Sodium Channel Blockers

"Sodium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.

Descriptor ID	D026941
MeSH Number(s)	D27.505.519.562.750 D27.505.954.411.720
Concept/Terms	Sodium Channel Blockers Sodium Channel Blockers Sodium Channel Inhibitors Channel Inhibitors, Sodium Inhibitors, Sodium Channel Channel Blockers, Sodium

Below are MeSH descriptors whose meaning is more general than "Sodium Channel Blockers".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Membrane Transport Modulators [D27.505.519.562]
Sodium Channel Blockers [D27.505.519.562.750]
Therapeutic Uses [D27.505.954]
Cardiovascular Agents [D27.505.954.411]
Sodium Channel Blockers [D27.505.954.411.720]

Below are MeSH descriptors whose meaning is more specific than "Sodium Channel Blockers".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sodium Channel Blockers" by people in this website by year, and whether "Sodium Channel Blockers" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2005	0	2	2
2008	0	1	1
2010	0	1	1
2011	0	1	1
2016	1	0	1
2017	0	1	1

Below are the most recent publications written about "Sodium Channel Blockers" by people in Profiles.

Strege PR, Knutson K, Eggers SJ, Li JH, Wang F, Linden D, Szurszewski JH, Milescu L, Leiter AB, Farrugia G, Beyder A. Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. Sci Rep. 2017 Nov 15; 7(1):15650.

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Hasegawa Y, Mao W, Saha S, Gunner G, Kolpakova J, Martin GE, Futai K. Luciferase shRNA Presents off-Target Effects on Voltage-Gated Ion Channels in Mouse Hippocampal Pyramidal Neurons. eNeuro. 2017 Sep-Oct; 4(5).

View in: PubMed
Olivotto I, Hellawell JL, Farzaneh-Far R, Blair C, Coppini R, Myers J, Belardinelli L, Maron MS. Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial. Circ Heart Fail. 2016 Mar; 9(3):e002764.

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Sim S, Antolin S, Lin CW, Lin Y, Lin YX, Lois C. Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require Npas4. J Neurosci. 2013 May 01; 33(18):7928-40.

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Cheng SJ, Chen CC, Yang HW, Chang YT, Bai SW, Chen CC, Yen CT, Min MY. Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid-induced muscle pain mice. J Neurosci. 2011 Feb 09; 31(6):2258-70.

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Kan MC, Oruganty-Das A, Cooper-Morgan A, Jin G, Swanger SA, Bassell GJ, Florman H, van Leyen K, Richter JD. CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol. 2010 Dec; 30(24):5658-71.

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Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73.

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Hern?ndez-Gonz?lez EO, Sosnik J, Edwards J, Acevedo JJ, Mendoza-Lujambio I, L?pez-Gonz?lez I, Demarco I, Wertheimer E, Darszon A, Visconti PE. Sodium and epithelial sodium channels participate in the regulation of the capacitation-associated hyperpolarization in mouse sperm. J Biol Chem. 2006 Mar 03; 281(9):5623-33.

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Grueter BA, Winder DG. Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis. Neuropsychopharmacology. 2005 Jul; 30(7):1302-11.

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Chaudhry GM, Haffajee CI. Antiarrhythmic agents and proarrhythmia. Crit Care Med. 2000 Oct; 28(10 Suppl):N158-64.

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