Disease Models, Animal

"Disease Models, Animal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Descriptor ID	D004195
MeSH Number(s)	C22.232 E05.598.500 E05.599.395.080
Concept/Terms	Disease Models, Animal Disease Models, Animal Animal Disease Model Animal Disease Models Disease Model, Animal

Below are MeSH descriptors whose meaning is more general than "Disease Models, Animal".

Diseases [C]
Animal Diseases [C22]
Disease Models, Animal [C22.232]
Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Models, Animal [E05.598]
Disease Models, Animal [E05.598.500]
Models, Theoretical [E05.599]
Models, Biological [E05.599.395]
Disease Models, Animal [E05.599.395.080]

Below are MeSH descriptors whose meaning is related to "Disease Models, Animal".

Below are MeSH descriptors whose meaning is more specific than "Disease Models, Animal".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Disease Models, Animal" by people in this website by year, and whether "Disease Models, Animal" was a major or minor topic of these publications.

Bar chart showing 1534 publications over 30 distinct years, with a maximum of 106 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	0	5	5
1998	0	3	3
1999	0	5	5
2000	2	9	11
2001	5	14	19
2002	3	28	31
2003	2	34	36
2004	7	41	48
2005	7	41	48
2006	5	47	52
2007	5	55	60
2008	9	48	57
2009	11	52	63
2010	14	44	58
2011	13	60	73
2012	9	49	58
2013	6	59	65
2014	11	76	87
2015	10	65	75
2016	7	99	106
2017	7	76	83
2018	6	92	98
2019	7	73	80
2020	9	76	85
2021	5	59	64
2022	0	30	30
2023	0	19	19
2024	18	39	57
2025	4	51	55

Below are the most recent publications written about "Disease Models, Animal" by people in Profiles.

Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice. Aging Cell. 2025 Nov; 24(11):e70148.

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Krunic A, Bellio TA, Cohen BZ, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Brain DNA Methylation Atlas of AppNL-G-F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline-Induced Resilience. Aging Cell. 2025 Nov; 24(11):e70241.

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Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. Mol Ther. 2025 Dec 03; 33(12):6379-6397.

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Cashman TJ, Saheera S, Blau AE, Mensah Otabil E, Nagy NY, Samenuk TD, Fitzgibbons TP, McManus DD, Trivedi CM. Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. JCI Insight. 2025 Sep 09; 10(17).

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Matsuoka Y, Katsumata Y, Chu PS, Morikawa R, Nakamoto N, Iguchi K, Takahashi K, Kou T, Ito R, Taura K, Yazumi S, Terajima H, Honjo G, Ichihara G, Muramoto Y, Sato K, Maeda R, Hata K, Toriu N, Yanagita M, Tajima M, Fagarasan S, Yamada KI, Sugiura Y. Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers. Redox Biol. 2025 Oct; 86:103858.

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Cardoso KF, de Souza LRA, Martins DS, da Silva Santos BS?, de Carvalho KRA, da Silva Messias SG, de Faria Gon?alves AP, Do Nascimento Mac?rio RR, de Jesus DJF, De Mendon?a ?ngelo ALP, de Paula Pereira L, Nascimento SLM, Kano FS, Alves PA, Xavier MAP, Martins-Filho OA, Russo RC, Gazzinelli RT, Miyaji EN, Garcia CC, de Magalh?es Vieira Machado A, Ara?jo MSS. Safety and efficacy of an intramuscular bivalent vaccine against influenza and Streptococcus pneumoniae infections in mice. Med Microbiol Immunol. 2025 Aug 29; 214(1):39.

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Bamidele N, Pires-Ferreira D, Zheng C, Destefano A, Cheng H, Tang Q, Cao Y, Xie J, Gao G, Gruntman A, Sontheimer E, Flotte TR, Xue W. A compact base editor rescues AATD-associated liver and lung disease in mouse models. Mol Ther. 2025 Nov 05; 33(11):5817-5828.

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Acharya S, Riley D, Dayoub A, Acharya E, Rebentisch A, Simmons M, Bowen S, Beachy J, Dawson E, Major E, Borton M, Van Boerum J, Dahl MJ, Bhandari V, Kallapur SG, Christensen DJ, Albertine KH. Pulmonary and neurobehavioral efficacies of AVR-48, a TLR4 modulator, in a preterm lamb model of bronchopulmonary dysplasia. Respir Res. 2025 Aug 25; 26(1):261.

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Gorasiya S, Mushi J, Yoganathan S, Barasa L, Pekson R, Ashby CR, Reznik SE. N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth. Sci Rep. 2025 Aug 14; 15(1):29861.

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Samarasinghe AE, Randell SH, Kulkarni HS, Weiser JN, Quinton LJ, Dickson RP, Mizgerd JP, Orihuela CJ, Parker D, Robinson KM, Prince AS, Evans SE, Kolls JK, Lee JS, Jeyaseelan S, Torres A, Miller LA, Hamilton DJ, G?mez MI, Moore BB, Walker RL, Barkal LJ, Hook JL, Lau GW, Sharma J, Witzenrath M, Dela Cruz CS. Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2025 Aug; 73(2):178-199.

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