Insulin-Secreting Cells

"Insulin-Secreting Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.

Descriptor ID	D050417
MeSH Number(s)	A03.734.414.131 A06.390.131 A06.407.414.087 A11.382.625.092 A11.436.294.092
Concept/Terms	Insulin-Secreting Cells Insulin-Secreting Cells Cell, Insulin-Secreting Cells, Insulin-Secreting Insulin Secreting Cells Insulin-Secreting Cell beta Cells, Pancreatic Pancreatic beta Cell beta Cell, Pancreatic Pancreatic B Cells B Cell, Pancreatic B Cells, Pancreatic Pancreatic B Cell Pancreatic beta Cells

Below are MeSH descriptors whose meaning is more general than "Insulin-Secreting Cells".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Insulin-Secreting Cells [A03.734.414.131]
Endocrine System [A06]
Enteroendocrine Cells [A06.390]
Insulin-Secreting Cells [A06.390.131]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]
Insulin-Secreting Cells [A06.407.414.087]
Cells [A11]
Endocrine Cells [A11.382]
Enteroendocrine Cells [A11.382.625]
Insulin-Secreting Cells [A11.382.625.092]
Epithelial Cells [A11.436]
Enteroendocrine Cells [A11.436.294]
Insulin-Secreting Cells [A11.436.294.092]

Below are MeSH descriptors whose meaning is related to "Insulin-Secreting Cells".

Below are MeSH descriptors whose meaning is more specific than "Insulin-Secreting Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulin-Secreting Cells" by people in this website by year, and whether "Insulin-Secreting Cells" was a major or minor topic of these publications.

Bar chart showing 118 publications over 21 distinct years, with a maximum of 12 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	3	0	3
2007	2	1	3
2008	3	1	4
2009	7	4	11
2010	10	2	12
2011	3	4	7
2012	6	1	7
2013	2	0	2
2014	7	1	8
2015	7	1	8
2016	8	0	8
2017	6	2	8
2018	6	5	11
2019	3	2	5
2020	4	4	8
2021	2	3	5
2022	1	0	1
2023	1	0	1
2024	3	1	4
2025	1	0	1

Below are the most recent publications written about "Insulin-Secreting Cells" by people in Profiles.

Carr? A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, G?ransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Interferon-a promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic ?-cells. Nat Commun. 2025 Jan 17; 16(1):765.

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Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Mol Metab. 2024 Dec; 90:102050.

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Fu A. Reconsidering lactate disallowance in pancreatic ? cells. Trends Endocrinol Metab. 2024 Dec; 35(12):1023-1025.

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Singh A, Abhilasha KV, Acharya KR, Liu H, Nirala NK, Parthibane V, Kunduri G, Abimannan T, Tantalla J, Zhu LJ, Acharya JK, Acharya UR. A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila. Nat Commun. 2024 May 23; 15(1):4410.

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Vecchio F, Carr? A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S, You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Coxsackievirus infection induces direct pancreatic ? cell killing but poor antiviral CD8+ T cell responses. Sci Adv. 2024 Mar 08; 10(10):eadl1122.

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James EA, Joglekar AV, Linnemann AK, Russ HA, Kent SC. The beta cell-immune cell interface in type 1 diabetes (T1D). Mol Metab. 2023 Dec; 78:101809.

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Skovs? S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-M?neur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nat Commun. 2022 02 08; 13(1):735.

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Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ. Modeling human T1D-associated autoimmune processes. Mol Metab. 2022 02; 56:101417.

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Sharma RB, Landa-Galv?n HV, Alonso LC. Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic ?-Cells. Diabetes. 2021 11; 70(11):2431-2443.

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Homan EP, Brand?o BB, Softic S, El Ouaamari A, O'Neill BT, Kulkarni RN, Kim JK, Kahn CR. Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue. J Clin Invest. 2021 10 01; 131(19).

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