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    Last Name

    Jie Song PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentOrthopedics and Physical Rehabilitation
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - School of Medicine
      DepartmentOrthopedics and Physical Rehabilitation

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentChemical Biology

        awards and honors
        University of Massachusetts2016OTCV Technology Development Fund Award
        University of Massachusetts2015OTCV Technology Development Fund Award
        UMASS Medical School2015Faculty Vitality Award
        Musculoskeletal Transplant Foundation2015J.R. Neff Award
        Worcester Foundation/Hudson Hoagland Society 2014Mel and Sandy Cutler Award
        GSBS/UMMS2013Dean’s Award for Research Mentoring and Commitment to Student Professional Advancement
        University of Massachusetts 2013Commercial Ventures & Intellectual Property Award
        University of Massachusetts 2011Commercial Ventures & Intellectual Property Award
        National Institutes of Health2008Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award
        American Society for Bone and Mineral Research 2008Career Enhancement Award
        University of Massachusetts 2007Commercial Ventures & Intellectual Property Award
        Massachusetts Technology Transfer Center2007Technology Investigation Award
        American Society for Bone and Mineral Research 2007Harold M. Frost Young Investigator Award


        B.S. 1995, Fudan University, P.R. China
        Ph.D. 1999, Michigan State University
        Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
        Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

        Research Interests

        With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, cancer and metabolic diseases is rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment and stable fixation), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.

        Additional Info on Dr. Song

        Representative Publications

        Lab Members

        Rotation Projects

        Potential Rotation Projects

        1. Design and evaluation of smart synthetic bone / cartilage tissue grafts
        2. Metallic implant surface modifications for reducing periprosthetic infections
        3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis

        Post Docs

        Postdoc openings are avaialble for funded projects aimed at developing more effective strategies towards the prevention of periprosthetic infections or scaffold-mediated cartilage and bone regenerations. 

        A recent Ph.D. (within the last 2 years) in chemistry, materials sciences, bioengineering, or biology is required. Hands-on experience in polymer synthesis, structural and mechanical characterizations of composite materials, and/or cell and molecular biology techniques are desired. For examples of our recent work in the development of functional synthetic scaffolds for regenerative medicine applications, please refer to the "Selected Publications" section.

        Interested candidate should email a copy of CV including a list of publications, names of 3 referees and a brief statement of research interest (1-2 pages) to Dr. Song:


        Paid Undergraduate Interns:

        A paid undergraduate intern position is available for Sophomore or Junior student from the Worcester area colleges who is motivated to pursue a research career and seeks to gain hands-on wet lab experience. Student with prior organic chemistry lab exposure is preferred. Candidate should be able to commit no less than 12-15h/week (Mon-Fri) during regular semesters, and work full time during the summer. To apply, email a copy of resume (with your GPA and major lab courses taken indicated) to Dr. Song:

        selected publications
        List All   |   Timeline
        1. Ben Zhang, Janae DeBartolo and Jie Song. Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water. ACS Appl. Mater. Interface. 2017; Accepted.
        2. Henry Huang, Jordan Skelly, David C. Ayers, Jie Song. Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus. Scientific Reports. 2017; In press.
        3. Ben Zhang, Tera M. Filion, Artem B. Kutikov and Jie Song. Facile Stem Cell Delivery to Bone Grafts Enabled by Smart Shape Recovery and Stiffening of Degradable Synthetic Periosteal Membranes. Adv. Funct. Mater. 2017; 1604784.
        4. Huang H, Veien ES, Zhang H, Ayers DC, Song J. Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes. PLoS One. 2016; 11(1):e0148088.
          View in: PubMed
        5. Pingsheng Liu, Jie Song. Well-controlled ATRP of 2-(2-(2-Azidoethyoxy)ethoxy)ethyl Methacrylate for High-density Click Functionalization of Polymers and Metallic Substrates. J. Polym. Sci. A Polym. Chem. 2016; 54:1268-1277.
        6. Youssefian S, Liu P, Askarinejad S, Shalchy F, Song J, Rahbar N. Experimental and numerical measurements of adhesion energies between PHEMA and PGLYMA with hydroxyapatite crystal. Bioinspir Biomim. 2015 Aug; 10(4):046011.
          View in: PubMed
        7. Artem Kutikov and Jie Song. Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications. ACS Biomater. Sci. Eng. 2015; 10.1021/acsbiomaterials.5b0012.
        8. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 4; 7(8):4890-901.
          View in: PubMed
        9. Liu P, Emmons E, Song J. A comparative study of zwitterionic ligands-mediated mineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering. J Mater Chem B Mater Biol Med. 2014 Nov 21; 2(43):7524-7533.
          View in: PubMed
        10. Kutikov AB, Reyer KA, Song J. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol Chem Phys. 2014 Dec; 215(24):2482-2490.
          View in: PubMed
        11. Kutikov AB, Gurijala A, Song J. Rapid prototyping amphiphilic polymer/hydroxyapatite composite scaffolds with hydration-induced self-fixation behavior. Tissue Eng Part C Methods. 2015 Mar; 21(3):229-41.
          View in: PubMed
        12. Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23.
          View in: PubMed
        13. Liu P, Skelly JD, Song J. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014 Oct; 10(10):4296-303.
          View in: PubMed
        14. Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52.
          View in: PubMed
        15. Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90.
          View in: PubMed
        16. Xu J, Feng E, Song J. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci. 2014 Mar 5; 131(5).
          View in: PubMed
        17. Xu J, Feng E, Song J. Bioorthogonally cross-linked hydrogel network with precisely controlled disintegration time over a broad range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8.
          View in: PubMed
        18. Filion TM, Song J. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomater Tissue Eng. 2013 Aug 1; 3(4):486-493.
          View in: PubMed
        19. Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7.
          View in: PubMed
        20. Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep; 9(9):8354-64.
          View in: PubMed
        21. Zhao L, Kutikov A, Shen J, Duan C, Song J, Han G. Stem cell labeling using polyethylenimine conjugated (a-NaYbF4:Tm3+)/CaF2 upconversion nanoparticles. Theranostics. 2013; 3(4):249-57.
          View in: PubMed
        22. Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54.
          View in: PubMed
        23. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7.
          View in: PubMed
        24. Jianwen Xu and Jie Song. Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications, Chapter 11. Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed.Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed. 2012.
        25. Xu J, Filion TM, Prifti F, Song J. Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. Chem Asian J. 2011 Oct 4; 6(10):2730-7.
          View in: PubMed
        26. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95.
          View in: PubMed
        27. Xu J, Prifti F, Song J. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules. 2011 Apr 26; 44(8):2660-2667.
          View in: PubMed
        28. Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5067-70.
          View in: PubMed
        29. Chung WJ, Kwon KY, Song J, Lee SW. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir. 2011 Jun 21; 27(12):7620-8.
          View in: PubMed
        30. Jianwen Xu and Jie Song. Thermal responsive shape memory polymers for biomedical applications, Chapter 6. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 125-142.
        31. Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248.
        32. Filion TM, Xu J, Prasad ML, Song J. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials. 2011 Feb; 32(4):985-91.
          View in: PubMed
        33. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11.
          View in: PubMed
        34. Xu J, Song J. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7652-7.
          View in: PubMed
        35. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11.
          View in: PubMed
        36. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107.
          View in: PubMed
        37. Su J, Iomdina E, Tarutta E, Ward B, Song J, Wildsoet CF. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. Exp Eye Res. 2009 Mar; 88(3):445-57.
          View in: PubMed
        38. Song J. A chemical and engineering approach towards "smart" synthetic bone grafts. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):325.
          View in: PubMed
        39. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23.
          View in: PubMed
        40. Song J, Malathong V, Bertozzi CR. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72.
          View in: PubMed
        41. Jie Song and Carolyn R. Bertozzi. Functional polymers for bone tissue engineering applications. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed. 2005; 2:371-392.
        42. Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005; 7(11):999-1004.
        43. Jie Song and , Carolyn R. Bertozzi. Functional Hydrogel-Biomineral Composites Inspired by Natural Bone, Chapter 7. Polymer Biocatalysis and Biomaterials. 2005; 900:96-106.
        44. Song J, Cisar JS, Bertozzi CR. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65.
          View in: PubMed
        45. Cheng Q, Zhu S, Song J, Zhang N. Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin. Analyst. 2004 Apr; 129(4):309-14.
          View in: PubMed
        46. Jie Song, Raymond C. Stevens and Quan Cheng. Functional Amphiphilic and Bolaamphiphilic Poly(diacetylene) Assemblies with Controlled Optical and Morphological Properties, Chapter 7. Chromogenic Phenomena in Polymers. 2004; 888:96-109.
        47. Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands. J. Mater. Chem. 2004; 14:2643-2648.
        48. Song J, Saiz E, Bertozzi CR. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 5; 125(5):1236-43.
          View in: PubMed
        49. Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003; 23(15):2905-2919.
        50. Jie Song, Quan Cheng and Raymond C. Stevens. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem. Phys. Lipids. 2002; 114:203-214.
        51. Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices. 2002; 4(3):213-221.
        52. Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. J Am Chem Soc. 2001 Apr 11; 123(14):3205-13.
          View in: PubMed
        53. Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry. 2001; 12:387-391.
        54. Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999; 121:1851-1861.
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