 Polypharmacy
"Polypharmacy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)
| Descriptor ID |
D019338
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| MeSH Number(s) |
E02.319.698
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polypharmacy".
Below are MeSH descriptors whose meaning is more specific than "Polypharmacy".
This graph shows the total number of publications written about "Polypharmacy" by people in this website by year, and whether "Polypharmacy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 2 | 3 | | 2010 | 0 | 2 | 2 | | 2012 | 3 | 0 | 3 | | 2014 | 2 | 1 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polypharmacy" by people in Profiles.
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Wenger NK, Doherty CL, Gurwitz JH, Hirsch GA, Holmes HM, Maurer MS, Murray MD. Optimization of Drug Prescription and Medication Management in Older Adults with Cardiovascular Disease. Drugs Aging. 2017 11; 34(11):803-810.
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Stock EM, Copeland LA, Tsan JY, Zeber JE, Veronin MA, Thompson AW. Association of Hospitalization With First-Line Antidepressant Polypharmacy Among Veterans of Iraq and Afghanistan With Post-Traumatic Stress Disorder: Examining the Influence of Methodological Approaches. Mil Med. 2016 10; 181(10):1248-1257.
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Latimer EA, Naidu A, Moodie EE, Clark RE, Malla AK, Tamblyn R, Wynant W. Variation in long-term antipsychotic polypharmacy and high-dose prescribing across physicians and hospitals. Psychiatr Serv. 2014 Oct; 65(10):1210-7.
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Sun F, Stock EM, Copeland LA, Zeber JE, Ahmedani BK, Morissette SB. Polypharmacy with antipsychotic drugs in patients with schizophrenia: trends in multiple health care systems. Am J Health Syst Pharm. 2014 May 01; 71(9):728-38.
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Rao SR, Reisman JI, Kressin NR, Berlowitz DR, Ash AS, Ozonoff A, Miller DR, Hylek EM, Zhao S, Rose AJ. Explaining racial disparities in anticoagulation control: results from a study of patients at the Veterans Administration. Am J Med Qual. 2015 May; 30(3):214-22.
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Clyne B, Bradley MC, Hughes C, Fahey T, Lapane KL. Electronic prescribing and other forms of technology to reduce inappropriate medication use and polypharmacy in older people: a review of current evidence. Clin Geriatr Med. 2012 May; 28(2):301-22.
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Gurwitz JH. The physics of geriatric pharmacotherapy: overcoming therapeutic inertia and momentum. Am J Med. 2012 Jun; 125(6):523-4.
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Tjia J, Givens J. Ethical framework for medication discontinuation in nursing home residents with limited life expectancy. Clin Geriatr Med. 2012 May; 28(2):255-72.
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Parsons C, Hughes CM, Passmore AP, Lapane KL. Withholding, discontinuing and withdrawing medications in dementia patients at the end of life: a neglected problem in the disadvantaged dying? Drugs Aging. 2010 Jun 1; 27(6):435-49.
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Tjia J, Rothman MR, Kiely DK, Shaffer ML, Holmes HM, Sachs GA, Mitchell SL. Daily medication use in nursing home residents with advanced dementia. J Am Geriatr Soc. 2010 May; 58(5):880-8.
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