Gene Products, pol

"Gene Products, pol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Retroviral proteins coded by the pol gene. They are usually synthesized as a protein precursor (POLYPROTEINS) and later cleaved into final products that include reverse transcriptase, endonuclease/integrase, and viral protease. Sometimes they are synthesized as a gag-pol fusion protein (FUSION PROTEINS, GAG-POL). pol is short for polymerase, the enzyme class of reverse transcriptase.

Descriptor ID	D015684
MeSH Number(s)	D12.776.775.360 D12.776.964.775.375 D12.776.964.970.600.850.375
Concept/Terms	Gene Products, pol Gene Products, pol pol Gene Products pol Protein Protein, pol pol Polyprotein Polyprotein, pol pol Polyproteins Polyproteins, pol Gene Product, pol pol Gene Product

Below are MeSH descriptors whose meaning is more general than "Gene Products, pol".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Polyproteins [D12.776.775]
Gene Products, pol [D12.776.775.360]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, pol [D12.776.964.775.375]
Viral Structural Proteins [D12.776.964.970]
Nucleocapsid Proteins [D12.776.964.970.600]
Viral Core Proteins [D12.776.964.970.600.850]
Gene Products, pol [D12.776.964.970.600.850.375]

Below are MeSH descriptors whose meaning is related to "Gene Products, pol".

Below are MeSH descriptors whose meaning is more specific than "Gene Products, pol".

Gene Products, pol
Fusion Proteins, gag-pol
pol Gene Products, Human Immunodeficiency Virus

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Products, pol" by people in this website by year, and whether "Gene Products, pol" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	2	0	2
2012	0	1	1
2015	0	1	1
2019	0	1	1

Below are the most recent publications written about "Gene Products, pol" by people in Profiles.

Yu T, Koppetsch BS, Pagliarani S, Johnston S, Silverstein NJ, Luban J, Chappell K, Weng Z, Theurkauf WE. The piRNA Response to Retroviral Invasion of the Koala Genome. Cell. 2019 10 17; 179(3):632-643.e12.

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Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. 2015 Jul 17; 349(6245):320-4.

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Reynolds MR, Weiler AM, Piaskowski SM, Piatak M, Robertson HT, Allison DB, Bett AJ, Casimiro DR, Shiver JW, Wilson NA, Lifson JD, Koff WC, Watkins DI. A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge. Vaccine. 2012 Jun 22; 30(30):4465-75.

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Davis DA, Soule EE, Davidoff KS, Daniels SI, Naiman NE, Yarchoan R. Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing. Antimicrob Agents Chemother. 2012 Jul; 56(7):3620-8.

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Apetrei C, Descamps D, Collin G, Robertson DL, Pandrea I, Groza P, Prisecariu L, Teodorescu I, Luca V, Brun-V?zinet F. HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapy. AIDS Res Hum Retroviruses. 2003 Dec; 19(12):1155-1161.

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Kurt N, Haliloglu T, Schiffer CA. Structure-based prediction of potential binding and nonbinding peptides to HIV-1 protease. Biophys J. 2003 Aug; 85(2):853-63.

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Alexander L, Denekamp L, Czajak S, Desrosiers RC. Suboptimal nucleotides in the infectious, pathogenic simian immunodeficiency virus clone SIVmac239. J Virol. 2001 Apr; 75(8):4019-22.

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Purohit P, Dupont S, Stevenson M, Green MR. Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection. RNA. 2001 Apr; 7(4):576-84.

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Luban J, Goff SP. Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA. J Virol. 1994 Jun; 68(6):3784-93.

View in: PubMed

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