"Genes, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA sequences that form the coding region for a protein that down-regulates the expression of human immunodeficiency virus (HIV). nef is short for negative factor.
| Descriptor ID |
D015754
|
| MeSH Number(s) |
G05.360.340.024.340.364.875.600 G05.360.340.024.340.425.413 G05.360.340.358.024.875.600 G05.360.340.358.840.500.600
|
| Concept/Terms |
Genes, nef- Genes, nef
- nef Genes
- Gene, nef
- nef Gene
- HIV-3'-orf Genes
- Gene, HIV-3'-orf
- Genes, HIV-3'-orf
- HIV 3' orf Genes
- HIV-3'-orf Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, nef".
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Genome [G05.360.340]
- Genome Components [G05.360.340.024]
- Genes [G05.360.340.024.340]
- Genes, Microbial [G05.360.340.024.340.364]
- Genes, Viral [G05.360.340.024.340.364.875]
- Genes, nef [G05.360.340.024.340.364.875.600]
- Genes, Regulator [G05.360.340.024.340.425]
- Genes, nef [G05.360.340.024.340.425.413]
- Genome, Microbial [G05.360.340.358]
- Genes, Microbial [G05.360.340.358.024]
- Genes, Viral [G05.360.340.358.024.875]
- Genes, nef [G05.360.340.358.024.875.600]
- Genome, Viral [G05.360.340.358.840]
- Genes, Viral [G05.360.340.358.840.500]
- Genes, nef [G05.360.340.358.840.500.600]
Below are MeSH descriptors whose meaning is more specific than "Genes, nef".
This graph shows the total number of publications written about "Genes, nef" by people in this website by year, and whether "Genes, nef" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, nef" by people in Profiles.
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Lai RP, Yan J, Heeney J, McClure MO, G?ttlinger H, Luban J, Pizzato M. Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. PLoS Pathog. 2011 Dec; 7(12):e1002442.
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Sanchez-Merino V, Nie S, Luzuriaga K. HIV-1-specific CD8+ T cell responses and viral evolution in women and infants. J Immunol. 2005 Nov 15; 175(10):6976-86.
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Kim EY, Busch M, Abel K, Fritts L, Bustamante P, Stanton J, Lu D, Wu S, Glowczwskie J, Rourke T, Bogdan D, Piatak M, Lifson JD, Desrosiers RC, Wolinsky S, Miller CJ. Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef. J Virol. 2005 Apr; 79(8):4886-95.
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Schindler M, W?rfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, M?nch J, Kirchhoff F. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol. 2003 Oct; 77(19):10548-56.
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Alexander L, Illyinskii PO, Lang SM, Means RE, Lifson J, Mansfield K, Desrosiers RC. Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys. J Virol. 2003 Jun; 77(12):6823-35.
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Wyand MS, Manson K, Montefiori DC, Lifson JD, Johnson RP, Desrosiers RC. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J Virol. 1999 Oct; 73(10):8356-63.
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Greenough TC, Sullivan JL, Desrosiers RC. Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1. N Engl J Med. 1999 Jan 21; 340(3):236-7.
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Howe AY, Jung JU, Desrosiers RC. Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2. J Virol. 1998 Dec; 72(12):9827-34.
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Sasseville VG, Rottman JB, Du Z, Veazey R, Knight HL, Caunt D, Desrosiers RC, Lackner AA. Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239. J Invest Dermatol. 1998 Jun; 110(6):894-901.
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Wooley DP, Smith RA, Czajak S, Desrosiers RC. Direct demonstration of retroviral recombination in a rhesus monkey. J Virol. 1997 Dec; 71(12):9650-3.