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Mai K ElMallah MD

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North S5-860
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DivisionPediatric Pulmonology

    Collapse Biography 
    Collapse education and training
    University of Florida, Gainesville, FL, United StatesMSClinical Investigation
    Queens University Belfast, Belfast, , MD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cocanougher BT, Liu SW, Francescatto L, Behura A, Anneling M, Jackson DG, Deak KL, Hornik CD, ElMallah MK, Pizoli CE, Smith EC, Queenie Tan KG, McDonald MT. The severity of MUSK pathogenic variants is predicted by the protein domain they disrupt. HGG Adv. 2024 Apr 01; 100288. PMID: 38566418.
    2. Williams SP, Hern?ndez Rodr?guez MY, Cass B, Ali-Dinar T, ElMallah MK. Pulmonary manifestations of STAC3 disorder: A case series. Pediatr Pulmonol. 2024 Mar; 59(3):794-797. PMID: 38088138.
      Citations:    Fields:    
    3. Thamby J, Prange L, Boggs A, Subei MO, Myers C, Uchitel J, ElMallah M, Bartlett-Lee B, Riviello JJ, Mikati MA. Characteristics of non-sleep related apneas in children with alternating hemiplegia of childhood. Eur J Paediatr Neurol. 2024 Jan; 48:101-108. PMID: 38096596.
      Citations:    Fields:    
    4. Konkimalla A, Konishi S, Macadlo L, Kobayashi Y, Farino ZJ, Miyashita N, El Haddad L, Morowitz J, Barkauskas CE, Agarwal P, Souma T, ElMallah MK, Tata A, Tata PR. Transitional cell states sculpt tissue topology during lung regeneration. Cell Stem Cell. 2023 11 02; 30(11):1486-1502.e9. PMID: 37922879.
      Citations: 1     Fields:    Translation:Cells
    5. El Haddad L, Khan M, Soufny R, Mummy D, Driehuys B, Mansour W, Kishnani PS, ElMallah MK. Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives. Ther Clin Risk Manag. 2023; 19:713-729. PMID: 37680303.
    6. El Haddad L, Lai E, Murthy PKL, Biswas DD, Soufny R, Roger AL, Tata PR, ElMallah MK. GAA deficiency disrupts distal airway cells in Pompe disease. Am J Physiol Lung Cell Mol Physiol. 2023 09 01; 325(3):L288-L298. PMID: 37366541.
      Citations:    Fields:    Translation:Humans
    7. Gromova A, Cha B, Robinson EM, Strickland LM, Nguyen N, ElMallah MK, Cortes CJ, La Spada AR. X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease. Acta Neuropathol Commun. 2023 06 02; 11(1):90. PMID: 37269008.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Leon-Astudillo C, Okorie CUA, McCown MY, Dy FJ, Puranik S, Prero M, ElMallah MK, Treat L, Gross JE. ATS Core Curriculum 2022. Pediatric Pulmonary Medicine: Updates in pediatric neuromuscular disease. Pediatr Pulmonol. 2023 Jul; 58(7):1866-1874. PMID: 37144867.
      Citations:    Fields:    Translation:Humans
    9. Scott Z, Zhou C, Tracy E, ElMallah MK, Yousef S. Congenital lobar emphysema in monozygotic twins. Respir Med Case Rep. 2023; 43:101842. PMID: 37077236.
    10. Biswas DD, El Haddad L, Sethi R, Huston ML, Lai E, Abdelbarr MM, Mhandire DZ, ElMallah MK. Neuro-respiratory pathology in spinocerebellar ataxia. J Neurol Sci. 2022 12 15; 443:120493. PMID: 36410186.
      Citations: 1     Fields:    Translation:Humans
    11. Gonzalez TJ, Simon KE, Blondel LO, Fanous MM, Roger AL, Maysonet MS, Devlin GW, Smith TJ, Oh DK, Havlik LP, Castellanos Rivera RM, Piedrahita JA, ElMallah MK, Gersbach CA, Asokan A. Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing. Nat Commun. 2022 10 10; 13(1):5947. PMID: 36210364.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Mhandire DZ, Burns DP, Roger AL, O'Halloran KD, ElMallah MK. Breathing in Duchenne muscular dystrophy: translation to therapy. J Physiol. 2022 08; 600(15):3465-3482. PMID: 35620971.
      Citations: 3     Fields:    Translation:HumansAnimals
    13. Roger AL, Sethi R, Huston ML, Scarrow E, Bao-Dai J, Lai E, Biswas DD, El Haddad L, Strickland LM, Kishnani PS, ElMallah MK. What's new and what's next for gene therapy in Pompe disease? Expert Opin Biol Ther. 2022 09; 22(9):1117-1135. PMID: 35428407.
      Citations: 3     Fields:    Translation:HumansAnimals
    14. Fusco AF, Pucci LA, Switonski PM, Biswas DD, McCall AL, Kahn AF, Dhindsa JS, Strickland LM, La Spada AR, ElMallah MK. Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7. Dis Model Mech. 2021 07 01; 14(7). PMID: 34160002.
      Citations: 6     Fields:    Translation:HumansAnimals
    15. Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, Pagadala P, Wallace K, Poe J, Gunduz T, Asokan A, Koeberl DD, ElMallah MK, Mikati MA. Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood. Hum Gene Ther. 2021 04; 32(7-8):405-419. PMID: 33577387.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. Lu P, ElMallah MK, Liu Z, Wu C, Chen J, Lifshitz LM, ZhuGe R. Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. J Cell Physiol. 2021 09; 236(9):6407-6423. PMID: 33559206.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. McCall AL, Dhindsa JS, Bailey AM, Pucci LA, Strickland LM, ElMallah MK. Glycogen accumulation in smooth muscle of a Pompe disease mouse model. J Smooth Muscle Res. 2021; 57(0):8-18. PMID: 33883348.
      Citations: 4     Fields:    Translation:HumansAnimals
    18. McCall AL, Dhindsa JS, Pucci LA, Khan AF, Fusco AF, Biswas DD, Strickland LM, Tseng HC, ElMallah MK. Corrigendum to "Respiratory pathology in the optn-/- mouse model of amyotrophic lateral sclerosis" [Respir. Physiol. Neurobiol. 282 (2020) 103525]. Respir Physiol Neurobiol. 2021 Feb; 284:103570. PMID: 33214085.
      Citations:    Fields:    
    19. McCall AL, Dhindsa JS, Pucci LA, Kahn AF, Fusco AF, Biswas DD, Strickland LM, Tseng HC, ElMallah MK. Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. Respir Physiol Neurobiol. 2020 11; 282:103525. PMID: 32805420.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Crayle J, Elmallah M, Sleasman J, Bedlack R. Total serum immunoglobulin A in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2021 02; 22(1-2):61-65. PMID: 32672072.
      Citations:    Fields:    Translation:Humans
    21. Lind LA, Andel EM, McCall AL, Dhindsa JS, Johnson KA, Stricklin OE, Mueller C, ElMallah MK, Lever TE, Nichols NL. Intralingual Administration of AAVrh10-miRSOD1 Improves Respiratory But Not Swallowing Function in a Superoxide Dismutase-1 Mouse Model of Amyotrophic Lateral Sclerosis. Hum Gene Ther. 2020 08; 31(15-16):828-838. PMID: 32498636.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Dhindsa JS, McCall AL, Strickland LM, Fusco AF, Kahn AF, ElMallah MK. Motor axonopathies in a mouse model of Duchenne muscular dystrophy. Sci Rep. 2020 06 02; 10(1):8967. PMID: 32488044.
      Citations: 1     Fields:    Translation:AnimalsCells
    23. Fusco AF, McCall AL, Dhindsa JS, Zheng L, Bailey A, Kahn AF, ElMallah MK. The Respiratory Phenotype of Pompe Disease Mouse Models. Int J Mol Sci. 2020 Mar 24; 21(6). PMID: 32214050.
      Citations: 5     Fields:    Translation:Animals
    24. Khan AA, Case LE, Herbert M, DeArmey S, Jones H, Crisp K, Zimmerman K, ElMallah MK, Young SP, Kishnani PS. Higher dosing of alglucosidase alfa improves outcomes in children with Pompe disease: a clinical study and review of the literature. Genet Med. 2020 05; 22(5):898-907. PMID: 31904026.
      Citations: 22     Fields:    Translation:Humans
    25. ElMallah MK, Desai AK, Nading EB, DeArmey S, Kravitz RM, Kishnani PS. Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series. Pediatr Pulmonol. 2020 03; 55(3):674-681. PMID: 31899940.
      Citations: 7     Fields:    Translation:Humans
    26. Keeler AM, Zieger M, Semple C, Pucci L, Veinbachs A, Brown RH, Mueller C, ElMallah MK. Intralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:246-257. PMID: 31970202.
    27. Han SO, Li S, McCall A, Arnson B, Everitt JI, Zhang H, Young SP, ElMallah MK, Koeberl DD. Comparisons of Infant and Adult Mice Reveal Age Effects for Liver Depot Gene Therapy in Pompe Disease. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:133-142. PMID: 31909086.
    28. Fusco AF, McCall AL, Dhindsa JS, Pucci LA, Strickland LM, Kahn AF, ElMallah MK. The Respiratory Phenotype of Rodent Models of Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia. J Neuroinflamm Neurodegener Dis. 2019; 3(1). PMID: 31893284.
    29. Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019 Sep 27; 19:916-926. PMID: 31518900.
    30. Zieger M, Keeler AM, Flotte TR, ElMallah MK. AAV9 gene replacement therapy for respiratory insufficiency in very-long chain acyl-CoA dehydrogenase deficiency. J Inherit Metab Dis. 2019 09; 42(5):870-877. PMID: 30993714.
      Citations: 4     Fields:    Translation:AnimalsCells
    31. McCall AL, ElMallah MK. Macroglossia, Motor Neuron Pathology, and Airway Malacia Contribute to Respiratory Insufficiency in Pompe Disease: A Commentary on Molecular Pathways and Respiratory Involvement in Lysosomal Storage Diseases. Int J Mol Sci. 2019 Feb 11; 20(3). PMID: 30754627.
      Citations: 2     Fields:    Translation:Humans
    32. Keeler AM, Zieger M, Todeasa SH, McCall AL, Gifford JC, Birsak S, Choudhury SR, Byrne BJ, Sena-Esteves M, ElMallah MK. Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease. Hum Gene Ther. 2019 01; 30(1):57-68. PMID: 29901418.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    33. Borel F, Sun H, Zieger M, Cox A, Cardozo B, Li W, Oliveira G, Davis A, Gruntman A, Flotte TR, Brodsky MH, Hoffman AM, Elmallah MK, Mueller C. Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2788-2793. PMID: 29453277.
      Citations: 43     Fields:    Translation:HumansAnimals
    34. McCall AL, Salemi J, Bhanap P, Strickland LM, Elmallah MK. The impact of Pompe disease on smooth muscle: a review. J Smooth Muscle Res. 2018; 54(0):100-118. PMID: 30787211.
      Citations: 19     Fields:    Translation:HumansAnimals
    35. Trivedi M, ElMallah M, Bailey E, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e332-e335. PMID: 28892548.
      Citations: 7     Fields:    Translation:Humans
    36. ElMallah M, Bailey E, Trivedi M, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e336-e339. PMID: 28892549.
      Citations: 6     Fields:    Translation:Humans
    37. Keeler AM, Liu D, Zieger M, Xiong L, Salemi J, Bellv? K, Byrne BJ, Fuller DD, ZhuGe R, ElMallah MK. Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L873-L881. PMID: 28336814.
      Citations: 14     Fields:    Translation:AnimalsCells
    38. Stoica L, Keeler AM, Xiong L, Kalfopoulos M, Desrochers K, Brown RH, Sena-Esteves M, Flotte TR, ElMallah MK. Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model. Am J Respir Cell Mol Biol. 2017 03; 56(3):405-408. PMID: 28248134.
      Citations: 7     Fields:    Translation:HumansAnimals
    39. Kalfopoulos M, Wetmore K, ElMallah MK. Pathophysiology of Alpha-1 Antitrypsin Lung Disease. Methods Mol Biol. 2017; 1639:9-19. PMID: 28752442.
      Citations: 7     Fields:    Translation:Humans
    40. Stoica L, Todeasa SH, Cabrera GT, Salameh JS, ElMallah MK, Mueller C, Brown RH, Sena-Esteves M. Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model. Ann Neurol. 2016 Apr; 79(4):687-700. PMID: 26891182.
      Citations: 50     Fields:    Translation:AnimalsCells
    41. Turner SM, Hoyt AK, ElMallah MK, Falk DJ, Byrne BJ, Fuller DD. Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. Respir Physiol Neurobiol. 2016 Jun 15; 227:48-55. PMID: 26921786.
      Citations: 29     Fields:    Translation:AnimalsCells
    42. Loring HS, ElMallah MK, Flotte TR. Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans. Hum Gene Ther Methods. 2016 Apr; 27(2):49-58. PMID: 26895204.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    43. Borel F, Gernoux G, Cardozo B, Metterville JP, Toro Cabrera GC, Song L, Su Q, Gao GP, Elmallah MK, Brown RH, Mueller C. Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates. Hum Gene Ther. 2016 01; 27(1):19-31. PMID: 26710998.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    44. ElMallah MK, Stanley DA, Lee KZ, Turner SM, Streeter KA, Baekey DM, Fuller DD. Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice. J Neurophysiol. 2016 Mar; 115(3):1372-80. PMID: 26683067.
      Citations: 6     Fields:    Translation:Animals
    45. ElMallah MK, Pagliardini S, Turner SM, Cerreta AJ, Falk DJ, Byrne BJ, Greer JJ, Fuller DD. Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):326-35. PMID: 25569118.
      Citations: 26     Fields:    Translation:Animals
    46. Bacewicz A, Wang W, Ashouri J, ElMallah MK. Children with Chronic Lung Disease: Facilitating Smoking Cessation for their Caregivers. J Community Health. 2015 Jun; 40(3):409-13. PMID: 25245161.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    47. Halawa M, Abu-Hasan MN, ElMallah MK. Hereditary mucoepithelial dysplasia and severe respiratory distress. Respir Med Case Rep. 2015; 15:27-9. PMID: 26236594.
    48. Falk DJ, Todd AG, Lee S, Soustek MS, ElMallah MK, Fuller DD, Notterpek L, Byrne BJ. Peripheral nerve and neuromuscular junction pathology in Pompe disease. Hum Mol Genet. 2015 Feb 01; 24(3):625-36. PMID: 25217571.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    49. Abu-Hasan M, Elmallah M, Neal D, Brookes J. Salivary Amylase Level in Bronchoalveolar Fluid as a Marker of Chronic Pulmonary Aspiration in Children. Pediatr Allergy Immunol Pulmonol. 2014 Sep 01; 27(3):115-119. PMID: 26697264.
      Citations: 6     Fields:    
    50. Elmallah MK, Falk DJ, Nayak S, Federico RA, Sandhu MS, Poirier A, Byrne BJ, Fuller DD. Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice. Mol Ther. 2014 Apr; 22(4):702-12. PMID: 24336173.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    51. Fuller DD, ElMallah MK, Smith BK, Corti M, Lawson LA, Falk DJ, Byrne BJ. The respiratory neuromuscular system in Pompe disease. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):241-9. PMID: 23797185.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    52. Falk DJ, Mah CS, Soustek MS, Lee KZ, Elmallah MK, Cloutier DA, Fuller DD, Byrne BJ. Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease. Mol Ther. 2013 Sep; 21(9):1661-7. PMID: 23732990.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    53. ElMallah MK, Falk DJ, Lane MA, Conlon TJ, Lee KZ, Shafi NI, Reier PJ, Byrne BJ, Fuller DD. Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9. Hum Gene Ther Methods. 2012 Apr; 23(2):148-56. PMID: 22693957.
      Citations: 32     Fields:    Translation:AnimalsCells
    54. Elmallah MK, Hendeles L, Hamilton RG, Capen C, Schuler PM. Management of patients with cystic fibrosis and allergic bronchopulmonary aspergillosis using anti-immunoglobulin e therapy (omalizumab). J Pediatr Pharmacol Ther. 2012 Jan; 17(1):88-92. PMID: 23118662.
    55. Elmallah MK, Khan Y, Hochhaus G, Shuster JJ, Hendeles L. Systemic exposure to fluticasone MDI delivered through antistatic chambers. J Allergy Clin Immunol. 2011 Nov; 128(5):1113-5.e1-3. PMID: 21783234.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    56. Lee KZ, Qiu K, Sandhu MS, Elmallah MK, Falk DJ, Lane MA, Reier PJ, Byrne BJ, Fuller DD. Hypoglossal neuropathology and respiratory activity in pompe mice. Front Physiol. 2011; 2:31. PMID: 21747768.
    57. Byrne BJ, Falk DJ, Pacak CA, Nayak S, Herzog RW, Elder ME, Collins SW, Conlon TJ, Clement N, Cleaver BD, Cloutier DA, Porvasnik SL, Islam S, Elmallah MK, Martin A, Smith BK, Fuller DD, Lawson LA, Mah CS. Pompe disease gene therapy. Hum Mol Genet. 2011 Apr 15; 20(R1):R61-8. PMID: 21518733.
      Citations: 60     Fields:    Translation:HumansCells
    58. ElMallah MK, Prabhakaran S, Chesrown SE. Plastic bronchitis: resolution after heart transplantation. Pediatr Pulmonol. 2011 Aug; 46(8):824-5. PMID: 21465672.
      Citations: 2     Fields:    Translation:Humans
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