"Thrombasthenia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
| Descriptor ID |
D013915
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| MeSH Number(s) |
C15.378.100.100.820 C15.378.140.810 C15.378.463.810 C16.320.099.820
|
| Concept/Terms |
Thrombasthenia- Thrombasthenia
- Thrombasthenias
- Thrombasthenia of Glanzmann and Naegeli
- Glanzmann Thrombasthenia
- Thrombasthenia, Glanzmann
Glanzmann Thrombasthenia, Type A- Glanzmann Thrombasthenia, Type A
- Platelet Fibrinogen Receptor, Deficiency of
- Platelet Glycoprotein IIb-IIIa Deficiency
- Platelet Glycoprotein IIb IIIa Deficiency
- Glycoprotein Complex IIb-IIIa, Deficiency Of
- Glycoprotein Complex IIb IIIa, Deficiency Of
- GP IIb-IIIa Complex, Deficiency Of
- GP IIb IIIa Complex, Deficiency Of
- Deficiency of GP 2b 3a Complex
- Platelet Glycoprotein 2b-3a Deficiency
- Platelet Glycoprotein 2b 3a Deficiency
|
Below are MeSH descriptors whose meaning is more general than "Thrombasthenia".
Below are MeSH descriptors whose meaning is more specific than "Thrombasthenia".
This graph shows the total number of publications written about "Thrombasthenia" by people in this website by year, and whether "Thrombasthenia" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thrombasthenia" by people in Profiles.
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Mezzano D, Harrison P, Frelinger AL, Mumford AD, Noris P, Lordkipanidz? M, Gresele P. Expert opinion on the use of platelet secretion assay for the diagnosis of inherited platelet function disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology. J Thromb Haemost. 2022 09; 20(9):2127-2135.
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Blair TA, Michelson AD, Frelinger AL. Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia. Sci Rep. 2018 07 09; 8(1):10300.
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Furman MI, Krueger LA, Linden MD, Barnard MR, Frelinger AL, Michelson AD. Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J Am Coll Cardiol. 2004 Jun 16; 43(12):2319-25.
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Nurden AT, Breillat C, Jacquelin B, Combri? R, Freedman J, Blanchette VS, Schmugge M, Rand ML. Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia. J Thromb Haemost. 2004 May; 2(5):813-9.
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Furman MI, Krueger LA, Frelinger AL, Barnard MR, Mascelli MA, Nakada MT, Michelson AD. GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood. Thromb Haemost. 2000 Sep; 84(3):492-8.
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Bajt ML, Ginsberg MH, Frelinger AL, Berndt MC, Loftus JC. A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. J Biol Chem. 1992 Feb 25; 267(6):3789-94.
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Ginsberg MH, Frelinger AL, Lam SC, Forsyth J, McMillan R, Plow EF, Shattil SJ. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990 Nov 15; 76(10):2017-23.