"Thymidylate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Descriptor ID |
D013940
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MeSH Number(s) |
D08.811.913.555.500.862
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Concept/Terms |
Thymidylate Synthase- Thymidylate Synthase
- Synthase, Thymidylate
- Thymidylate Synthetase
- Synthetase, Thymidylate
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Below are MeSH descriptors whose meaning is more general than "Thymidylate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Thymidylate Synthase".
This graph shows the total number of publications written about "Thymidylate Synthase" by people in this website by year, and whether "Thymidylate Synthase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 1 | 2 |
2007 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymidylate Synthase" by people in Profiles.
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Wernimont SM, Clark AG, Stover PJ, Wells MT, Litonjua AA, Weiss ST, Gaziano JM, Vokonas PS, Tucker KL, Cassano PA. Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. J Nutr. 2012 Jul; 142(7):1272-9.
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Kairys V, Gilson MK, Lather V, Schiffer CA, Fernandes MX. Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis. Chem Biol Drug Des. 2009 Sep; 74(3):234-45.
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Yang ZF, Mott S, Rosmarin AG. The Ets transcription factor GABP is required for cell-cycle progression. Nat Cell Biol. 2007 Mar; 9(3):339-46.
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Schiffer CA, Clifton IJ, Davisson VJ, Santi DV, Stroud RM. Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry. 1995 Dec 19; 34(50):16279-87.
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DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol. 1995 Aug; 15(8):4215-24.
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Greene PJ, Yu PL, Zhao J, Schiffer CA, Santi D. Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis. Protein Sci. 1994 Jul; 3(7):1114-6.
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Schiffer CA, Davisson VJ, Santi DV, Stroud RM. Crystallization of human thymidylate synthase. J Mol Biol. 1991 May 20; 219(2):161-3.