EP, Parikh HM, Ziegler AG, Toppari J, Akolkar B, Hagopian WA, Rewers MJ, Mordes JP. Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B. Elife. 2026 Feb 02; 12.

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Soloperto C, Aronowitz T. Beyond the Clinic: Supporting Type 1 Diabetes-A Case Study Highlighting Collaboration Between an APRN and School Nurse. NASN Sch Nurse. 2026 01; 41(1):34-38.

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Racine JJ, Dwyer JR, Chapman HD, Bell A, Robledo RF, Serreze DV. Direct-in-NOD genetic ablation of Bcl3 leads to complete type 1 diabetes protection. J Immunol. 2025 Nov 01; 214(11):2847-2860.

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Armentrout BL, Wenzell ML, Strohl KP, Crawford SL, Wood JR, Li CR, Hickman RL, Griggs SA. A randomized pilot sleep and circadian behavior clinical trial to improve glycemic and psychological outcomes in young adults with type 1 diabetes (NCT04975230). Diabetes Metab Syndr. 2025 Sep; 19(9):103305.

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Lee S, Carlberg VM, Todd P, Schmidt BAR, Garza-Mayers AC, Ho T. Continuous Subcutaneous Insulin Infusion (CSII)-Associated Granulomatous Suppurative Reaction in?Four Children With Type 1 Diabetes. Pediatr Dermatol. 2026 Mar-Apr; 43(2):415-420.

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Serreze DV, Tousey-Pfarrer M, Racine JJ. Humanized Mouse Models for Type 1 Diabetes. Curr Protoc. 2025 Oct; 5(10):e70224.

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Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ. The antigen presentation landscape of cytokine-stressed human pancreatic islets. Cell Rep. 2025 Aug 26; 44(8):115927.

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