Leucine

"Leucine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An essential branched-chain amino acid important for hemoglobin formation.

Descriptor ID	D007930
MeSH Number(s)	D12.125.070.637 D12.125.142.441
Concept/Terms	Leucine Leucine L-Leucine Leucine, L-Isomer L-Isomer Leucine Leucine, L Isomer

Below are MeSH descriptors whose meaning is more general than "Leucine".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Branched-Chain [D12.125.070]
Leucine [D12.125.070.637]
Amino Acids, Essential [D12.125.142]
Leucine [D12.125.142.441]

Below are MeSH descriptors whose meaning is related to "Leucine".

Below are MeSH descriptors whose meaning is more specific than "Leucine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leucine" by people in this website by year, and whether "Leucine" was a major or minor topic of these publications.

Bar chart showing 40 publications over 20 distinct years, with a maximum of 4 publications in 2010 and 2020 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	1	0	1
2001	0	1	1
2002	1	2	3
2003	0	1	1
2004	0	1	1
2005	0	1	1
2007	0	2	2
2010	0	4	4
2011	2	0	2
2012	2	1	3
2015	1	0	1
2016	1	1	2
2017	0	1	1
2019	0	2	2
2020	2	2	4
2022	2	0	2
2023	0	4	4
2024	1	1	2
2025	0	2	2

Below are the most recent publications written about "Leucine" by people in Profiles.

Maryam A, Moquin SA, Dovala D, Kaur J, Kurt Yilmaz N, Shaqra AM, Schiffer CA. Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease. Viruses. 2025 Nov 16; 17(11).

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Zvornicanin SN, Shaqra AM, Flynn J, Carias Martinez H, Jia W, Moquin S, Dovala D, Bolon DN, Kurt Yilmaz N, Schiffer CA. Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50. mBio. 2025 May 14; 16(5):e0406824.

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Lee YU, Fox BW, Guo R, Curtis BJ, Yu J, Kim S, Nanda S, Baumann V, Yilmaz LS, Haynes CM, Schroeder FC, Walhout AJM. Host-microbe interactions rewire metabolism in a C.?elegans model of leucine breakdown deficiency. Nat Metab. 2024 Aug; 6(8):1584-1600.

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Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA. Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance. ACS Infect Dis. 2024 04 12; 10(4):1174-1184.

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Edelstein GE, Boucau J, Uddin R, Marino C, Liew MY, Barry M, Choudhary MC, Gilbert RF, Reynolds Z, Li Y, Tien D, Sagar S, Vyas TD, Kawano Y, Sparks JA, Hammond SP, Wallace Z, Vyas JM, Barczak AK, Lemieux JE, Li JZ, Siedner MJ. SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy : An Observational Study. Ann Intern Med. 2023 12; 176(12):1577-1585.

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Faust JS, Kumar A, Shah J, Khadke S, Dani SS, Ganatra S, Sax PE. Oral Nirmatrelvir and Ritonavir for Coronavirus Disease 2019 in Vaccinated, Nonhospitalized Adults Aged 18-50 Years. Clin Infect Dis. 2023 11 11; 77(9):1257-1264.

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Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA. Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS Infect Dis. 2023 07 14; 9(7):1372-1386.

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Boucau J, Uddin R, Marino C, Regan J, Flynn JP, Choudhary MC, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Turbett SE, Li JZ, Lemieux JE, Barczak AK, Siedner MJ. Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2023 02 08; 76(3):e526-e529.

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Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science. 2022 07; 377(6601):47-56.

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Zephyr J, Nageswara Rao D, Vo SV, Henes M, Kosovrasti K, Matthew AN, Hedger AK, Timm J, Chan ET, Ali A, Kurt Yilmaz N, Schiffer CA. Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance. J Mol Biol. 2022 05 15; 434(9):167503.

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