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    Jie Song PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentOrthopedics and Physical Rehabilitation
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-7168
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentChemical Biology

        Overview 
        Narrative

        Biography

        B.S. 1995, Fudan University, P.R. China
        Ph.D. 1999, Michigan State University
        Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
        Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

        Research Interests

        Synthetic tissue grafts and smart implants guiding the repair and regeneration of musculoskeletal tissues

        With a growing and aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, aging, cancer and metabolic diseases is quickly rising. Our lab is interested in designing synthetic tissue scaffolds and next-generation orthopedic implants that recapitulate key functional features of the extracellular matrices of skeletal tissues to expedite the repair or guide the regeneration of musculoskeletal tissues. These synthetic constructs are also programmed with unique physical properties to facilitate surgical handling (e.g. deployable, elastic, injectable) and proper in vivo degradation. Specific research directions include:

         

        • Development of 2-dimensional and 3-dimensional bioactive synthetic tissue scaffolds directing the lineage commitment of mesenchymal stem cells for the reconstruction of musculoskeletal defects via minimally invasive surgical procedures;
        • Development of new methods for spatially controlled presentation and temporally controlled release of growth factors and cytokines on and from synthetic tissue grafts;
        • Identification of novel factors regulating the self-renewal of mesenchymal stem cells and the regenerative capacities of skeletal tissues;
        • Nanoparticles for skeletal tissue imaging and in vivo tracking of stem cells.

         

         

        Song_Lab_research

        Link to Jie Song's research page

        Lab Members

        Song Lab August 2014



        Rotation Projects

        Potential Rotation Projects

        1. Design and evaluation of the in vitro and in vivo performance of synthetic bone / cartilage tissue grafts
        2. Novel factors regulating the renewal capacity of mesenchymal stem cells and the regenerative capacity of skeletal tissues
        3. Nanoparticles for in vivo tracking of mesenchymal stem cells
        4. Patterned biomineral surfaces and their interactions with osteoclasts


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Artem Kutikov, Kevin A. Reyer and Jie Song. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol. Chem. Phys. 2014; In press.
        2. Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers and Jie Song. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin. Orthop. Relat. Res. 2014; DOI: 10.1007/s11999-014-3841-1.
        3. Artem B. Kutikov, Anvesh Gurijala and Jie Song. A rapid prototyped amphiphilic polymer/hydroxyapatite composite scaffold with hydration-induced self-fixation behavior. Tissue Eng. Part C: Methods. 2014; DOI: 10.1089/ten.tec.2014.0213.
        4. Pingsheng Liu, Jordan D. Skelly and Jie Song. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014; DOI: 10.1016/j.actbio.2014.06.
        5. Pingsheng Liu, Emily Domingue, David C. Ayers and Jie Song. Modification of Ti6Al4V Substrates with Well-defined Zwitterionic Polysulfobetaine Brushes for Improved Surface Mineralization. ACS Appl. Mater. Interfaces. 2014; doi 10.1021/am501967y.
        6. Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90.
          View in: PubMed
        7. Xu J, Feng E, Song J. Bioorthogonally Cross-Linked Hydrogel Network with Precisely Controlled Disintegration Time over a Broad Range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8.
          View in: PubMed
        8. Jianwen Xu, Ellva Feng and Jie Song. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci (Journal cover article). 2014; 131:39822.
        9. Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep; 9(9):8354-64.
          View in: PubMed
        10. Tera Filion and Jie Song. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomat Tissue Eng. 2013; 3(4):486-493.
        11. Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54.
          View in: PubMed
        12. Liang Zhao*, Artem Kutikov*, Jie Shen, Chunying Duan, Jie Song and Gang Han (*co-first author). Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranotics (Journal cover article). 2013; 4(3):249-257.
        13. Xinning Li, Jianwen Xu, Tera M. Filion, David C. Ayers and Jie Song. pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute. Clin. Orthop. Relat. Res. 2013; 471(8):2540-2547.
        14. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7.
          View in: PubMed
        15. Jianwen Xu and Jie Song. Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications, Chapter 11. Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed.Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed. 2012.
        16. Xu J, Filion TM, Prifti F, Song J. Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry. Chem Asian J. (Frontispiece article). 2011; 10(6):2730-2737.
        17. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95.
          View in: PubMed
        18. Xu J, Prifti F, Song J. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules. 2011 Apr 26; 44(8):2660-2667.
          View in: PubMed
        19. Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5067-70.
          View in: PubMed
        20. Chung WJ, Kwon KY, Song J, Lee SW. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir. 2011 Jun 21; 27(12):7620-8.
          View in: PubMed
        21. Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248.
        22. Jianwen Xu and Jie Song. Thermal responsive shape memory polymers for biomedical applications, Chapter 6. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 125-142.
        23. Filion TM, Xu J, Prasad ML, Song J. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials. 2011 Feb; 32(4):985-91.
          View in: PubMed
        24. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11.
          View in: PubMed
        25. Xu J, Song J. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7652-7.
          View in: PubMed
        26. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11.
          View in: PubMed
        27. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107.
          View in: PubMed
        28. Su J, Iomdina E, Tarutta E, Ward B, Song J, Wildsoet CF. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. Exp Eye Res. 2009 Mar; 88(3):445-57.
          View in: PubMed
        29. Song J. A chemical and engineering approach towards "smart" synthetic bone grafts. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):325.
          View in: PubMed
        30. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23.
          View in: PubMed
        31. Song J, Malathong V, Bertozzi CR. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72.
          View in: PubMed
        32. Jie Song and Carolyn R. Bertozzi. Functional polymers for bone tissue engineering applications. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed. 2005; 2:371-392.
        33. Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005; 7(11):999-1004.
        34. Jie Song and , Carolyn R. Bertozzi. Functional Hydrogel-Biomineral Composites Inspired by Natural Bone, Chapter 7. Polymer Biocatalysis and Biomaterials. 2005; 900:96-106.
        35. Song J, Cisar JS, Bertozzi CR. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65.
          View in: PubMed
        36. Cheng Q, Zhu S, Song J, Zhang N. Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin. Analyst. 2004 Apr; 129(4):309-14.
          View in: PubMed
        37. Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands. J. Mater. Chem. 2004; 14:2643-2648.
        38. Jie Song, Raymond C. Stevens and Quan Cheng. Functional Amphiphilic and Bolaamphiphilic Poly(diacetylene) Assemblies with Controlled Optical and Morphological Properties, Chapter 7. Chromogenic Phenomena in Polymers. 2004; 888:96-109.
        39. Song J, Saiz E, Bertozzi CR. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 5; 125(5):1236-43.
          View in: PubMed
        40. Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003; 23(15):2905-2919.
        41. Jie Song, Quan Cheng and Raymond C. Stevens. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem. Phys. Lipids. 2002; 114:203-214.
        42. Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices. 2002; 4(3):213-221.
        43. Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. J Am Chem Soc. 2001 Apr 11; 123(14):3205-13.
          View in: PubMed
        44. Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry. 2001; 12:387-391.
        45. Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999; 121:1851-1861.
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