"Chediak-Higashi Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
| Descriptor ID |
D002609
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| MeSH Number(s) |
C15.378.553.774.257 C20.673.774.257
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| Concept/Terms |
Chediak-Higashi Syndrome- Chediak-Higashi Syndrome
- Chediak Higashi Syndrome
- Syndrome, Chediak-Higashi
- Oculocutaneous Albinism with Leukocyte Defect
- Chediak-Steinbrinck-Higashi Syndrome
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Below are MeSH descriptors whose meaning is more general than "Chediak-Higashi Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Chediak-Higashi Syndrome".
This graph shows the total number of publications written about "Chediak-Higashi Syndrome" by people in this website by year, and whether "Chediak-Higashi Syndrome" was a major or minor topic of these publications.
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Below are the most recent publications written about "Chediak-Higashi Syndrome" by people in Profiles.
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Styrt B, Pollack CR, Klempner MS. An abnormal calcium uptake pump in Chediak-Higashi neutrophil lysosomes. J Leukoc Biol. 1988 Aug; 44(2):130-5.
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Newburger PE, Speier C, Stock JL, Perrine SP, Greenberger JS. Chediak-Higashi syndrome: studies in long-term bone marrow culture. Exp Hematol. 1985 Feb; 13(2):117-22.
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Kazmierowski JA, Elin RJ, Reynolds HY, Durbin WA, Wolff SM. Chediak-Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation. Blood. 1976 Apr; 47(4):555-9.