Viral Nonstructural Proteins

"Viral Nonstructural Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Descriptor ID	D017361
MeSH Number(s)	D12.776.964.900
Concept/Terms	Viral Nonstructural Proteins Viral Nonstructural Proteins Proteins, Viral Nonstructural NS Proteins, Viral Proteins, Viral NS Viral Nonstructural Protein Nonstructural Protein, Viral Protein, Viral Nonstructural Viral NS Proteins Nonstructural Proteins, Viral Viral Non-Structural Proteins Non-Structural Proteins, Viral Proteins, Viral Non-Structural Viral Non Structural Proteins Viral Nonstructural Proteins NS2 Viral Nonstructural Proteins NS2 Viral Nonstructural Proteins NS1 Viral Nonstructural Proteins NS1

Below are MeSH descriptors whose meaning is more general than "Viral Nonstructural Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Viral Nonstructural Proteins [D12.776.964.900]

Below are MeSH descriptors whose meaning is related to "Viral Nonstructural Proteins".

Below are MeSH descriptors whose meaning is more specific than "Viral Nonstructural Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Viral Nonstructural Proteins" by people in this website by year, and whether "Viral Nonstructural Proteins" was a major or minor topic of these publications.

Bar chart showing 53 publications over 23 distinct years, with a maximum of 4 publications in 2002 and 2014 and 2017 and 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	3	0	3
2002	4	0	4
2003	1	0	1
2004	1	0	1
2005	1	1	2
2006	1	1	2
2007	1	1	2
2009	1	2	3
2010	1	0	1
2011	1	1	2
2012	2	0	2
2013	3	0	3
2014	3	1	4
2015	1	0	1
2016	3	0	3
2017	3	1	4
2018	3	0	3
2019	1	0	1
2020	3	1	4
2021	0	1	1
2022	0	4	4
2024	0	1	1

Below are the most recent publications written about "Viral Nonstructural Proteins" by people in Profiles.

Cruz KG, Hill Eron M, Makhaik S, Savinov S, Hardy JA. A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease. ACS Infect Dis. 2024 02 09; 10(2):412-425.

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Zephyr J, Rao DN, Johnson C, Shaqra AM, Nalivaika EA, Jordan A, Kurt Yilmaz N, Ali A, Schiffer CA. Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease. Bioorg Chem. 2023 02; 131:106269.

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Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 11 23; 144(46):21035-21045.

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Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA. Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun. 2022 06 21; 13(1):3556.

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Flynn JM, Samant N, Schneider-Nachum G, Barkan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA. Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms. Elife. 2022 06 20; 11.

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Nageswara Rao D, Zephyr J, Henes M, Chan ET, Matthew AN, Hedger AK, Conway HL, Saeed M, Newton A, Petropoulos CJ, Huang W, Kurt Yilmaz N, Schiffer CA, Ali A. Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants. J Med Chem. 2021 08 26; 64(16):11972-11989.

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Gon?alves Pereira MH, Figueiredo MM, Queiroz CP, Magalh?es TVB, Mafra A, Diniz LMO, da Costa ?L, Gollob KJ, Antonelli LRDV, Santiago HDC. T-cells producing multiple combinations of IFN?, TNF and IL10 are associated with mild forms of dengue infection. Immunology. 2020 05; 160(1):90-102.

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Matthew AN, Zephyr J, Nageswara Rao D, Henes M, Kamran W, Kosovrasti K, Hedger AK, Lockbaum GJ, Timm J, Ali A, Kurt Yilmaz N, Schiffer CA. Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. mBio. 2020 03 31; 11(2).

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Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodr?guez R. A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. J Biol Chem. 2020 02 21; 295(8):2212-2226.

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Timm J, Kosovrasti K, Henes M, Leidner F, Hou S, Ali A, Kurt Yilmaz N, Schiffer CA. Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir. ACS Chem Biol. 2020 02 21; 15(2):342-352.

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