 Indomethacin
"Indomethacin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
| Descriptor ID |
D007213
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| MeSH Number(s) |
D03.438.473.420
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Indomethacin".
Below are MeSH descriptors whose meaning is more specific than "Indomethacin".
This graph shows the total number of publications written about "Indomethacin" by people in this website by year, and whether "Indomethacin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1981 | 2 | 0 | 2 | | 1982 | 0 | 3 | 3 | | 1983 | 0 | 1 | 1 | | 1986 | 0 | 2 | 2 | | 1987 | 0 | 1 | 1 | | 1989 | 0 | 2 | 2 | | 1990 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1998 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Indomethacin" by people in Profiles.
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Lee J, Martinez N, West K, Kornfeld H. Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production. PLoS One. 2015; 10(4):e0123165.
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Singh R, Visintainer PF. Predictive models for severe intraventricular hemorrhage in preterm infants. J Perinatol. 2014 Oct; 34(10):802.
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Singh R, Gorstein SV, Bednarek F, Chou JH, McGowan EC, Visintainer PF. A predictive model for SIVH risk in preterm infants and targeted indomethacin therapy for prevention. Sci Rep. 2013; 3:2539.
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Prakash S, Shah ND, Soni RK. Secondary hemicrania continua: Case reports and a literature review. J Neurol Sci. 2009 May 15; 280(1-2):29-34.
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Castellani ML, Petrarca C, Frydas S, Conti CM, Salini V, Conti P, Shanmugham LN. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers. 2006 Oct-Dec; 21(4):211-7.
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Condino-Neto A, Whitney C, Newburger PE. Dexamethasone but not indomethacin inhibits human phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity by down-regulating expression of genes encoding oxidase components. J Immunol. 1998 Nov 1; 161(9):4960-7.
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Szabo G, Girouard L, Mandrekar P, Catalano D. Regulation of monocyte IL-12 production: augmentation by lymphocyte contact and acute ethanol treatment, inhibition by elevated intracellular cAMP. Int J Immunopharmacol. 1998 Sep; 20(9):491-503.
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Warner FJ, Burcher E, Carraway R, Conlon JM. Purification, characterization, and spasmogenic activity of neurotensin from the toad Bufo marinus. Peptides. 1998; 19(7):1255-61.
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Mertens WC, Lohmann RC. Oral indomethacin and ranitidine in advanced melanoma: a phase II study. Clin Oncol (R Coll Radiol). 1996; 8(2):112-5.
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Nompleggi DJ, Beinborn M, Roy A, Wolfe MM. The effect of recombinant cytokines on [14C]-aminopyrine accumulation by isolated canine parietal cells. J Pharmacol Exp Ther. 1994 Aug; 270(2):440-5.
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