"Heparin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
| Descriptor ID |
D006493
|
| MeSH Number(s) |
D09.698.373.400
|
| Concept/Terms |
Heparin- Heparin
- Unfractionated Heparin
- Heparin, Unfractionated
- Heparinic Acid
|
Below are MeSH descriptors whose meaning is more general than "Heparin".
Below are MeSH descriptors whose meaning is more specific than "Heparin".
This graph shows the total number of publications written about "Heparin" by people in this website by year, and whether "Heparin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 4 | 4 |
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 4 | 5 |
| 2006 | 2 | 2 | 4 |
| 2007 | 4 | 0 | 4 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 3 | 1 | 4 |
| 2011 | 0 | 3 | 3 |
| 2012 | 1 | 2 | 3 |
| 2013 | 5 | 0 | 5 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 3 | 1 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 2 | 2 |
| 2020 | 3 | 1 | 4 |
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Below are the most recent publications written about "Heparin" by people in Profiles.
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Yang Y, Du Y, Kaltashov IA. The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor. Anal Chem. 2020 08 18; 92(16):10930-10934.
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Niu C, Zhao Y, Bobst CE, Savinov SN, Kaltashov IA. Identification of Protein Recognition Elements within Heparin Chains Using Enzymatic Foot-Printing in Solution and Online SEC/MS. Anal Chem. 2020 06 02; 92(11):7565-7573.
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Niu C, Yang Y, Huynh A, Nazy I, Kaltashov IA. Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly. Biophys J. 2020 10 06; 119(7):1371-1379.
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Zhao Y, Kaltashov IA. Evaluation of top-down mass spectrometry and ion-mobility spectroscopy as a means of mapping protein-binding motifs within heparin chains. Analyst. 2020 Apr 14; 145(8):3090-3099.
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Tanhehco YC, Zantek ND, Alsammak M, Chhibber V, Li Y, Becker J, Wu DW, Foster T, Wehrli G. Vascular access practices for therapeutic apheresis: Results of a survey. J Clin Apher. 2019 Oct; 34(5):571-578.
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Fraielli K, Patel D, Wang D, Sargent K, Gore J. Successful use of fondaparinux in the setting of heparin-induced thrombocytopenia with thrombosis confirmed by serotonin-release assay and Factor V Leiden. J Clin Pharm Ther. 2019 Oct; 44(5):809-812.
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Raulli SJ, Cheng TW, Farber A, Eslami MH, Kalish JA, Jones DW, Rybin DV, Nuhn M, Gautam A, Siracuse JJ. Intraoperative Heparin Use during Upper Extremity Arteriovenous Access Creation Does Not Affect Outcomes. Ann Vasc Surg. 2019 Feb; 55:216-221.
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Minsky BB, Abzalimov RR, Niu C, Zhao Y, Kirsch Z, Dubin PL, Savinov SN, Kaltashov IA. Mass Spectrometry Reveals a Multifaceted Role of Glycosaminoglycan Chains in Factor Xa Inactivation by Antithrombin. Biochemistry. 2018 08 14; 57(32):4880-4890.
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Ngernyuang N, Yan W, Schwartz LM, Oh D, Liu YB, Chen H, Shao R. A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40. Neoplasia. 2018 02; 20(2):182-192.
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Raschke RA, Gallo T, Curry SC, Whiting T, Padilla-Jones A, Warkentin TE, Puri A. Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia. J Thromb Haemost. 2017 08; 15(8):1640-1645.