"Digitonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.
| Descriptor ID |
D004072
|
| MeSH Number(s) |
D04.210.500.155.580.130.500.236 D09.408.180.261.236
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Digitonin".
Below are MeSH descriptors whose meaning is more specific than "Digitonin".
This graph shows the total number of publications written about "Digitonin" by people in this website by year, and whether "Digitonin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Digitonin" by people in Profiles.
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Baron MJ, Bolduc GR, Goldberg MB, Aup?rin TC, Madoff LC. Alpha C protein of group B Streptococcus binds host cell surface glycosaminoglycan and enters cells by an actin-dependent mechanism. J Biol Chem. 2004 Jun 04; 279(23):24714-23.
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Burkart A, Samii B, Corvera S, Shpetner HS. Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem. 2003 May 16; 278(20):18360-7.
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Acharya U, Mallabiabarrena A, Acharya JK, Malhotra V. Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis. Cell. 1998 Jan 23; 92(2):183-92.
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Styrt B, Johnson PC, Klempner MS. Differential lysis of plasma membranes and granules of human neutrophils by digitonin. Tissue Cell. 1985; 17(6):793-800.
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Haveman J, Lavorel J. Identification of the 120 mus phase in the decay of delayed fluorescence in spinach chloroplasts and subchloroplast particles as the intrinsic back reaction. The dependence of the level of this phase on the thylakoids internal pH. Biochim Biophys Acta. 1975 Dec 11; 408(3):269-38.