"Troponin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019209
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| MeSH Number(s) |
D05.500.945.900 D05.750.078.730.825.900 D12.776.157.125.900 D12.776.210.500.910.900 D12.776.220.525.825.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin C".
Below are MeSH descriptors whose meaning is more specific than "Troponin C".
This graph shows the total number of publications written about "Troponin C" by people in this website by year, and whether "Troponin C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Troponin C" by people in Profiles.
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Galinska A, Hatch V, Craig R, Murphy AM, Van Eyk JE, Wang CL, Lehman W, Foster DB. The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments. Circ Res. 2010 Mar 05; 106(4):705-11.
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Luo Y, Leszyk J, Li B, Gergely J, Tao T. Proximity relationships between residue 6 of troponin I and residues in troponin C: further evidence for extended conformation of troponin C in the troponin complex. Biochemistry. 2000 Dec 19; 39(50):15306-15.
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Luo Y, Leszyk J, Qian Y, Gergely J, Tao T. Residues 48 and 82 at the N-terminal hydrophobic pocket of rabbit skeletal muscle troponin-C photo-cross-link to Met121 of troponin-I. Biochemistry. 1999 May 18; 38(20):6678-88.
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Leszyk J, Tao T, Nuwaysir LM, Gergely J. Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21. J Muscle Res Cell Motil. 1998 Jun; 19(5):479-90.
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Leszyk J, Grabarek Z, Gergely J, Collins JH. Characterization of zero-length cross-links between rabbit skeletal muscle troponin C and troponin I: evidence for direct interaction between the inhibitory region of troponin I and the NH2-terminal, regulatory domain of troponin C. Biochemistry. 1990 Jan 09; 29(1):299-304.
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Leszyk J, Collins JH, Leavis PC, Tao T. Cross-linking of rabbit skeletal muscle troponin subunits: labeling of cysteine-98 of troponin C with 4-maleimidobenzophenone and analysis of products formed in the binary complex with troponin T and the ternary complex with troponins I and T. Biochemistry. 1988 Sep 06; 27(18):6983-7.
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Leszyk J, Collins JH, Leavis PC, Tao T. Cross-linking of rabbit skeletal muscle troponin with the photoactive reagent 4-maleimidobenzophenone: identification of residues in troponin I that are close to cysteine-98 of troponin C. Biochemistry. 1987 Nov 03; 26(22):7042-7.