Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction. CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages. CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis. Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection. Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection.

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design. Immune dysregulation of diabetes in tuberculosis. Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis. Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans. The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large-Scale Guide to Genetic Conditional Essentiality.