 Platelet Glycoprotein GPIb-IX Complex
"Platelet Glycoprotein GPIb-IX Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
| Descriptor ID |
D019038
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| MeSH Number(s) |
D12.776.395.550.625.460 D12.776.395.550.625.800.780 D12.776.543.550.625.460 D12.776.543.550.625.800.780 D12.776.543.750.705.675.568
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| Concept/Terms |
CD42d Antigen- CD42d Antigen
- Antigen, CD42d
- CD42d Antigens
- Antigens, CD42d
CD42b Antigens- CD42b Antigens
- Glycoprotein Ib alpha
- CD42b Antigen
- Antigen, CD42b
- Antigens, CD42b
CD42c Antigens- CD42c Antigens
- Glycoprotein Ib beta
- CD42c Antigen
- Antigen, CD42c
- Antigens, CD42c
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Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIb-IX Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIb-IX Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIb-IX Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in Profiles.
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Frelinger AL, Grace RF, Gerrits AJ, Berny-Lang MA, Brown T, Carmichael SL, Neufeld EJ, Michelson AD. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015 Aug 13; 126(7):873-9.
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Jones CI, Sage T, Moraes LA, Vaiyapuri S, Hussain U, Tucker KL, Barrett NE, Gibbins JM. Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin aIIbß3. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1968-76.
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Bednarek FJ, Bean S, Barnard MR, Frelinger AL, Michelson AD. The platelet hyporeactivity of extremely low birth weight neonates is age-dependent. Thromb Res. 2009 May; 124(1):42-5.
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Leytin V, Allen DJ, Mykhaylov S, Lyubimov E, Freedman J. Thrombin-triggered platelet apoptosis. J Thromb Haemost. 2006 Dec; 4(12):2656-63.
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Barnard MR, Linden MD, Frelinger AL, Li Y, Fox ML, Furman MI, Michelson AD. Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activity. J Thromb Haemost. 2005 Nov; 3(11):2563-70.
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Michelson AD, Barnard MR, Krueger LA, Frelinger AL, Furman MI. Evaluation of platelet function by flow cytometry. Methods. 2000 Jul; 21(3):259-70.
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Mody M, Lazarus AH, Semple JW, Freedman J. Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant. Transfus Med. 1999 Jun; 9(2):147-54.
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Kelton JG, Smith JW, Horsewood P, Warner MN, Warkentin TE, Finberg RW, Hayward CP. ABH antigens on human platelets: expression on the glycosyl phosphatidylinositol-anchored protein CD109. J Lab Clin Med. 1998 Aug; 132(2):142-8.
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Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54.
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