Adipocytes, Brown

"Adipocytes, Brown" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Fat cells with dark coloration due to the densely packed MITOCHONDRIA. They contain numerous small lipid droplets or vacuoles. Their stored lipids can be converted directly to energy as heat by the mitochondria.

Descriptor ID	D052437
MeSH Number(s)	A11.329.114.249
Concept/Terms	Adipocytes, Brown Adipocytes, Brown Adipocyte, Brown Brown Adipocyte Brown Fat Cells Brown Fat Cell Cell, Brown Fat Cells, Brown Fat Fat Cell, Brown Fat Cells, Brown Brown Adipocytes

Below are MeSH descriptors whose meaning is more general than "Adipocytes, Brown".

Anatomy [A]
Cells [A11]
Connective Tissue Cells [A11.329]
Adipocytes [A11.329.114]
Adipocytes, Brown [A11.329.114.249]

Below are MeSH descriptors whose meaning is related to "Adipocytes, Brown".

Below are MeSH descriptors whose meaning is more specific than "Adipocytes, Brown".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adipocytes, Brown" by people in this website by year, and whether "Adipocytes, Brown" was a major or minor topic of these publications.

Bar chart showing 28 publications over 14 distinct years, with a maximum of 5 publications in 2017 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2012	1	0	1
2013	1	0	1
2014	3	0	3
2015	0	1	1
2016	0	1	1
2017	4	1	5
2018	2	0	2
2019	2	1	3
2020	4	1	5
2021	1	0	1
2022	0	1	1
2023	1	1	2
2025	1	0	1

Below are the most recent publications written about "Adipocytes, Brown" by people in Profiles.

Agueda-Oyarzabal M, Isidor MS, Plucinska K, Ingerslev LR, Dmytriyeva O, Petersen PSS, Laftih S, Pontoppidan AB, Henningsen JB, Rupar K, Brown EL, Schwartz TW, Barr?s R, Gerhart-Hines Z, Sch?ele CC, Emanuelli B. Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine. Mol Metab. 2025 Mar; 93:102102.

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Haley JA, Jang C, Guertin DA. A new era of understanding in vivo metabolic flux in thermogenic adipocytes. Curr Opin Genet Dev. 2023 12; 83:102112.

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Rupar K, Isidor MS, Argemi-Muntadas L, Agueda-Oyarzabal M, Plucinska K, Brown EL, Mattanovich M, Bossi S, Tozzi M, Tandio D, Petersen PSS, Henriksen TI, Tro?t K, Hansen JB, Gerhart-Hines Z, Nielsen S, Moritz T, Emanuelli B. Full activation of thermogenesis in brown adipocytes requires Basigin action. FEBS J. 2023 05; 290(10):2673-2691.

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Chen Q, Huang L, Pan D, Hu K, Li R, Friedline RH, Kim JK, Zhu LJ, Guertin DA, Wang YX. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Nat Commun. 2022 Dec 10; 13(1):7633.

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Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nat Commun. 2021 Nov 26; 12(1):6931.

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Rabiee A, Plucinska K, Isidor MS, Brown EL, Tozzi M, Sidoli S, Petersen PSS, Agueda-Oyarzabal M, Torsetnes SB, Chehabi GN, Lundh M, Altintas A, Barr?s R, Jensen ON, Gerhart-Hines Z, Emanuelli B. White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment. Mol Metab. 2021 02; 44:101137.

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Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Sci Transl Med. 2020 08 26; 12(558).

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Entwisle SW, Martinez Calejman C, Valente AS, Lawrence RT, Hung CM, Guertin DA, Vill?n J. Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling. Mol Cell Proteomics. 2020 07; 19(7):1104-1119.

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Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Vill?n J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020 Jan 29; 11(1):575.

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Czech MP. Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab. 2020 04; 34:27-42.

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