Islets of Langerhans

"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Descriptor ID	D007515
MeSH Number(s)	A03.734.414 A06.407.414
Concept/Terms	Islets of Langerhans Islets of Langerhans Langerhans Islets Pancreatic Islets Islet, Pancreatic Islets, Pancreatic Pancreatic Islet Nesidioblasts Nesidioblast Pancreas, Endocrine Endocrine Pancreas Islands of Langerhans Langerhans Islands Islet Cells Cell, Islet Cells, Islet Islet Cell

Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Endocrine System [A06]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]

Below are MeSH descriptors whose meaning is related to "Islets of Langerhans".

Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.

Bar chart showing 167 publications over 30 distinct years, with a maximum of 13 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	1	3
1998	0	1	1
1999	0	1	1
2000	2	2	4
2001	2	1	3
2002	8	4	12
2003	7	5	12
2004	3	8	11
2005	7	6	13
2006	5	3	8
2007	3	3	6
2008	7	1	8
2009	5	2	7
2010	1	1	2
2011	2	1	3
2012	3	3	6
2013	1	2	3
2014	3	2	5
2015	4	3	7
2016	6	0	6
2017	1	4	5
2018	4	2	6
2019	3	2	5
2020	0	7	7
2021	2	2	4
2022	1	0	1
2023	4	0	4
2024	2	2	4
2025	3	1	4
2026	4	2	6

Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.

Press C, D'Amour K, Mamrak N, Pepperl D, Kutner RH, Colleluori DM, Graham ML, Brehm MA, Hussain N, Latres E, Marinac M. Allogeneic islet products for type 1 diabetes: Navigating nonclinical and manufacturing regulatory expectations. Stem Cell Reports. 2026 Jul 14; 21(7):102998.

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Saunders DC, Feng F, Hopkirk AL, Aamodt KI, Hart N, Pan FC, Reihsmann CV, Izmaylov N, Mei S, Sherrod BA, Davis C, Nonpanya N, Pettway YD, Patel KP, Lee KS, Duryea J, Haliyur R, Aramandla R, Durai H, Poffenberger G, Martin A, Posgai AL, Kusmartseva I, Beery ML, Yang M, Xu K, Kang H, Greiner DL, Shultz LD, Cartailler JP, Bottino R, Atkinson MA, Wright CVE, Powers AC, Brissova M. Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods. Nat Commun. 2026 06 29; 17(1).

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Dwyer JR, Racine JJ, Chapman HD, Bell A, Quinlan A, Stafford GA, Serreze DV. Multiple Mechanisms Contribute to Robust Type 1 Diabetes Protection in Nfkbid- Overexpressing NOD Mice. Diabetes. 2026 May 01; 75(5):816-824.

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Syed F, Krishnan P, Chang G, Rana J, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Del Carmen Aquino J, Hagedorn E, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C. Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. 2026 Jul; 69(7):1975-1996.

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Amdare N, Ali R, Manganaro A, Baker JC, Antal Z, Smith C, Santamaria P, Kent SC, DiLorenzo TP. Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04. J Immunol. 2026 Feb 09; 215(2).

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Yokoi N, Shigenaka S, Nakata C, Takagi M, Xiao Y, Hirokoji T, Sasase T, Uno K, Ohta T. Effects of sex hormones on the development of diabetes and pancreatic islet gene expression in obese type 2 diabetes model ZFDM rat. Exp Anim. 2026 Jul 01; 75(3):262-276.

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Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ. The antigen presentation landscape of cytokine-stressed human pancreatic islets. Cell Rep. 2025 Aug 26; 44(8):115927.

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Parent AV, Agarwal A, Alvarez-Dominguez JR, Arrojo E Drigo R, Atkinson MA, Brehm MA, Ferreira LMR, Kaestner KH, Kravets V, Niland JC, O'Meally D, Rouse L, Russ HA, Stabler CL, Kaddis JS. Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative. Diabetes. 2025 Jul 01; 74(7):1057-1067.

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Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia. 2025 Aug; 68(8):1721-1734.

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Arowosegbe A, Guo Z, Vanderleeden E, Derr AG, Wang JP. Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats. J Autoimmun. 2025 Feb; 151:103358.

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