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    Last Name

    Jie Song PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentOrthopedics and Physical Rehabilitation
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentChemical Biology



        B.S. 1995, Fudan University, P.R. China
        Ph.D. 1999, Michigan State University
        Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
        Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

        Research Interests

        With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, cancer and metabolic diseases is rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment and stable fixation), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.

        Additional Info on Dr. Song

        Representative Publications

        Lab Members

        Rotation Projects

        Potential Rotation Projects

        1. Design and evaluation of smart synthetic bone / cartilage tissue grafts
        2. Metallic implant surface modifications for reducing periprosthetic infections
        3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis

        Post Docs

        A postdoc position in biomaterials-guided skeletal tissue repair/regeneration is available. Hands-on experience in functional monomer synthesis and controlled polymerization techniques as well as standard small molecule and polymeric material characterizations (NMR, MS, GPC, DSC, mechanical testing) are required. Experience with various materials fabrication/processing techniques (3-D printing, electrospinning, etc.), cell culture and/or smal animal studies are preferred. For examples of our recent work in the development of functional degradable polymers and hydrogels, shape memory polymers, metallic surface modificaitons for regenerative medicine applications, please refer to the "Selected Publications" section. Interested candidate should email a copy of CV including a full list of publications, names of 3 referees and a brief statement of research interest (no more than 2 pages) to Dr. Song:

        selected publications
        List All   |   Timeline
        1. Artem B. Kutikov, Jordan D. Skelly, David C. Ayers, and Jie Song. Templated Repair of Long Bone Defects in Rats with Bioactive Spiral-Wrapped Electrospun Amphiphilic Polymer/Hydroxyapatite Scaffolds. ACS Applied Materials & Interfaces. 2015; In press.
        2. Pingsheng Liu, Erin Emmons and Jie Song. A comparative study of zwitterionic ligands-mediated biomineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering. J. Mater. Chem. B. 2014; 2(43):7524-7533.
        3. Artem Kutikov, Kevin A. Reyer and Jie Song. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol. Chem. Phys. 2014; In press.
        4. Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers and Jie Song. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin. Orthop. Relat. Res. 2014; 472:4015–4023 .
        5. Artem B. Kutikov, Anvesh Gurijala and Jie Song. A rapid prototyped amphiphilic polymer/hydroxyapatite composite scaffold with hydration-induced self-fixation behavior. Tissue Eng. Part B: Methods. 2014; DOI: 10.1089/ten.tec.2014.0213.
        6. Pingsheng Liu, Jordan D. Skelly and Jie Song. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014; 10(10):4296–4303.
        7. Pingsheng Liu, Emily Domingue, David C. Ayers and Jie Song. Modification of Ti6Al4V Substrates with Well-defined Zwitterionic Polysulfobetaine Brushes for Improved Surface Mineralization. ACS Appl. Mater. Interfaces. 2014; doi 10.1021/am501967y.
        8. Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90.
          View in: PubMed
        9. Xu J, Feng E, Song J. Bioorthogonally cross-linked hydrogel network with precisely controlled disintegration time over a broad range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8.
          View in: PubMed
        10. Jianwen Xu, Ellva Feng and Jie Song. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci (Journal cover article). 2014; 131:39822.
        11. Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep; 9(9):8354-64.
          View in: PubMed
        12. Tera Filion and Jie Song. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomat Tissue Eng. 2013; 3(4):486-493.
        13. Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54.
          View in: PubMed
        14. Liang Zhao*, Artem Kutikov*, Jie Shen, Chunying Duan, Jie Song and Gang Han (*co-first author). Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranotics (Journal cover article). 2013; 4(3):249-257.
        15. Xinning Li, Jianwen Xu, Tera M. Filion, David C. Ayers and Jie Song. pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute. Clin. Orthop. Relat. Res. 2013; 471(8):2540-2547.
        16. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7.
          View in: PubMed
        17. Jianwen Xu and Jie Song. Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications, Chapter 11. Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed.Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed. 2012.
        18. Xu J, Filion TM, Prifti F, Song J. Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry. Chem Asian J. (Frontispiece article). 2011; 10(6):2730-2737.
        19. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95.
          View in: PubMed
        20. Xu J, Prifti F, Song J. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules. 2011 Apr 26; 44(8):2660-2667.
          View in: PubMed
        21. Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5067-70.
          View in: PubMed
        22. Chung WJ, Kwon KY, Song J, Lee SW. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir. 2011 Jun 21; 27(12):7620-8.
          View in: PubMed
        23. Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248.
        24. Jianwen Xu and Jie Song. Thermal responsive shape memory polymers for biomedical applications, Chapter 6. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 125-142.
        25. Filion TM, Xu J, Prasad ML, Song J. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials. 2011 Feb; 32(4):985-91.
          View in: PubMed
        26. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11.
          View in: PubMed
        27. Xu J, Song J. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7652-7.
          View in: PubMed
        28. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11.
          View in: PubMed
        29. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107.
          View in: PubMed
        30. Su J, Iomdina E, Tarutta E, Ward B, Song J, Wildsoet CF. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. Exp Eye Res. 2009 Mar; 88(3):445-57.
          View in: PubMed
        31. Song J. A chemical and engineering approach towards "smart" synthetic bone grafts. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):325.
          View in: PubMed
        32. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23.
          View in: PubMed
        33. Song J, Malathong V, Bertozzi CR. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72.
          View in: PubMed
        34. Jie Song and Carolyn R. Bertozzi. Functional polymers for bone tissue engineering applications. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed. 2005; 2:371-392.
        35. Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005; 7(11):999-1004.
        36. Jie Song and , Carolyn R. Bertozzi. Functional Hydrogel-Biomineral Composites Inspired by Natural Bone, Chapter 7. Polymer Biocatalysis and Biomaterials. 2005; 900:96-106.
        37. Song J, Cisar JS, Bertozzi CR. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65.
          View in: PubMed
        38. Cheng Q, Zhu S, Song J, Zhang N. Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin. Analyst. 2004 Apr; 129(4):309-14.
          View in: PubMed
        39. Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands. J. Mater. Chem. 2004; 14:2643-2648.
        40. Jie Song, Raymond C. Stevens and Quan Cheng. Functional Amphiphilic and Bolaamphiphilic Poly(diacetylene) Assemblies with Controlled Optical and Morphological Properties, Chapter 7. Chromogenic Phenomena in Polymers. 2004; 888:96-109.
        41. Song J, Saiz E, Bertozzi CR. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 5; 125(5):1236-43.
          View in: PubMed
        42. Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003; 23(15):2905-2919.
        43. Jie Song, Quan Cheng and Raymond C. Stevens. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem. Phys. Lipids. 2002; 114:203-214.
        44. Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices. 2002; 4(3):213-221.
        45. Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. J Am Chem Soc. 2001 Apr 11; 123(14):3205-13.
          View in: PubMed
        46. Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry. 2001; 12:387-391.
        47. Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999; 121:1851-1861.
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