Antibody-Dependent Cell Cytotoxicity

"Antibody-Dependent Cell Cytotoxicity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

Descriptor ID	D000920
MeSH Number(s)	G12.287.070
Concept/Terms	Antibody-Dependent Cell Cytotoxicity Antibody-Dependent Cell Cytotoxicity Antibody Dependent Cell Cytotoxicity Cell Cytoxicity, Antibody-Dependent Antibody-Dependent Cell Cytoxicities Antibody-Dependent Cell Cytoxicity Cell Cytoxicities, Antibody-Dependent Cell Cytoxicity, Antibody Dependent Cytoxicities, Antibody-Dependent Cell Cytoxicity, Antibody-Dependent Cell ADCC Cytotoxicity, Antibody-Dependent Cell Antibody-Dependent Cell Cytotoxicities Cell Cytotoxicities, Antibody-Dependent Cell Cytotoxicity, Antibody-Dependent Cytotoxicities, Antibody-Dependent Cell Cytotoxicity, Antibody Dependent Cell

Below are MeSH descriptors whose meaning is more general than "Antibody-Dependent Cell Cytotoxicity".

Biological Sciences [G]
Immune System Phenomena [G12]
Cytotoxicity, Immunologic [G12.287]
Antibody-Dependent Cell Cytotoxicity [G12.287.070]

Below are MeSH descriptors whose meaning is related to "Antibody-Dependent Cell Cytotoxicity".

Below are MeSH descriptors whose meaning is more specific than "Antibody-Dependent Cell Cytotoxicity".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antibody-Dependent Cell Cytotoxicity" by people in this website by year, and whether "Antibody-Dependent Cell Cytotoxicity" was a major or minor topic of these publications.

Bar chart showing 18 publications over 14 distinct years, with a maximum of 2 publications in 2012 and 2016 and 2017 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
2006	0	1	1
2007	1	0	1
2008	0	1	1
2009	0	1	1
2010	0	1	1
2012	1	1	2
2014	1	0	1
2015	1	0	1
2016	0	2	2
2017	2	0	2
2018	0	1	1
2019	2	0	2
2022	0	1	1

Below are the most recent publications written about "Antibody-Dependent Cell Cytotoxicity" by people in Profiles.

Rieke GJ, van Bremen K, Bischoff J, ToVinh M, Monin MB, Schlabe S, Raabe J, Kaiser KM, Finnemann C, Odainic A, Kudaliyanage A, Latz E, Strassburg CP, Boesecke C, Schmidt SV, Kr?mer B, Rockstroh JK, Nattermann J. Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination. J Infect Dis. 2022 05 16; 225(10):1688-1693.

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Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019; 180(2):91-102.

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Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Pr?vost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5.

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van de Donk NWCJ, Usmani SZ. CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance. Front Immunol. 2018; 9:2134.

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Verma MK, Clemens J, Burzenski L, Sampson SB, Brehm MA, Greiner DL, Shultz LD. A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods. 2017 07; 446:47-53.

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Jegaskanda S, Co MDT, Cruz J, Subbarao K, Ennis FA, Terajima M. Induction of H7N9-Cross-Reactive Antibody-Dependent Cellular Cytotoxicity Antibodies by Human Seasonal Influenza A Viruses that are Directed Toward the Nucleoprotein. J Infect Dis. 2017 03 01; 215(5):818-823.

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Costa MR, Pollara J, Edwards RW, Seaman MS, Gorny MK, Montefiori DC, Liao HX, Ferrari G, Lu S, Wang S. Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001. J Virol. 2016 Nov 15; 90(22):10362-10378.

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Yu X, Duval M, Gawron M, Posner MR, Cavacini LA. Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition. J Immunol Res. 2016; 2016:9425172.

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Terajima M, Co MD, Cruz J, Ennis FA. High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children. J Infect Dis. 2015 Oct 01; 212(7):1052-60.

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Co MD, Terajima M, Thomas SJ, Jarman RG, Rungrojcharoenkit K, Fernandez S, Yoon IK, Buddhari D, Cruz J, Ennis FA. Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children. Viral Immunol. 2014 Oct; 27(8):375-82.

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